Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Graham Ruecroft"'
Publikováno v:
International Journal of Pharmaceutics. 430:26-33
Investigate the influence of primary crystallisation conditions on the mechanical properties and secondary processing behaviour of budesonide for dry powder inhaler (DPI) formulations. Young's modulus of two batches of budesonide crystals (samples A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedb1bc910907ac39fd05e18057a8b87
https://doi.org/10.1016/j.ijpharm.2012.03.020
https://doi.org/10.1016/j.ijpharm.2012.03.020
Publikováno v:
Journal of Pharmacy and Pharmacology. 64:1326-1336
Objectives This study aimed to investigate the relationship between the mechanical properties of anhydrous and monohydrate ipratropium bromide (IB) crystals, their processing behaviour upon air-jet micronisation and aerosolisation performance in dry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62931f79724395def5fb4579d7b875a9
https://doi.org/10.1111/j.2042-7158.2012.01522.x
https://doi.org/10.1111/j.2042-7158.2012.01522.x
Autor:
Graham Ruecroft, Sophie Bergeron, Brian S. W. Ellis, Thomas Mahoney, Jonathan R. Knight, Karen Holt-Tiffin, David A. Chaplin, and Andrew P. Osborne, Catherine Hill, John H. Edwards
Publikováno v:
Organic Process Research & Development. 10:661-665
An efficient, scaleable synthesis of ethyl (R)-4-cyano-3-hydroxybutyrate, a potential intermediate in the synthesis of Atorvastatin (Lipitor), has been developed. The three-stage process starts with reaction of low-cost epichlorohydrin with cyanide t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c0148104f1920338a10da1d9305ac69
https://doi.org/10.1021/op050257n
https://doi.org/10.1021/op050257n
Publikováno v:
Organic Process Research & Development. 9:923-932
An overview of the application of power ultrasound to crystallization of organic molecules, and the equipment developed in recent years in which sonocrystallization and sonochemistry may be carried out at industrial scale, is presented. It includes b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ff1cf53201bfaef7b1da1ca5f804399
https://doi.org/10.1021/op050109x
https://doi.org/10.1021/op050109x
Autor:
Raymond Mccague, Mark Jackson, Ian C. Lennon, Graham Ruecroft, Nicholas Parkin, Lee T. Boulton, Dean Brick, Martin E. Fox, Darren Rhodes
Publikováno v:
Organic Process Research & Development. 6:138-145
A commercial synthesis of the antiglaucoma agent, travoprost 2, is described. A total of 22 synthetic steps are required to provide the single enantiomer prostanoid, with the longest linear sequence being 16 steps from 3-hydroxybenzotrifluoride. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41b64dd498ff6c66a625f10e2c52f4c5
https://doi.org/10.1021/op010097p
https://doi.org/10.1021/op010097p
Publikováno v:
Organic Process Research & Development. 10:670-672
2‘,3‘-Dideoxy-5-fluoro-3‘-thiacytidine [(−)-FTC], the active ingredient in the antiviral drug emtricitabine (Emtriva), was prepared by a bioresolution process using cholesterol esterase immobilized on Accurel PP to resolve optical isomers of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a0cb66d5cd4d3bf343a05e3d7268f2b
https://doi.org/10.1021/op050258f
https://doi.org/10.1021/op050258f
Autor:
Graham Ruecroft, Robin Mark Bannister, and Ray McCague, Neil Henderson, Christopher H. Hanson
Publikováno v:
Organic Process Research & Development. 1:415-419
The synthesis of [3aR,4S,6R,6aS]-6-amino-N-ethyltetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide, a key single enantiomer intermediate to carbocyclic nucleosides such as adenosine agonists, is reported involving a scalable catalytic os
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f67f55f313995acf86d93746eda49630
https://doi.org/10.1021/op970026j
https://doi.org/10.1021/op970026j
Autor:
Martin Woods, Karen E. Holt, Peter D. Tiffin, Stephen Taylor, Neil Tremayne, C. Neil Morfitt, Gordon Hutton, Graham Ruecroft
Publikováno v:
Tetrahedron Letters. 38:8253-8256
An efficient “one-pot” synthesis of (R)- and (S)-2-bromo-5-phthalimidopentanoic acid from ornithine is described. Subsequent reaction with potassium thiobenzoate affords a concise, scaleable route to (R)- and (S)-enantiomers of 2-benzoylsulfanyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6d1a48a1e3a8cdc42bc9b3c88a72189
https://doi.org/10.1016/s0040-4039(97)10160-5
https://doi.org/10.1016/s0040-4039(97)10160-5
Autor:
Christel Ries, Stephen Taylor, Graham Ruecroft, Sean Savage, Raymond McCague, Christopher F. Palmer
Publikováno v:
Tetrahedron Letters. 37:4601-4604
While 4-substituted-2-cyclopentene-1-carboxylate esters gave no facial selectivity in the cis dihydroxylation of the olefin function with osmium tetroxide/N-methylmorpholine-N-oxide, the corresponding carboxamides unexpectedly gave high diastereosele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15c5581844217d364d3cb1f8e687391b
https://doi.org/10.1016/0040-4039(96)00887-8
https://doi.org/10.1016/0040-4039(96)00887-8
Publikováno v:
Pharmaceutical research. 29(4)
To investigate the influence of primary crystallization conditions on the mechanical properties and secondary processing behaviour of fluticasone propionate (FP) for carrier based dry powder inhaler (DPI) formulations.Young's modulus of FP crystals p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57944d0ece8a059618f25cc22c563702
https://pubmed.ncbi.nlm.nih.gov/22161310
https://pubmed.ncbi.nlm.nih.gov/22161310