Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Graham P. Wilkin"'
Publikováno v:
Parkinsonism & Related Disorders. 8:329-341
We show the cellular distribution of immunoreactivity (IR) for brain-derived-neurotrophic-factor (BDNF), neurotrophin-3 (NT-3) and tyrosine kinase receptors TRKB and TRKC in idiopathic Parkinson's disease (IPD) and controls at post-mortem. In both gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ccd9f89c5aca016e4a8fcb1c62cfb7
https://doi.org/10.1016/s1353-8020(02)00008-1
https://doi.org/10.1016/s1353-8020(02)00008-1
Publikováno v:
Molecular and Cellular Neuroscience. 16:724-739
Degeneration of dopaminergic neurons and focal gliosis are pathological hallmarks of Parkinson's disease and although the brain is described as immune-privileged focal immune reactions surround failing nigral neurons. We examined the cellular distrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78765276ed69191520dc5c77bec49330
https://doi.org/10.1006/mcne.2000.0914
https://doi.org/10.1006/mcne.2000.0914
Autor:
Vittorio Gallo, Oleg G. Shamotienko, Patrick G. Foran, Christine Knott, J. Oliver Dolly, Cristina A. Ghiani, Subathra Poopalasundaram, Graham P. Wilkin
Publikováno v:
Glia. 30:362-372
Previous electrophysiological evidence has indicated that astrocytes and oligodendrocytes express inwardly rectifying K(+) channels both in vitro and in vivo. Here, for the first time, we have undertaken light microscopic immunohistochemical studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9853f69829a6ca6e9e3ef97e8c8372ca
https://doi.org/10.1002/(sici)1098-1136(200006)30:4<362::aid-glia50>3.0.co
https://doi.org/10.1002/(sici)1098-1136(200006)30:4<362::aid-glia50>3.0.co
Publikováno v:
Parkinsonism & Related Disorders. 5:115-122
There is evidence that astrocytes and microglia can release agents which might have a protective effect on damaged neurons. However the associations of glia with dopaminergic neurons in Parkinson's disease are not defined. Our studies showed that in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63496abcd103a489862690416551913
https://doi.org/10.1016/s1353-8020(99)00022-x
https://doi.org/10.1016/s1353-8020(99)00022-x
Publikováno v:
Glia. 26:333-343
An understanding of the role of reactive glia in the neurodegenerative/regenerative process requires a knowledge of the molecules synthesised by these cells following trauma. We investigated the cellular localisation of lipocortin-1 (LC-1), a putativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac905c3cd0ac3dc7110688924712c11e
https://doi.org/10.1002/(sici)1098-1136(199906)26:4<333::aid-glia7>3.0.co
https://doi.org/10.1002/(sici)1098-1136(199906)26:4<333::aid-glia7>3.0.co
Publikováno v:
Brain Research. 816:29-37
Astrocytes are potentially useful as vehicles for gene transfer into the CNS. As endogenous CNS cells, they possess secretory mechanisms and can be grown in vitro. We have developed an animal model of this system using autologous astrocyte grafts in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18d84f5a79392ca5bd08b0fadf7cdf0
https://doi.org/10.1016/s0006-8993(98)01061-0
https://doi.org/10.1016/s0006-8993(98)01061-0
Publikováno v:
Molecular Brain Research. 61:90-99
The literature describing the expression of 5-HT receptor subtypes by astrocytes is controversial and incomplete. It is clear that primary cultures of astrocytes express receptors of the 5-HT2 family coupled to phospholipase C and of the 5-HT7 recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e47cc89556238571e6d4deab9e5f3e4
https://doi.org/10.1016/s0169-328x(98)00206-x
https://doi.org/10.1016/s0169-328x(98)00206-x
Publikováno v:
Neurochemistry International. 28:283-291
The nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase histochemical technique was used as a marker to assess the distribution of nitric oxide synthase activity in the carp retina. NADPH-diaphorase activity was found to be present in phot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91fdca87bd81721638e8f01094e0c91
https://doi.org/10.1016/0197-0186(95)00090-9
https://doi.org/10.1016/0197-0186(95)00090-9
Publikováno v:
Neuroscience Letters. 167:67-72
Dual colour immunofluorescence has been used to compare the distribution of serotonin (5-hydroxytryptamine, 5-HT) and GAP-43 in the adult rat. GAP-43 immunostaining was observed in all spinal cord regions containing 5-HT immunoreactivity. 5-HT and GA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6460be82ac0102549918acd4a86fc9
https://doi.org/10.1016/0304-3940(94)91029-4
https://doi.org/10.1016/0304-3940(94)91029-4
Up-regulation of lipocortin-1 and its mRNA in reactive astrocytes in kainate-lesioned rat cerebellum
Autor:
Karen A. Young, Derek R. Marriott, Graham P. Wilkin, Lynette Mullens, Lesley A. Tannahill, Stafford L. Lightman
Publikováno v:
Journal of Neuroimmunology. 50:25-33
We have used a combined molecular and immunocytochemical approach to examine the expression of lipocortin-1 (LC-1) in kainate-lesioned rat cerebellum. Using immunocytochemistry, Western and Northern blotting, we have shown upregulation of LC-1 mRNA a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ac291f04acab157bef99719acd1d85
https://doi.org/10.1016/0165-5728(94)90211-9
https://doi.org/10.1016/0165-5728(94)90211-9