Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Graham Molineux"'
Autor:
Patricia McElroy, Keri Buck, Graham Molineux, Ping Wei, Angus M. Sinclair, Barbra Sasu, Michael Eschenberg
Publikováno v:
Experimental Hematology. 43(6):479-487
Chemotherapy-induced thrombocytopenia can lead to chemotherapy treatment delays or dose reductions. The ability of romiplostim, a thrombopoietin (TPO) mimetic, to promote platelet recovery in a mouse model of multicycle chemotherapy/radiation therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81ff8c5d79e62064d72866d80fa438a
Autor:
Ping Wei, Graham Molineux
Publikováno v:
Peptide Drug Discovery and Development: Translational Research in Academia and Industry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ca799dffc412e0ff646d11176a34752
https://doi.org/10.1002/9783527636730.ch9
https://doi.org/10.1002/9783527636730.ch9
Autor:
Graham Molineux
Publikováno v:
Annals of the New York Academy of Sciences. 1222:55-63
Comprised of peptide and carrier components in an overall structure superficially resembling an antibody, romiplostim is the prototype of a new class of protein therapeutics called peptibodies. Romiplostim (AMG 531, Nplate) was designed to evade the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23c6d83bc97149bcf80e1092c3a7c3c1
https://doi.org/10.1111/j.1749-6632.2011.05975.x
https://doi.org/10.1111/j.1749-6632.2011.05975.x
Autor:
Keegan Cooke, Todd Juan, C. Glenn Begley, Cherylene Plewa, Hongyan Li, Aaron R. Ellison, Tara Arvedson, Graham Molineux, Aaron George Winters, Barbra Sasu, Jackie Sheng
Publikováno v:
Blood. 115:3616-3624
Iron maldistribution has been implicated in multiple diseases, including the anemia of inflammation (AI), atherosclerosis, diabetes, and neurodegenerative disorders. Iron metabolism is controlled by hepcidin, a 25-amino acid peptide. Hepcidin is indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d9e42981d20cc2ab28d810d25906ad
https://doi.org/10.1182/blood-2009-09-245977
https://doi.org/10.1182/blood-2009-09-245977
Autor:
Linda O. Narhi, Graham Molineux, Sameer Doshi, Balaji Agoram, Ken Aoki, Steve Elliott, Colin V. Gegg, Graham Richard Jang
Publikováno v:
Journal of Pharmaceutical Sciences. 98:2198-2211
Erythropoietin (EPO) receptor-mediated endocytosis and degradation in the bone marrow has been hypothesized to be the major clearance pathway of erythropoiesis-stimulating agents (ESA). We investigated the role of this pathway in ESA clearance by det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc79524cfce27766fb893c5f96987b8
https://doi.org/10.1002/jps.21578
https://doi.org/10.1002/jps.21578
Autor:
Evert-Jan F. M. de Kruijf, Graham Molineux, Henny Hagoort, Melissa van Pel, Roel Willemze, Donnée Kruysdijk, Willem E. Fibbe
Publikováno v:
Human Immunology. 68:368-374
Administration of recombinant-human G-CSF (rhG-CSF) is highly efficient in mobilizing hematopoietic stem and progenitor cells (HSC/HPC) from the bone marrow (BM) toward the peripheral blood. This study was designed to investigate whether repeated G-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccd4b72114a39fb560cdfb869277902
https://doi.org/10.1016/j.humimm.2007.01.017
https://doi.org/10.1016/j.humimm.2007.01.017
Autor:
Patricia McElroy, Jeffrey K. Browne, C. Glenn Begley, Barbra Sasu, Cynthia Hartley, Raheemuddin Khaja, Henry Schultz, Joan C. Egrie, Steven G. Elliott, Graham Molineux
Publikováno v:
Acta Haematologica. 113:163-174
The unit of erythropoietic activity has long been the standard by which erythropoietic agents are judged, but the development of long-acting agents such as darbepoetin alfa has highlighted the shortcomings of this approach. To this point, we compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afce8ed906d8e22da42364f184e7d26
https://doi.org/10.1159/000084446
https://doi.org/10.1159/000084446
Publikováno v:
Cancer Research. 65:284-290
Darbepoietin alfa (DA) is a long-acting analogue of erythropoietin that has reduced receptor affinity and enhanced biological activity. Experiments were done to test the hypothesis that correction of anemia in tumor-bearing mice by DA would increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e555115a46493c5109621fcd31651d
https://doi.org/10.1158/0008-5472.284.65.1
https://doi.org/10.1158/0008-5472.284.65.1
Autor:
Graham Molineux
Publikováno v:
Pharmacotherapy. 23:3S-8S
Pegylation, the technology of polyethylene glycol (PEG) conjugation, holds significant promise in maintaining effective plasma concentrations of systemically administered drugs that might otherwise be hampered in vivo by a number of factors, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3ec0f96c7e8bed73f3f5ced5187ae3
https://doi.org/10.1592/phco.23.9.3s.32886
https://doi.org/10.1592/phco.23.9.3s.32886
Autor:
Henry Schultz, Weston Sutherland, Anne C. Heatherington, Raheem Khaja, C. Glenn Begley, Steve Elliott, Juan Del Castillo, Patricia McElroy, Cynthia Hartley, Graham Molineux, Tom Graves
Publikováno v:
British Journal of Haematology. 122:623-636
Summary. Despite its frequency and impact on clinical outcomes, anaemia in cancer patients remains poorly understood and suboptimally treated. The definition of optimum treatment schedules with erythropoietic agents requires a suitable model of chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6e35ff957f61e3d9e9a75b68afcf6ff
https://doi.org/10.1046/j.1365-2141.2003.04467.x
https://doi.org/10.1046/j.1365-2141.2003.04467.x