Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Graham R. Standen"'
Autor:
Adrian Charles, Gillian F.J. White, Anthony R. Dallosso, Jessica Charlet, Karim Malik, Keith W. Brown, Graham R. Standen
Publikováno v:
Cancer Genetics. 205:319-326
Despite considerable advances in understanding the molecular pathogenesis of Wilms' tumor (WT), its cell biology is less well understood, partly due to the paucity of established WT cell lines. We report here the establishment of a new anaplastic WT
Autor:
Lorna W. Harries, Katy Hanlon, Elizabeth C. Wolstencroft, Alexander Sternberg, Sian Ellard, Graham R. Standen
Publikováno v:
The Journal of Molecular Diagnostics. 9:42-46
Achieving a specific diagnosis of polycythemia vera (PV) and other myeloproliferative disorders (MPDs) is often costly and complex. However, the recent identification of a V617F mutation in the JH2 domain of the JAK2 gene in a high proportion of pati
Autor:
Riaz Janmohammed, Paresh Vyas, Richard Kaczmarski, Shamit Soneji, Sally Killick, Thomas Seidl, Andrew Carr, Tim Littlewood, Joanne Leach, Claire Chapman, Alexander Sternberg, Andy Peniket, K Clipsham, Edwin Massey, Chris Hatton, Graham R. Standen, Bipin Vadher, Lisa J. Robinson, David G. Bowen
Publikováno v:
Blood. 106:2982-2991
Early, low-risk International Prognostic Scoring System (IPSS) myelodysplastic syndrome (MDS) is a heterogeneous disorder where the molecular and cellular hematopoietic defects are poorly understood. To gain insight into this condition, we analyzed g
Publikováno v:
Human Mutation. 24:93-99
Thiopurine-based drugs are a widely prescribed group of medications. Their tolerance and effectiveness is dependent on an individual’s ability to metabolize these compounds. An essential enzyme for the metabolism of these drugs is thiopurine S-meth
Publikováno v:
European Journal of Gastroenterology & Hepatology. 11:1289-1292
BACKGROUND: A thrombotic aetiology for inflammatory bowel disease (IBD) has been proposed as a result of its association with thrombo-embolic complications, smoking, the oral contraceptive pill and the response of ulcerative colitis (UC) patients to
Autor:
Timothy Clench, Graham R. Standen
Publikováno v:
British Journal of Haematology. 140:714-716
Autor:
Claudine Mazurier, A. M. Cumming, Jeffrey L. Bidwell, S. Keeney, Graham R. Standen, Derrick John Bowen, Christine Gaucher
Publikováno v:
Thrombosis and Haemostasis. 80:32-36
SummaryThe majority of patients with type 2N von Willebrand disease (VWD type 2N) have mutations in the region of the von Willebrand factor (VWF) gene encoding the factor VIII binding domain of VWF. Two mutations predominate among VWD type 2N patient
Publikováno v:
Blood. 90:2701-2715
We have shown previously that the Rhesus (Rh) polypeptides are the commonest targets for pathogenic anti-red blood cell (RBC) autoantibodies in patients with autoimmune hemolytic anemia (AIHA). The aim of the current work was to determine whether act
Publikováno v:
British Journal of Haematology. 98:346-352
Molecular analysis has been performed on a Malaysian patient with a severe bleeding disorder due to factor XIII(A) subunit deficiency. Total mRNA was isolated from the patient's leucocytes and four overlapping segments corresponding to the entire cod
Autor:
Jeffrey L. Bidwell, S. Granville, Nigel Wood, S. Bowley, Derrick John Bowen, Graham R. Standen
Publikováno v:
Thrombosis and Haemostasis. 77:119-122
SummaryA new genetic test has been developed for detection of the mutation known as factor V Leiden. The test employs heteroduplex technology and comprises a single PCR reaction followed immediately by PCR product analysis. It therefore represents th