Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Graham P, Cook"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The membrane-bound lymphocyte-specific protein-tyrosine kinase (Lck) triggers T cell antigen receptor signalling to initiate adaptive immune responses. Despite many structure–function studies, the mode of action of Lck and the potential ro
Externí odkaz:
https://doaj.org/article/d48e41c0e0ad4909887a6f3fb90ef561
Autor:
Aarren J. Mannion, Adam F. Odell, Syed Murtuza Baker, Laura C. Matthews, Pamela F. Jones, Graham P. Cook
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
CD146, also known as melanoma cell adhesion molecule (MCAM), is expressed in numerous cancers and has been implicated in the regulation of metastasis. We show that CD146 negatively regulates transendothelial migration (TEM) in breast cancer. This inh
Externí odkaz:
https://doaj.org/article/91b1642de92d457a99a0a2a29369437a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/a8ac33c904c64e34a07965b23a43f5f7
Autor:
Helen Carrasco Hope, Gabriella Pickersgill, Pierpaolo Ginefra, Nicola Vannini, Graham P. Cook, Robert J. Salmond
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
T cell activation is dependent upon the integration of antigenic, co-stimulatory and cytokine-derived signals and the availability and acquisition of nutrients from the environment. Furthermore, T cell activation is accompanied by reprogramming of ce
Externí odkaz:
https://doaj.org/article/d81420ad01cb441db801bd0ef0b2bfef
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009232 (2021)
The T cell receptor (TCR-CD3) initiates T cell activation by binding to peptides of Major Histocompatibility Complexes (pMHC). The TCR-CD3 topology is well understood but the arrangement and dynamics of its cytoplasmic tails remains unknown, limiting
Externí odkaz:
https://doaj.org/article/eef43c7c0731423c8ca702ee06b2de21
Autor:
Lynette Steele, Aarren J. Mannion, Gary Shaw, Kenneth A. Maclennan, Graham P. Cook, Christopher E. Rudd, Alison Taylor
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102555- (2021)
Summary: Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GSK-3 inhibition enhances T cell function and is effective in the control of tumor growth. GSK-3 has two co-expressed isoforms, GSK-3α and GSK
Externí odkaz:
https://doaj.org/article/3f9855539d254976a5185ff195874f3e
Autor:
Claire Scott, Jayakanth Kankanala, Toshana L Foster, Daniel H Goldhill, Peng Bao, Katie Simmons, Marieke Pingen, Matthew Bentham, Elizabeth Atkins, Eleni Loundras, Ruth Elderfield, Jolyon K Claridge, Joseph Thompson, Peter R Stilwell, Ranjitha Tathineni, Clive S McKimmie, Paul Targett-Adams, Jason R Schnell, Graham P Cook, Stephen Evans, Wendy S Barclay, Richard Foster, Stephen Griffin
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008716 (2020)
Pandemic influenza A virus (IAV) remains a significant threat to global health. Preparedness relies primarily upon a single class of neuraminidase (NA) targeted antivirals, against which resistance is steadily growing. The M2 proton channel is an alt
Externí odkaz:
https://doaj.org/article/b1c9af88e0784e2fbf40273c4f74c8fe
Autor:
Michelle Wantoch, Erica B. Wilson, Alastair P. Droop, Sarah L. Phillips, Matt Coffey, Yasser M. El‐Sherbiny, Tim D. Holmes, Alan A. Melcher, Laura F. Wetherill, Graham P. Cook
Publikováno v:
Immunology. 166:104-120
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab76b64824716ce570203c30c796cdf7
https://doi.org/10.1111/imm.13453
https://doi.org/10.1111/imm.13453
Autor:
Julia Newton-Bishop, D. Timothy Bishop, Graham P. Cook, Mitchell P. Levesque, Sandra Nicole Freiberger, Sabrina A. Hogan, Sathya Muralidhar, Juliette A. Randerson-Moor, Tracey Mell, John R. Davies, Mark Harland, Anastasia Filia, Alastair P. Droop, Joey Mark S. Diaz, Sally J. O’Shea, Jonathan P. Laye, Jérémie Nsengimana, Joanna Poźniak
The immune response to melanoma improves the survival in untreated patients and predicts the response to immune checkpoint blockade. Here, we report genetic and environmental predictors of the immune response in a large primary cutaneous melanoma coh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1806e41b3116939a2773cdc2d6761d28
https://doi.org/10.1158/0008-5472.c.6510066.v1
https://doi.org/10.1158/0008-5472.c.6510066.v1
Autor:
Julia Newton-Bishop, D. Timothy Bishop, Graham P. Cook, Mitchell P. Levesque, Sandra Nicole Freiberger, Sabrina A. Hogan, Sathya Muralidhar, Juliette A. Randerson-Moor, Tracey Mell, John R. Davies, Mark Harland, Anastasia Filia, Alastair P. Droop, Joey Mark S. Diaz, Sally J. O’Shea, Jonathan P. Laye, Jérémie Nsengimana, Joanna Poźniak
Gene lists per immune cell type after successive filtration steps.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317f1910dfc59cb6b9a7bdf9b593a4a2
https://doi.org/10.1158/0008-5472.22418220
https://doi.org/10.1158/0008-5472.22418220