Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Graham R. Bignell"'
Autor:
Michael P. Menden, Francesco Paolo Casale, Johannes Stephan, Graham R. Bignell, Francesco Iorio, Ultan McDermott, Mathew J. Garnett, Julio Saez-Rodriguez, Oliver Stegle
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Little is known about the contribution of germline genetic variants to cancer drug sensitivity. Here, the authors devise an approach for joint analysis of germline variants and somatic mutations, identifying substantial germline contributions to vari
Externí odkaz:
https://doaj.org/article/a5f22af9ae8a4bdfa6b0d4bf920d0315
Autor:
Jiqiu Cheng, Jonas Demeulemeester, David C. Wedge, Hans Kristian M. Vollan, Jason J. Pitt, Hege G. Russnes, Bina P. Pandey, Gro Nilsen, Silje Nord, Graham R. Bignell, Kevin P. White, Anne-Lise Børresen-Dale, Peter J. Campbell, Vessela N. Kristensen, Michael R. Stratton, Ole Christian Lingjærde, Yves Moreau, Peter Van Loo
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Homozygous deletions are rare in cancers and often target tumour suppressor genes. Here, the authors conduct pan-cancer analyses and apply statistical modelling to identify 27 candidate tumour suppressors, including MAFTRR, KIAA1551, and IGF2BP2.
Externí odkaz:
https://doaj.org/article/e28c2813abff4f109325d96bafff3976
Autor:
Jiqiu Cheng, Jonas Demeulemeester, David C. Wedge, Hans Kristian M. Vollan, Jason J. Pitt, Hege G. Russnes, Bina P. Pandey, Gro Nilsen, Silje Nord, Graham R. Bignell, Kevin P. White, Anne-Lise Børresen-Dale, Peter J. Campbell, Vessela N. Kristensen, Michael R. Stratton, Ole Christian Lingjærde, Yves Moreau, Peter Van Loo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The original version of this Article omitted a declaration from the competing interests statement, which should have included the following: ‘K.P.W. is President of Tempus Lab, Inc., Chicago, IL, USA’. This has now been corrected in both the PDF
Externí odkaz:
https://doaj.org/article/8456cf857ba94524809cf64333ad72c5
Autor:
Jiqiu Cheng, Jonas Demeulemeester, David C. Wedge, Hans Kristian M. Vollan, Jason J. Pitt, Hege G. Russnes, Bina P. Pandey, Gro Nilsen, Silje Nord, Graham R. Bignell, Kevin P. White, Anne-Lise Børresen-Dale, Peter J. Campbell, Vessela N. Kristensen, Michael R. Stratton, Ole Christian Lingjærde, Yves Moreau, Peter Van Loo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The original version of this Article contained an error in the author affiliations. The affiliation of Kevin P. White with Tempus Labs, Inc., Chicago, IL, USA was inadvertently omitted.This has now been corrected in both the PDF and HTML versions of
Externí odkaz:
https://doaj.org/article/340c2accd0cc41b6a16ec2081ec57688
Autor:
David J. Adams, Tim Hubbard, Lara S. Collier, Anton Berns, Maarten van Lohuizen, P. Andy Futreal, Michael R. Stratton, David A. Largaespada, Louise van der Weyden, Catherine H. Wilson, Markus Brosch, Alistair G. Rust, Adam Butler, Graham R. Bignell, Jos Jonkers, Lodewyk Wessels, Jeroen de Ridder, Anthony G. Uren, Jaap Kool, Jenny Mattison
Supplementary Table 6 from Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2289d578fc1d7b63139101d1d03793e
https://doi.org/10.1158/0008-5472.22386599
https://doi.org/10.1158/0008-5472.22386599
Autor:
David J. Adams, Tim Hubbard, Lara S. Collier, Anton Berns, Maarten van Lohuizen, P. Andy Futreal, Michael R. Stratton, David A. Largaespada, Louise van der Weyden, Catherine H. Wilson, Markus Brosch, Alistair G. Rust, Adam Butler, Graham R. Bignell, Jos Jonkers, Lodewyk Wessels, Jeroen de Ridder, Anthony G. Uren, Jaap Kool, Jenny Mattison
Comparative genomic hybridization (CGH) can reveal important disease genes but the large regions identified could sometimes contain hundreds of genes. Here we combine high-resolution CGH analysis of 598 human cancer cell lines with insertion sites is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559c580e0196c98d38f7d71fd3dbe244
https://doi.org/10.1158/0008-5472.c.6501584.v1
https://doi.org/10.1158/0008-5472.c.6501584.v1
Autor:
David J. Adams, Tim Hubbard, Lara S. Collier, Anton Berns, Maarten van Lohuizen, P. Andy Futreal, Michael R. Stratton, David A. Largaespada, Louise van der Weyden, Catherine H. Wilson, Markus Brosch, Alistair G. Rust, Adam Butler, Graham R. Bignell, Jos Jonkers, Lodewyk Wessels, Jeroen de Ridder, Anthony G. Uren, Jaap Kool, Jenny Mattison
Supplementary Methods from Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5116204936401f059ff3c5ad97d43255
https://doi.org/10.1158/0008-5472.22386602
https://doi.org/10.1158/0008-5472.22386602
Autor:
David J. Adams, Tim Hubbard, Lara S. Collier, Anton Berns, Maarten van Lohuizen, P. Andy Futreal, Michael R. Stratton, David A. Largaespada, Louise van der Weyden, Catherine H. Wilson, Markus Brosch, Alistair G. Rust, Adam Butler, Graham R. Bignell, Jos Jonkers, Lodewyk Wessels, Jeroen de Ridder, Anthony G. Uren, Jaap Kool, Jenny Mattison
Supplementary Tables 1-5 from Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68821b146c652a6305f71cf1619161f8
https://doi.org/10.1158/0008-5472.22386593
https://doi.org/10.1158/0008-5472.22386593
Autor:
David J. Adams, Tim Hubbard, Lara S. Collier, Anton Berns, Maarten van Lohuizen, P. Andy Futreal, Michael R. Stratton, David A. Largaespada, Louise van der Weyden, Catherine H. Wilson, Markus Brosch, Alistair G. Rust, Adam Butler, Graham R. Bignell, Jos Jonkers, Lodewyk Wessels, Jeroen de Ridder, Anthony G. Uren, Jaap Kool, Jenny Mattison
Supplementary Table 7 from Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12eeac7fd9c5ef28de657d84bf098aa8
https://doi.org/10.1158/0008-5472.22386596.v1
https://doi.org/10.1158/0008-5472.22386596.v1
Autor:
Julio Saez-Rodriguez, Graham R. Bignell, Euan A. Stronach, Beiyuan Fu, Angela Matchan, Fiona M. Behan, Emanuel Gonçalves, Ruby Banerjee, Elisabeth Chen, Ultan McDermott, Gabriele Picco, Fengtang Yang, Kosuke Yusa, Luz Garcia Alonso, Cyril H. Benes, David J. Dow, Adam Butler, Elizabeth Anderson, Francesco Iorio, Mathew J. Garnett
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Many gene fusions are reported in tumours and for most their role remains unknown. As fusions are used for diagnostic and prognostic purposes, and are targets for treatment, it is crucial to assess their function in cancer. To systematically investig