Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infants

Autor: Rhea Urs, Rubi Ni Chin, Naomi Hemy, Andrew C. Wilson, J. Jane Pillow, Graham L. Hall, Shannon J. Simpson

Publikováno v: BMC Pediatrics, Vol 23, Iss 1, Pp 1-9 (2023)

Abstract Background Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed to assess if inflammatory markers we

Externí odkaz: https://doaj.org/article/173e652457454ac3b499a31fe588d238

The ventilatory response to hypoxia is blunted in some preterm infants during the second year of life

Autor: Zoe Freislich, Benjamin Stoecklin, Naomi Hemy, J. Jane Pillow, Graham L. Hall, Andrew C. Wilson, Shannon J. Simpson

Publikováno v: Frontiers in Pediatrics, Vol 10 (2022)

BackgroundPreterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic ventilatory response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether the attenuation persists in

Externí odkaz: https://doaj.org/article/c5dce4c51a9143edbdeedcdad5db0c01

Clinical significance and applications of oscillometry

Autor: David A. Kaminsky, Shannon J. Simpson, Kenneth I. Berger, Peter Calverley, Pedro L. de Melo, Ronald Dandurand, Raffaele L. Dellacà, Claude S. Farah, Ramon Farré, Graham L. Hall, Iulia Ioan, Charles G. Irvin, David W. Kaczka, Gregory G. King, Hajime Kurosawa, Enrico Lombardi, Geoffrey N. Maksym, François Marchal, Ellie Oostveen, Beno W. Oppenheimer, Paul D. Robinson, Maarten van den Berge, Cindy Thamrin

Publikováno v: European Respiratory Review, Vol 31, Iss 163 (2022)

Recently, “Technical standards for respiratory oscillometry” was published, which reviewed the physiological basis of oscillometric measures and detailed the technical factors related to equipment and test performance, quality assurance and repor

Externí odkaz: https://doaj.org/article/0f6fb29b53f245f7b16952e5846ea575

Variants associated with HHIP expression have sex-differential effects on lung function [version 2; peer review: 2 approved]

Autor: Katherine A. Fawcett, Ma'en Obeidat, Carl Melbourne, Nick Shrine, Anna L. Guyatt, Catherine John, Jian'an Luan, Anne Richmond, Marta R. Moksnes, Raquel Granell, Stefan Weiss, Medea Imboden, Sebastian May-Wilson, Pirro Hysi, Thibaud S. Boutin, Laura Portas, Claudia Flexeder, Sarah E. Harris, Carol A. Wang, Leo-Pekka Lyytikäinen, Teemu Palviainen, Rachel E. Foong, Dirk Keidel, Cosetta Minelli, Claudia Langenberg, Yohan Bossé, Maarten Van den Berge, Don D. Sin, Ke Hao, Archie Campbell, David Porteous, Sandosh Padmanabhan, Blair H. Smith, David M. Evans, Sue Ring, Arnulf Langhammer, Kristian Hveem, Cristen Willer, Ralf Ewert, Beate Stubbe, Nicola Pirastu, Lucija Klaric, Peter K. Joshi, Karina Patasova, Mangino Massimo, Ozren Polasek, John M. Starr, Stefan Karrasch, Konstantin Strauch, Thomas Meitinger, Igor Rudan, Taina Rantanen, Kirsi Pietiläinen, Mika Kähönen, Olli T. Raitakari, Graham L. Hall, Peter D. Sly, Craig E. Pennell, Jaakko Kaprio, Terho Lehtimäki, Veronique Vitart, Ian J. Deary, Debbie Jarvis, James F. Wilson, Tim Spector, Nicole Probst-Hensch, Nicholas J. Wareham, Henry Völzke, John Henderson, David P. Strachan, Ben M. Brumpton, Caroline Hayward, Ian P. Hall, Martin D. Tobin, Louise V. Wain

Publikováno v: Wellcome Open Research, Vol 5 (2021)

Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study

Externí odkaz: https://doaj.org/article/4b05913ad06e4e1882f53a780230d2ab

Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics

Autor: Anya C. Jones, Niamh M. Troy, Elisha White, Elysia M. Hollams, Alexander M. Gout, Kak-Ming Ling, Anthony Kicic, Stephen M. Stick, Peter D. Sly, Patrick G. Holt, Graham L. Hall, Anthony Bosco

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

Abstract Atopic asthma is a persistent disease characterized by intermittent wheeze and progressive loss of lung function. The disease is thought to be driven primarily by chronic aeroallergen-induced type 2-associated inflammation. However, the vast

Externí odkaz: https://doaj.org/article/3ac16e7684d348ea85dff8c594b24574