Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Graham McLennan"'
Autor:
Erica Soster, John Tynan, Clare Gibbons, Wendy Meschino, Jenna Wardrop, Eyad Almasri, Stuart Schwartz, Graham McLennan
Publikováno v:
Molecular Cytogenetics, Vol 16, Iss 1, Pp 1-12 (2023)
Abstract Background Noninvasive prenatal testing (NIPT) allows for screening of fetal aneuploidy and copy number variants (CNVs) from cell-free DNA (cfDNA) in maternal plasma. Professional societies have not yet embraced NIPT for fetal CNVs, citing a
Externí odkaz:
https://doaj.org/article/8bbb53f309e648bab641ae0bcbbe991b
Autor:
Jill Rafalko, Samantha Caldwell, Erica Soster, Eyad Almasri, Graham McLennan, Tong Liu, Vivian Weinblatt, Philip Cacheris, Ron McCullough
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248467 (2021)
Mosaicism ratio, or MR, is a laboratory metric that can be calculated using massively parallel sequencing data from cell-free DNA (cfDNA) screening. MR compares the amount of cfDNA present from a particular chromosome or chromosomal region to the ove
Externí odkaz:
https://doaj.org/article/b3da4f7e39a94fcea4bd35a09e896c77
Autor:
Adriana Aguilar-Mahecha, Josiane Lafleur, Susie Brousse, Olga Savichtcheva, Kimberly A. Holden, Nathan Faulkner, Graham McLennan, Taylor J. Jensen, Mark Basik
Publikováno v:
Cancers, Vol 13, Iss 6, p 1331 (2021)
Background: Circulating tumor DNA (ctDNA) offers high sensitivity and specificity in metastatic cancer. However, many ctDNA assays rely on specific mutations in recurrent genes or require the sequencing of tumor tissue, difficult to do in a metastati
Externí odkaz:
https://doaj.org/article/c4fd99fa4ded4acf91d4360c490d7ffe
Autor:
Taylor J Jensen, Tricia Zwiefelhofer, Roger C Tim, Željko Džakula, Sung K Kim, Amin R Mazloom, Zhanyang Zhu, John Tynan, Tim Lu, Graham McLennan, Glenn E Palomaki, Jacob A Canick, Paul Oeth, Cosmin Deciu, Dirk van den Boom, Mathias Ehrich
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57381 (2013)
Circulating cell-free (ccf) fetal DNA comprises 3-20% of all the cell-free DNA present in maternal plasma. Numerous research and clinical studies have described the analysis of ccf DNA using next generation sequencing for the detection of fetal aneup
Externí odkaz:
https://doaj.org/article/78d3d7087d2344168e14150bfa8beb58
Autor:
Razelle Kurzrock, Mathias Ehrich, Daniel S. Grosu, Graham McLennan, Amin R. Mazloom, Erin McCarthy, Prachi Nakashe, Lisa Kim, Gregory A. Daniels, Christopher K. Ellison, Shumei Kato, Aaron M. Goodman, Taylor J. Jensen
Supplementary Table 1. Patient clinical characteristics (N=44 patients). *PFS values with a (+) indicate response is ongoing at time of data censoring Abbreviations: cfDNA = cell-free DNA; CR = complete response; GE = gene equivalents per mL; GE junc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f6fe87d54e7b101f7d0bd5f70e485f
https://doi.org/10.1158/1535-7163.22507854.v1
https://doi.org/10.1158/1535-7163.22507854.v1
Autor:
Razelle Kurzrock, Mathias Ehrich, Daniel S. Grosu, Graham McLennan, Amin R. Mazloom, Erin McCarthy, Prachi Nakashe, Lisa Kim, Gregory A. Daniels, Christopher K. Ellison, Shumei Kato, Aaron M. Goodman, Taylor J. Jensen
Inhibitors of the PD-1/PD-L1/CTLA-4 immune checkpoint pathway have revolutionized cancer treatment. Indeed, some patients with advanced, refractory malignancies achieve durable responses; however, only a subset of patients benefit, necessitating new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f10a1990e404d66946996eef099fec7
https://doi.org/10.1158/1535-7163.c.6538806
https://doi.org/10.1158/1535-7163.c.6538806
Autor:
Lorraine Dugoff, Nathanael C. Koelper, Stephen T. Chasen, Melissa L. Russo, Ashley S. Roman, Meghana A. Limaye, Angela C. Ranzini, Caitlin M. Clifford, Joseph R. Biggio, Akila Subramaniam, Angela Seasely, Avinash S. Patil, Samantha Weed, Jessica M. Page, Sara Nicholas, Jay Idler, Rashmi R. Rao, Amber Crowder, Raj Shree, Graham McLennan, Bryann Bromley
Publikováno v:
American Journal of Obstetrics and Gynecology.
Autor:
Graham McLennan, Amin Mazloom, Gregory A. Daniels, Daniel S. Grosu, Marcia Eisenberg, Razelle Kurzrock, Kimberly A. Holden, Shumei Kato, Prachi Nakashe, Kerry D. Fitzgerald, Eyad Almasri, Taylor J. Jensen, Christopher K. Ellison, Erin McCarthy, Lisa Kim, Aaron M. Goodman
Publikováno v:
Molecular Cancer Therapeutics. 20:2274-2279
When tissue biopsy is not medically prudent or tissue is insufficient for molecular testing, alternative methods are needed. Because cell-free DNA (cfDNA) has been shown to provide a representative surrogate for tumor tissue, we sought to evaluate it
Autor:
Dimitrios Tzachanis, Razelle Kurzrock, Taylor J. Jensen, Amin Haghighat Jahromi, Aaron M. Goodman, Graham McLennan, Marcia Eisenberg, Lisa Kim, Edward D. Ball, Ah Reum Jeong, Carolyn Mulroney, Eyad Almasri, Kimberly A. Holden, Kerry D. Fitzgerald, Carl K. Hoh, Michael Hurley
Publikováno v:
Transplantation and cellular therapy. 28(1)
Methods that enable monitoring of therapeutic efficacy of autologous chimeric antigen receptor (CAR) T-cell therapy will be clinically useful. The aim of this study is to demonstrate the feasibility of blood-derived cell-free DNA (cfDNA) to predict C
Autor:
Lorraine Dugoff, Nathanael C. Koelper, Stephen T. Chasen, Melissa L. Russo, Ashley S. Roman, Meghana A. Limaye, Angela Ranzini, Caitlin Clifford, Joseph R. Biggio, Akila Subramaniam, Angela R. Seasely, Avi Patil, Samantha Weed, Jessica Page, Sara Nicholas, Ciara Talbot, Rashmi Rao, Amber Crowder, Raj S. Shree, Graham McLennan, Bryann Bromley
Publikováno v:
American Journal of Obstetrics and Gynecology. 226:S437-S438