Výsledky vyhledávání - "Graham P, Cook"

Akademický článek

Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase (Lck)

Autor: Dheeraj Prakaash, Charline Fagnen, Graham P. Cook, Oreste Acuto, Antreas C. Kalli

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract The membrane-bound lymphocyte-specific protein-tyrosine kinase (Lck) triggers T cell antigen receptor signalling to initiate adaptive immune responses. Despite many structure–function studies, the mode of action of Lck and the potential ro

Externí odkaz: https://doaj.org/article/d48e41c0e0ad4909887a6f3fb90ef561

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Akademický článek

Pro- and anti-tumour activities of CD146/MCAM in breast cancer result from its heterogeneous expression and association with epithelial to mesenchymal transition

Autor: Aarren J. Mannion, Adam F. Odell, Syed Murtuza Baker, Laura C. Matthews, Pamela F. Jones, Graham P. Cook

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

CD146, also known as melanoma cell adhesion molecule (MCAM), is expressed in numerous cancers and has been implicated in the regulation of metastasis. We show that CD146 negatively regulates transendothelial migration (TEM) in breast cancer. This inh

Externí odkaz: https://doaj.org/article/91b1642de92d457a99a0a2a29369437a

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Akademický článek

Editorial: Factors determining long term anti-tumor responses to immune checkpoint blockade therapy

Autor: Roberta Zappasodi, Graham P. Cook, Alison Taylor

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Externí odkaz: https://doaj.org/article/a8ac33c904c64e34a07965b23a43f5f7

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Akademický článek

TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells

Autor: Helen Carrasco Hope, Gabriella Pickersgill, Pierpaolo Ginefra, Nicola Vannini, Graham P. Cook, Robert J. Salmond

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

T cell activation is dependent upon the integration of antigenic, co-stimulatory and cytokine-derived signals and the availability and acquisition of nutrients from the environment. Furthermore, T cell activation is accompanied by reprogramming of ce

Externí odkaz: https://doaj.org/article/d81420ad01cb441db801bd0ef0b2bfef

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Akademický článek

Multi-scale simulations of the T cell receptor reveal its lipid interactions, dynamics and the arrangement of its cytoplasmic region.

Autor: Dheeraj Prakaash, Graham P Cook, Oreste Acuto, Antreas C Kalli

Publikováno v: PLoS Computational Biology, Vol 17, Iss 7, p e1009232 (2021)

The T cell receptor (TCR-CD3) initiates T cell activation by binding to peptides of Major Histocompatibility Complexes (pMHC). The TCR-CD3 topology is well understood but the arrangement and dynamics of its cytoplasmic tails remains unknown, limiting

Externí odkaz: https://doaj.org/article/eef43c7c0731423c8ca702ee06b2de21

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Akademický článek

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection

Autor: Lynette Steele, Aarren J. Mannion, Gary Shaw, Kenneth A. Maclennan, Graham P. Cook, Christopher E. Rudd, Alison Taylor

Publikováno v: iScience, Vol 24, Iss 6, Pp 102555- (2021)

Summary: Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GSK-3 inhibition enhances T cell function and is effective in the control of tumor growth. GSK-3 has two co-expressed isoforms, GSK-3α and GSK

Externí odkaz: https://doaj.org/article/3f9855539d254976a5185ff195874f3e

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