Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Graham S Baldwin"'
Autor:
Kenny Rao, Kapil Sethi, Joseph Ischia, Luke Gibson, Laurence Galea, Lin Xiao, Mildred Yim, Mike Chang, Nathan Papa, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180028 (2017)
Ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury and chronic kidney disease. Two promising preconditioning methods for the kidney, intermittent arterial clamping (IC) and treatment with the hypoxia mimetic cobalt chloride, ha
Externí odkaz:
https://doaj.org/article/b081609772004596a4ab1ada6c7e7ce1
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140126 (2015)
The peptide hormone gastrin binds two ferric ions with high affinity, and iron binding is essential for the biological activity of non-amidated forms of the hormone. Since gastrins act as growth factors in gastrointestinal cancers, and as peptides la
Externí odkaz:
https://doaj.org/article/409573b5659149848cc5d584c233f717
Autor:
Weranja K B Ranasinghe, Lin Xiao, Suzana Kovac, Mike Chang, Carine Michiels, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54251 (2013)
BackgroundCastrate-resistant prostate cancer (CRPC) is a lethal condition in patients receiving androgen deprivation therapy for prostate cancer (PC). Despite numerous studies showing the expression of HIF1α protein under normoxia in PC cell lines,
Externí odkaz:
https://doaj.org/article/8fdcdc1151e14acaa32d31f37447b1a2
Publikováno v:
Journal of Nephropathology, Vol 9, Iss 2, Pp e12-e12 (2020)
Contrast-induced nephropathy (CIN) is an iatrogenic disease caused by the parenteral administration of iodinated contrast media (CM). A number of agents are currently being assessed to minimise or prevent CIN. Such agents are typically assessed using
Externí odkaz:
https://doaj.org/article/9a77a513f43044248702525d7a84a286
Autor:
Arthur Shulkes, Weranja Ranasinghe, David Wetherell, Graham S. Baldwin, Shomik Sengupta, Oneel Patel, Damien M Bolton, Joseph Ischia, Scott Williams
Publikováno v:
BJU International. 123:36-42
OBJECTIVES: To assess whether metformin reduces radio-resistance and increases survival in men undergoing external beam radiation therapy (EBRT) for prostate cancer (PCa), and to determine its effect on hypoxia inducible factor 1-α (HIF1α). PATIENT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4f97c30676d313deff9eb4ea6074ec
https://doi.org/10.1111/bju.14709
https://doi.org/10.1111/bju.14709
Publikováno v:
Journal of Nephrology. 32:539-547
Acute kidney injury (AKI) as a result of ischaemia-reperfusion represents a major healthcare burden worldwide. Mortality rates from AKI in hospitalized patients are extremely high and have changed little despite decades of research and medical advanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69401d5e47c50f8ecc5e20e22686263c
https://doi.org/10.1007/s40620-019-00582-6
https://doi.org/10.1007/s40620-019-00582-6
Autor:
Arthur Shulkes, Damien M Bolton, Graham S. Baldwin, Marlon Perera, Oneel Patel, Joseph Ischia
Publikováno v:
Contrast Media & Molecular Imaging, Vol 2021 (2021)
Contrast Media & Molecular Imaging
Contrast Media & Molecular Imaging
Introduction & Objectives. Contrast media (CM) causes renal injury through both direct cellular injury (cytotoxicity) and regional vascular changes (renal hypoxia) mediated by reactive oxygen species (ROS). Zinc may be able to provide protection agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a74274c64915a6f4b74e2f6848da9c
https://doaj.org/article/cdbd656f10e04c9a95b208024c4339c8
https://doaj.org/article/cdbd656f10e04c9a95b208024c4339c8
Publikováno v:
World Journal of Gastroenterology
Pancreatic cancer is one of the most aggressive and lethal malignancies worldwide, with a very poor prognosis and a five-year survival rate less than 8%. This dismal outcome is largely due to delayed diagnosis, early distant dissemination and resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04215f5e153e544cc9ee55483ff0f11a
https://doi.org/10.3748/wjg.v24.i33.3709
https://doi.org/10.3748/wjg.v24.i33.3709
Publikováno v:
Metallomics. 10:194-200
Immature forms of the peptide hormone gastrin have been implicated in the development of colorectal cancer (CRC). The biological activity of glycine-extended gastrin (Ggly) is dependent on the binding of Fe3+ ions in vitro and in vivo. The aim of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac326daf8905612094958fb6d00ee9f2
https://doi.org/10.1039/c7mt00272f
https://doi.org/10.1039/c7mt00272f
Autor:
Mal Eutick, Kathryn M. Marshall, Graham S. Baldwin, Marie Laval, Andrew M. Scott, John I. Sachinidis
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 22:999-1006
The peptide hormone gastrin (Gamide) binds trivalent metal ions, including indium (In), ruthenium (Ru) and gallium (Ga), with high affinity. Complexes of gastrin with chelated isotopes of In and Ga have previously been used for the location of tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f98b5650ee97663e98a8b67b83ce9a1
https://doi.org/10.1007/s00775-017-1478-8
https://doi.org/10.1007/s00775-017-1478-8