Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Graham M, Lord"'
Autor:
Jonathan W. Lo, Domenico Cozzetto, James L. Alexander, Nathan P. Danckert, Matthew Madgwick, Naomi Knox, Jillian Yong Xin Sieh, Marton Olbei, Zhigang Liu, Hajir Ibraheim, Jesus Miguens Blanco, Hiromi Kudo, Rocio Castro Seoane, Lucia A. Possamai, Robert Goldin, Julian Marchesi, Tamas Korcsmaros, Graham M. Lord, Nick Powell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Immune checkpoint inhibitors (CPIs) are a relatively newly licenced cancer treatment, which make a once previously untreatable disease now amenable to a potential cure. Combination regimens of anti-CTLA4 and anti-PD-1 show enhanced efficacy
Externí odkaz:
https://doaj.org/article/e664d0e3c68643ff903f07ec1b951c4e
Autor:
Polychronis Pavlidis, Anastasia Tsakmaki, Eirini Pantazi, Katherine Li, Domenico Cozzetto, Jonathan Digby- Bell, Feifei Yang, Jonathan W. Lo, Elena Alberts, Ana Caroline Costa Sa, Umar Niazi, Joshua Friedman, Anna K. Long, Yuchun Ding, Christopher D. Carey, Christopher Lamb, Mansoor Saqi, Matthew Madgwick, Leila Gul, Agatha Treveil, Tamas Korcsmaros, Thomas T. Macdonald, Graham M. Lord, Gavin Bewick, Nick Powell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Mechanisms of non-response to ustekinumab, a biologic targeting IL-23, are currently unclear. Here, the authors show that the transcriptional program regulated by IL-22, an IL-23 responsive cytokine, is enriched in patients with ulcerative colitis un
Externí odkaz:
https://doaj.org/article/09b1e8f2868c4b6694a41d33bf89af3b
Autor:
Jan-Hendrik Schroeder, Gordon Beattie, Jonathan W. Lo, Tomasz Zabinski, Nick Powell, Joana F. Neves, Richard G. Jenner, Graham M. Lord
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Huge progress has been made in understanding the biology of innate lymphoid cells (ILC) by adopting several well-known concepts in T cell biology. As such, flow cytometry gating strategies and markers, such as CD90, have been applied to indentify ILC
Externí odkaz:
https://doaj.org/article/51f45fc4faa84fa3900e89aef90a55fc
Autor:
Luke B. Roberts, Rita Berkachy, Madina Wane, Dhiren F. Patel, Corinna Schnoeller, Graham M. Lord, Kleoniki Gounaris, Bernhard Ryffel, Valerie Quesniaux, Matthew Darby, William G. C. Horsnell, Murray E. Selkirk
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Acetylcholine (ACh) from neuronal and non-neuronal sources plays an important role in the regulation of immune responses and is associated with the development of several disease pathologies. We have previously demonstrated that group 2 innate lympho
Externí odkaz:
https://doaj.org/article/addf3507d9c04285aa718ea4f45c3755
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cardiovascular diseases (CVDs) are responsible for most pre-mature deaths worldwide, contributing significantly to the global burden of disease and its associated costs to individuals and healthcare systems. Obesity and associated metabolic inflammat
Externí odkaz:
https://doaj.org/article/8125cdbe8805414590e47dc030760b2d
Autor:
Amit Kaura, Adam Hartley, Vasileios Panoulas, Ben Glampson, Anoop S V Shah, Jim Davies, Abdulrahim Mulla, Kerrie Woods, Joe Omigie, Anoop D Shah, Mark R Thursz, Paul Elliott, Harry Hemmingway, Bryan Williams, Folkert W Asselbergs, Michael O'Sullivan, Graham M Lord, Adam Trickey, Jonathan Ac Sterne, Dorian O Haskard, Narbeh Melikian, Darrel P Francis, Wolfgang Koenig, Ajay M Shah, Rajesh Kharbanda, Divaka Perera, Riyaz S Patel, Keith M Channon, Jamil Mayet, Ramzi Khamis
Publikováno v:
PLoS Medicine, Vol 19, Iss 2, p e1003911 (2022)
BackgroundThere is limited evidence on the use of high-sensitivity C-reactive protein (hsCRP) as a biomarker for selecting patients for advanced cardiovascular (CV) therapies in the modern era. The prognostic value of mildly elevated hsCRP beyond tro
Externí odkaz:
https://doaj.org/article/ec5e369770594818bb3c10e2121250ab
Autor:
Jan-Hendrik Schroeder, Luke B. Roberts, Katrin Meissl, Jonathan W. Lo, Dominika Hromadová, Kelly Hayes, Tomasz Zabinski, Emily Read, Catarina Moreira Heliodoro, Rita Reis, Jane K. Howard, Richard K. Grencis, Joana F. Neves, Birgit Strobl, Graham M. Lord
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Innate lymphoid cells (ILC) play a significant role in the intestinal immune response and T-bet+ CD127+ group 1 cells (ILC1) have been linked to the pathogenesis of human inflammatory bowel disease (IBD). However, the functional importance of ILC1 in
Externí odkaz:
https://doaj.org/article/5e18d42e0aa843848e7f5977f4051c1e
Autor:
Luca G. Campana, Wasat Mansoor, James Hill, Christian Macutkiewicz, Finlay Curran, David Donnelly, Ben Hornung, Peter Charleston, Robert Bristow, Graham M. Lord, Sara Valpione
Publikováno v:
Cancers, Vol 14, Iss 23, p 5883 (2022)
Predicting the survival outcomes of patients with colorectal cancer (CRC) remains challenging. We investigated the prognostic significance of the transcriptome and tumour-infiltrating lymphocyte T-cell receptor (TIL/Tc-TCR) repertoire and analysed TI
Externí odkaz:
https://doaj.org/article/dac29162dffd45f8891369cf813115cb
Autor:
Marija Zaric, Pablo D. Becker, Catherine Hervouet, Petya Kalcheva, Andor Doszpoly, Negin Blattman, Lauren A. O’ Neill, Barbara Ibarzo Yus, Clement Cocita, Sung-Yun Kwon, Andrew H. Baker, Graham M. Lord, Linda S. Klavinskis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Mucosal immunisation is important for initiating mucosal CD8+ Tcell responses but mucosal recruitment of protective CD8+ T cells can also be induced by skin immunisation. Here the authors examine the underlying mechanism and report a novel role for
Externí odkaz:
https://doaj.org/article/50310e1b618c4e9db13be9368bb83233
Autor:
Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Tjir-Li Tsui, Claire Duff, Clara Domingo-Vila, Yogesh Kamra, Florence Delaney, Rosa Montero, Anastasia Spiridou, Theodoros Kassimatis, Sui Phin-Kon, Beatriz Tucker, Christopher Farmer, Terry B. Strom, Graham M. Lord, Irene Rebollo-Mesa, Daniel Stahl, Steven Sacks, Maria P. Hernandez-Fuentes, Paramit Chowdhury
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 571-583 (2019)
Background: Acute T-cell mediated rejection (TCMR) is usually indicated by alteration in serum-creatinine measurements when considerable transplant damage has already occurred. There is, therefore, a need for non-invasive early detection of immune si
Externí odkaz:
https://doaj.org/article/dbd47bb0ad88471a9010ab59f2dad071