Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Graham M. West"'
Autor:
Andrea M. Zuhl, Charles E. Nolan, Michael A. Brodney, Sherry Niessen, Kevin Atchison, Christopher Houle, David A. Karanian, Claude Ambroise, Jeffrey W. Brulet, Elizabeth M. Beck, Shawn D. Doran, Brian T. O’Neill, Christopher W. am Ende, Cheng Chang, Kieran F. Geoghegan, Graham M. West, Joshua C. Judkins, Xinjun Hou, David R. Riddell, Douglas S. Johnson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Several β-secretase (BACE) inhibitors exhibit unexplained ocular toxicity in preclinical studies. Here the authors generate a clickable photoaffinity probe to interrogate off-targets in cells and animals, and identify inhibition of cathepsin D as a
Externí odkaz:
https://doaj.org/article/5dfe4a29e6af43a49ee6c24207abc513
Autor:
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S. Chang, Stephen Noell, Timothy L. Foley, Hyejin Yoon, Kathleen Smith, Shoh Asano, Katherine Hales, Min Wan, Qingyi Yang, Mary A. Piotrowski, Kathleen A. Farley, Tamara Gilbert, Lisa M. Aschenbrenner, Kimberly F. Fennell, Jason K. Dutra, Mary Xu, Chunyang Guo, Alison E. Varghese, Justin Bellenger, Alandra Quinn, Christopher W. am Ende, Graham M. West, Matthew C. Griffor, Donald Bennett, Matthew Calabrese, Claire M. Steppan, Seungil Han, Huixian Wu
Publikováno v:
Nature Structural & Molecular Biology. 30:22-30
Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis. Hepatic expression of GPAT1 is linked to liver fat accumulation and the severity of nonalcoholi
Autor:
Xiaodi Yu, Olga Plotnikova, Paul D Bonin, Timothy A Subashi, Thomas J McLellan, Darren Dumlao, Ye Che, Yin Yao Dong, Elisabeth P Carpenter, Graham M West, Xiayang Qiu, Jeffrey S Culp, Seungil Han
Publikováno v:
eLife, Vol 8 (2019)
Alanine-serine-cysteine transporter 2 (ASCT2, SLC1A5) is the primary transporter of glutamine in cancer cells and regulates the mTORC1 signaling pathway. The SLC1A5 function involves finely tuned orchestration of two domain movements that include the
Externí odkaz:
https://doaj.org/article/a33c8724acd14c1bb4ac82ee1b35322f
Publikováno v:
ACS chemical biology. 16(8)
Stability proteomics techniques that do not require drug modifications have emerged as an attractive alternative to affinity purification methods in drug target engagement studies. Two representative techniques include the chemical-denaturation-based
Autor:
Graham M West, Francis S Willard, Kyle W Sloop, Aaron D Showalter, Bruce D Pascal, Patrick R Griffin
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e105683 (2014)
Activation of the glucagon-like peptide-1 receptor (GLP-1R) in pancreatic β-cells potentiates insulin production and is a current therapeutic target for the treatment of type 2 diabetes mellitus (T2DM). Like other class B G protein-coupled receptors
Externí odkaz:
https://doaj.org/article/041fff9bc52e4843b0f9ce5af37eab12
Publikováno v:
Organicbiomolecular chemistry. 18(19)
A C–H functionalization strategy for the expedient access to photoreactive chemical probes of commonly found heterocyclic fragments or drug molecules of pharmaceutical relevance is described. A series of aryl glyoxylic acid reagents featuring penda
Autor:
Xiayang Qiu, Olga Plotnikova, Thomas J. McLellan, Graham M. West, Timothy A. Subashi, Y.Y. Dong, Elisabeth P. Carpenter, Seungil Han, Darren Dumlao, Paul D. Bonin, Xiaodi Yu, Ye Che, Jeffrey S. Culp
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Alanine-serine-cysteine transporter 2 (ASCT2, SLC1A5) is the primary transporter of glutamine in cancer cells and regulates the mTORC1 signaling pathway. The SLC1A5 function involves finely tuned orchestration of two domain movements that include the
Autor:
Olga Plotnikova, Jeffrey S. Culp, Thomas J. McLellan, Y.Y. Dong, Darren Dumlao, Xiayang Qiu, Xiaodi Yu, Ye Che, Elisabeth P. Carpenter, Graham M. West, Paul D. Bonin, Timothy A. Subashi, Seungil Han
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6535cfe5652486f9831ba6924fd7aee
https://doi.org/10.7554/elife.48120.027
https://doi.org/10.7554/elife.48120.027
Autor:
Xiayang Qiu, Jeffrey S. Culp, Yinyao Dong, Darren Dumlao, Xiaodi Yu, Thomas J. McLellan, Ye Che, Paul D. Bonin, Olga Plotnikova, Elisabeth P. Carpenter, Seungil Han, Graham M. West, Timothy A. Subashi
Alanine-serine-cysteine transporter 2 (ASCT2, SLC1A5) is the primary transporter of glutamine in cancer cells and regulates the mTORC1 signaling pathway. The SLC1A5 function involves finely tuned orchestration of two domain movements that include the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e375ab389a77edbb643aca03e7e020
https://doi.org/10.1101/622563
https://doi.org/10.1101/622563
Publikováno v:
MedChemComm. 7:769-777
Phenotypic screening is a powerful strategy for identifying active molecules with particular biological effects in cellular or animal disease models. Functionalized chemical probes have been instrumental in revealing new targets and confirming target