Výsledky vyhledávání - "Graham Richmond"

Akademický článek

The Lognormal Lung: A new approach to quantifying lung inhomogeneity in COPD

Autor: Nicholas M. J. Smith, Snapper R. M. Magor-Elliott, Christopher J. Fullerton, John H. Couper, Graham Richmond, Gus Hancock, Grant A. D. Ritchie, Peter A. Robbins, Nick P. Talbot, Nayia Petousi

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Early diagnosis and disease phenotyping in COPD are currently limited by the use of spirometry, which may remain normal despite significant small-airways disease and which may not fully capture a patient’s underlying pathophysiology. In this study

Externí odkaz: https://doaj.org/article/8cbde1e426ba43139bb6d498e122ab6e

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Akademický článek

Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output

Autor: Nicholas M. J. Smith, John Couper, Graham Richmond, Dominic Sandhu, Gus Hancock, Peter A. Robbins, Grant A. D. Ritchie

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Respiratory approaches to determining cardiac output in humans are securely rooted in mass balance and therefore potentially highly accurate. To address existing limitations in the gas analysis, we developed an in-airway analyser based on la

Externí odkaz: https://doaj.org/article/a7ccd83ab1054a6e8a63eac116fd5331

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Akademický článek

Novel measure of lung function for assessing disease activity in asthma

Autor: Nayia Petousi, Nick P Talbot, Ian Pavord, Peter A Robbins, Nicholas M J Smith, John Couper, Christopher J Fullerton, Graham Richmond, Gus Hancock, Grant A D Ritchie

Publikováno v: BMJ Open Respiratory Research, Vol 7, Iss 1 (2020)

IntroductionIn asthma, lung function measures are often discordant with clinical features such as disease activity or control.MethodsWe investigated a novel technique that provides a measure (σCL) of unevenness (inhomogeneity) in lung inflation/defl

Externí odkaz: https://doaj.org/article/b32ccc74944a4ff498ea812b739c607e

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Supplementary Figure Legends from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Legends for Supplementary Figures 1 - 7.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2ea8b1988f522a97b4476bc1bfb489
https://doi.org/10.1158/0008-5472.22409537.v1

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Supplementary Figures from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Supplementary Figure 1 contains a Western blot showing the amount of estrogen receptor remaining after treatment of MCF-7 cells with AZD9496, fulvestrant and estradiol alongside GAPDH protein levels as an internal gel loading control; Supplementary F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c5919450d0037769dc8885c171e5d8
https://doi.org/10.1158/0008-5472.22409534.v1

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Data from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Fulvestrant is an estrogen receptor (ER) antagonist administered to breast cancer patients by monthly intramuscular injection. Given its present limitations of dosing and route of administration, a more flexible orally available compound has been sou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121cf8596ca6963e592f8c1559e47fd8
https://doi.org/10.1158/0008-5472.c.6507809.v1

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Supplementary Tables and Legends from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Supplementary Table 1 contains crystallographic data collection and refinements statistics for AZD9496 binding to the human estrogen receptor α ligand binding domain, Supplementary Table 2 shows the rate constants for association, dissociation and e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc4d27d54650a74388b4e3bbd209d6f
https://doi.org/10.1158/0008-5472.22409528

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Supplementary Methods from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Methods are given for: the use of SILAC assays to measure the rate of estrogen receptor α peptide degradation over time, the measurement of compound binding affinity of estrogen receptor α ligand binding domain using BIAcore, immunoblotting of estr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500fb6b45ef15b3a4c16d2efaec374bf
https://doi.org/10.1158/0008-5472.22409531

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Altered lung physiology in two cohorts after COVID-19 infection as assessed by computed cardiopulmonography

Publikováno v: Journal of applied physiology (Bethesda, Md. : 1985). 133(5)

The longer-term effects of COVID-19 on lung physiology remain poorly understood. Here, a new technique, computed cardiopulmonography (CCP), was used to study two COVID-19 cohorts (MCOVID and C-MORE-LP) at both ∼6 and ∼12 mo after infection. CCP i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ae0fc4e1cb65ba675d500061e9f35d
https://pubmed.ncbi.nlm.nih.gov/36173325

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Akademický článek

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