Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Graham R. Baker"'
Autor:
Lucy H. Elliot, Pitt Gary Robert William, Franklin Richard Jeremy, Doreen M. Ashworth, Michael Szelke, Satoshi Yamamoto, Andrew John Baxter, Graham R. Baker, D.Michael Evans, Andrew Sheppard, David W.M. Benzies, Graeme Semple, Rooker David Philip, Peter Hudson, Paul D. Jenkins, Andrzej Roman Batt, Yasuo Isomura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1337-1342
New potent, reversible inhibitors of recombinant human Interleukin-1β-converting enzyme (ICE, caspase-1) with significantly reduced peptide character are described. The compounds were designed by incorporation of pyridone and pyrimidone heterocyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51cb0170ce05f4c726aed52a2ab09800
https://doi.org/10.1016/s0960-894x(97)00220-5
https://doi.org/10.1016/s0960-894x(97)00220-5
Autor:
Paul D. Jenkins, Michael Szelke, Andrew John Baxter, Graham R. Baker, D. Michael Jones, Butrus Atrash, Doreen M. Ashworth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2745-2748
A series of stable, very potent inhibitors of dipeptidyl peptidase IV has been developed. A number of dipeptide analogues, incorporating a 4-cyanothiazolidide, were found to have Ki values of less than 1 nM versus human DP-IV and half-lives of betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17f8b016318652f4cc2a98b0da1c7c60
https://doi.org/10.1016/s0960-894x(96)00491-x
https://doi.org/10.1016/s0960-894x(96)00491-x
Autor:
Butrus Atrash, Paul D. Jenkins, Andrew John Baxter, Doreen M. Ashworth, D. Michael Jones, Michael Szelke, Graham R. Baker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1163-1166
A novel series of stable, potent inhibitors of dipeptidyl peptidase IV has been developed. A number of dipeptide analogues, incorporating a 2-cyanopyrrolidide, were found to have K i values of less than 5 nM versus human DP-IV and half-lives of >48h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5e56b6b3093ea7971ae18fe19263c17
https://doi.org/10.1016/0960-894x(96)00190-4
https://doi.org/10.1016/0960-894x(96)00190-4
Publikováno v:
ChemInform. 23
D- and L- myo -inositol 1-phosphorothioate have been synthesized from 2,3,4,5,6- O -pentabenzyl- myo -inositol. Both enantiomers are slow substrates for inositol monophosphatase and weak competitive inhibitors, therefore, ideal probes for the phospha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e5c306d9db45c92f92cad16a9059333
https://doi.org/10.1002/chin.199238248
https://doi.org/10.1002/chin.199238248
Autor:
D. M. Jones, Doreen M. Ashworth, Paul D. Jenkins, Andrew John Baxter, Michael Szelke, Graham R. Baker, Butrus Atrash
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6bf8740f104976c0b186ceb449138a9
https://doi.org/10.1002/chin.199637263
https://doi.org/10.1002/chin.199637263
Autor:
Andrew John Baxter, Butrus Atrash, Doreen M. Ashworth, Paul D. Jenkins, Michael Szelke, Graham R. Baker, D. M. Jones
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c098e05ce44abd0d91c6d47f0f185c70
https://doi.org/10.1002/chin.199715136
https://doi.org/10.1002/chin.199715136
Autor:
Y. Isomura, Lucy H. Elliot, Andrew John Baxter, Peter Hudson, S. Yamamoto, Paul D. Jenkins, Andrzej Roman Batt, Doreen M. Ashworth, Graeme Semple, Andrew Sheppard, Michael Szelke, Graham R. Baker, Pitt Gary Robert William, David Michael Evans, David W.M. Benzies, Franklin Richard Jeremy, Rooker David Philip
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae4f35e5d83594bb3d778a27d6652dc
https://doi.org/10.1002/chin.199739227
https://doi.org/10.1002/chin.199739227
Autor:
Graham R. Baker, David Gani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:193-196
Inositol monophosphatase is unable to catalyse the exchange of 18O-label from 18O-water into inorganic phosphate in the absence of inositol. The inositol mediated exchange reaction is Mg2+ dependent, shows a similar pH dependence to that for the hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e06cabefbf27d0a7875c1443578e8e
https://doi.org/10.1016/s0960-894x(00)80250-4
https://doi.org/10.1016/s0960-894x(00)80250-4
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:17-20
D- and L- myo -inositol 1-phosphorothioate have been synthesized from 2,3,4,5,6- O -pentabenzyl- myo -inositol. Both enantiomers are slow substrates for inositol monophosphatase and weak competitive inhibitors, therefore, ideal probes for the phospha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::567b136fdad28f6ae1165c5c57743327
https://doi.org/10.1016/s0960-894x(01)81082-9
https://doi.org/10.1016/s0960-894x(01)81082-9
Publikováno v:
European journal of biochemistry. 212(3)
Lithium-sensitive inositol monophosphatase from bovine brain was purified from brain and from a recombinant strain of Escherichia coli BL21-DE3. The natural and recombinant enzymes displayed identical physical and kinetic properties. At low [Li+], Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7a48450c41f21475ec061ebc5fc0b0
https://pubmed.ncbi.nlm.nih.gov/8385008
https://pubmed.ncbi.nlm.nih.gov/8385008