Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Graham Rena"'
Publikováno v:
JMIR Formative Research, Vol 8, p e53806 (2024)
BackgroundSedentary behavior (SB) is one of the largest contributing factors increasing the risk of developing noncommunicable diseases, including cardiovascular disease and type 2 diabetes. Guidelines from the World Health Organization for physical
Externí odkaz:
https://doaj.org/article/c9ca2b528bd94e759dfcc07c8f8b0401
Autor:
Calum Forteath, Ify Mordi, Raid Nisr, Erika J. Gutierrez-Lara, Noor Alqurashi, Iain R. Phair, Amy R. Cameron, Craig Beall, Ibrahim Bahr, Mohapradeep Mohan, Aaron K.F. Wong, Adel Dihoum, Anwar Mohammad, Colin N.A. Palmer, Douglas Lamont, Kei Sakamoto, Benoit Viollet, Marc Foretz, Chim C. Lang, Graham Rena
Publikováno v:
Molecular Metabolism, Vol 74, Iss , Pp 101750- (2023)
Objective: Unexplained changes in regulation of branched chain amino acids (BCAA) during diabetes therapy with metformin have been known for years. Here we have investigated mechanisms underlying this effect. Methods: We used cellular approaches, inc
Externí odkaz:
https://doaj.org/article/6034f1d72e63418cb69e689338644a8d
Autor:
Zhen Hui Peh, Adel Dihoum, Dana Hutton, J. Simon C. Arthur, Graham Rena, Faisel Khan, Chim C. Lang, Ify R. Mordi
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Heart failure with preserved ejection fraction (HFpEF) accounts for around half of all cases of heart failure and may become the dominant type of heart failure in the near future. Unlike HF with reduced ejection fraction there are few evidence-based
Externí odkaz:
https://doaj.org/article/d0e1aa5fca884514b08614539715dcd2
Autor:
Iain R. Phair, Raid B. Nisr, Andrew J.M. Howden, Magdalena Sovakova, Noor Alqurashi, Marc Foretz, Douglas Lamont, Benoit Viollet, Graham Rena
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101661- (2023)
Objective: Previous mechanistic studies on immunometabolism have focused on metabolite-based paradigms of regulation, such as itaconate. Here, we, demonstrate integration of metabolite and kinase-based immunometabolic control by AMP kinase. Methods:
Externí odkaz:
https://doaj.org/article/9997821d5e474d32b6b62c53f148b945
Publikováno v:
Digital Health, Vol 8 (2022)
Resting heart rate (RHR) is a potential cardiac disease prevention target because it is strongly associated with cardiac morbidity and mortality, yet community-based monitoring of RHR remains in its infancy. Recently, smartwatches have become availab
Externí odkaz:
https://doaj.org/article/a757be4f376d46a086a19fd8e6496a2f
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Heart failure is an important manifestation of diabetic heart disease. Before the development of symptomatic heart failure, as much as 50% of patients with type 2 diabetes mellitus (T2DM) develop asymptomatic left ventricular dysfunction including le
Externí odkaz:
https://doaj.org/article/a27c22d4aad24ce7a5117ad9e2a5fd11
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/616b15614c91426a9dea16283b4d8e1f
Autor:
Amy R. Cameron, Lisa Logie, Kashyap Patel, Stefan Erhardt, Sandra Bacon, Paul Middleton, Jean Harthill, Calum Forteath, Josh T. Coats, Calum Kerr, Heather Curry, Derek Stewart, Kei Sakamoto, Peter RepiÅ¡Äák, Martin J. Paterson, Ilmo Hassinen, Gordon McDougall, Graham Rena
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 187-197 (2018)
Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that
Externí odkaz:
https://doaj.org/article/4594871bfca64daf88a105477355aaec
Publikováno v:
Expert Opinion on Investigational Drugs. 32:291-299
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18459ce3e664e69c397db140c085641b
https://doi.org/10.1080/13543784.2023.2196010
https://doi.org/10.1080/13543784.2023.2196010
Autor:
Iain R. Phair, Raid B. Nisr, Andrew J.M. Howden, Magdalena Sovakova, Noor Alqurashi, Marc Foretz, Douglas Lamont, Benoit Viollet, Graham Rena
Publikováno v:
Molecular metabolism.
Previous mechanistic studies on immunometabolism have focused on metabolite-based paradigms of regulation, such as itaconate. Here, we combine whole cell quantitative proteomics with gene knockout of AMPKα1, to demonstrate integration of metabolite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e114a64b5c050a0c0494128f41d34faa
https://pubmed.ncbi.nlm.nih.gov/36586434
https://pubmed.ncbi.nlm.nih.gov/36586434