Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Graham Marsh"'
Autor:
Mootaz M. Salman, Graham Marsh, Ilja Kusters, Matthieu Delincé, Giuseppe Di Caprio, Srigokul Upadhyayula, Giovanni de Nola, Ronan Hunt, Kazuka G. Ohashi, Taylor Gray, Fumitaka Shimizu, Yasuteru Sano, Takashi Kanda, Birgit Obermeier, Tom Kirchhausen
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
We describe here the design and implementation of an in vitro microvascular open model system using human brain microvascular endothelial cells. The design has several advantages over other traditional closed microfluidic platforms: (1) it enables co
Externí odkaz:
https://doaj.org/article/a59750942c61446cad7b10bfa96a0dad
Autor:
Nienke R. Wevers, Dhanesh G. Kasi, Taylor Gray, Karlijn J. Wilschut, Benjamin Smith, Remko van Vught, Fumitaka Shimizu, Yasuteru Sano, Takashi Kanda, Graham Marsh, Sebastiaan J. Trietsch, Paul Vulto, Henriëtte L. Lanz, Birgit Obermeier
Publikováno v:
Fluids and Barriers of the CNS, Vol 15, Iss 1, Pp 1-12 (2018)
Abstract Background Receptor-mediated transcytosis is one of the major routes for drug delivery of large molecules into the brain. The aim of this study was to develop a novel model of the human blood–brain barrier (BBB) in a high-throughput microf
Externí odkaz:
https://doaj.org/article/9a670cc2537543efb3a82377ecf0d4a8
Autor:
Raysa Khan, Graham Marsh, Robert Felix, Paul D. Kemmitt, Matthias G. J. Baud, Alessio Ciulli, John Spencer
Publikováno v:
ACS Omega, Vol 2, Iss 8, Pp 4328-4332 (2017)
Externí odkaz:
https://doaj.org/article/7e439ba1cfaf4f858713a7fd575c437d
Publikováno v:
Biophys J
The endothelial glycocalyx layer (EGL), which consists of long proteoglycans protruding from the endothelium, acts as a regulator of inflammation by preventing leukocyte engagement with adhesion molecules on the endothelial surface. The amount of res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8441b2c0d1812be280aee995f2227b
https://doi.org/10.1016/j.bpj.2020.02.010
https://doi.org/10.1016/j.bpj.2020.02.010
Autor:
Tom Kirchhausen, Srigokul Upadhyayula, Giuseppe Di Caprio, Graham Marsh, Ilja Kusters, Ronan Hunt, Birgit Obermeier, Giovanni de Nola, Mootaz M. Salman, Kazuka G. Ohashi, Fumitaka Shimizu, Takashi Kanda, Matthieu Delince, Yasuteru Sano
We describe here the design and implementation of anin-vitroBBB-on-a-chip open model system capable of reconstituting the microenvironment of the blood brain barrier. This system allows controlled unidirectional flow of nutrients and biologicals on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df36d84e12a577e4375a266c9414892f
https://doi.org/10.1101/2020.06.30.175380
https://doi.org/10.1101/2020.06.30.175380
Autor:
Lionel Feigenbaum, Jeremy S. Duffield, Zebulon G. Levine, Bryce G. Johnson, Deepak Reyon, Lan T.H. Dang, Allie M. Roach, Anthony Monti, Graham Marsh
Publikováno v:
Journal of Clinical Investigation. 127:3954-3969
Uromodulin-associated kidney disease (UAKD) is caused by mutations in the uromodulin (UMOD) gene that result in a misfolded form of UMOD protein, which is normally secreted by nephrons. In UAKD patients, mutant UMOD is poorly secreted and accumulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876d471f031eda85e7264dc1615f5b7f
https://doi.org/10.1172/jci93817
https://doi.org/10.1172/jci93817
Autor:
Angela Huang, Chris Sparages, Roberto F. Nicosia, Jeremy S. Duffield, Lan T.H. Dang, Christopher S. Chen, Sarah Kate Read, Christine Yoon, Takahide Aburatani, Graham Marsh, Stella Alimperti, Suzanne Szak, Naoki Nakagawa, Ivan G. Gomez, Bryce G. Johnson, Shuyu Ren, Giovanni Ligresti, Alfred C. Aplin
Publikováno v:
Biomaterials. 141:314-329
Loss of the microvascular (MV) network results in tissue ischemia, loss of tissue function, and is a hallmark of chronic diseases. The incorporation of a functional vascular network with that of the host remains a challenge to utilizing engineered ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25560b26fb7f4837134bf438132270a9
https://doi.org/10.1016/j.biomaterials.2017.07.010
https://doi.org/10.1016/j.biomaterials.2017.07.010
Autor:
Graham Marsh, Ioannis Zampetakis, Danielle S. W. Benoit, Kristen Harding, Richard E. Waugh, Kanika Vats
Publikováno v:
Journal of Biomedical Materials Research Part A. 105:1112-1122
Poly(ethylene glycol) (PEG) hydrogels provide a versatile platform to develop cell instructive materials through incorporation of a variety of cell adhesive ligands and degradable chemistries. Synthesis of PEG gels can be accomplished via two mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27abfa8af8479652f6454fb064719f36
https://doi.org/10.1002/jbm.a.36007
https://doi.org/10.1002/jbm.a.36007
Autor:
János Peti-Peterdi, Giovanni Ligresti, Ivan G. Gomez, Takahide Aburatani, Jeremy S. Duffield, Dario R. Lemos, Angela Huang, Gabriela Campanholle, Graham Marsh, Ken Fisher, Lan T.H. Dang
Publikováno v:
American Journal of Physiology-Renal Physiology. 311:F1230-F1242
Pericytes are tissue-resident mesenchymal progenitor cells anatomically associated with the vasculature that have been shown to participate in tissue regeneration. Here, we tested the hypothesis that kidney pericytes, derived from FoxD1+ mesodermal p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eab67ee8b2bbfbabf6809fc11d842e6
https://doi.org/10.1152/ajprenal.00030.2016
https://doi.org/10.1152/ajprenal.00030.2016
Autor:
Graham Marsh, Richard E. Waugh
Publikováno v:
Journal of Microscopy. 262:245-251
Summary When investigating the interaction of cells with surfaces, it is becoming increasingly important to perform quantitative measurements of surface protein density to understand reaction kinetics. Previously, to calibrate a surface for an experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fe5b81dfd4f9b9b3aec47867461e2c6
https://doi.org/10.1111/jmi.12358
https://doi.org/10.1111/jmi.12358