Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Graham K. Farrington"'
Autor:
Danica Stanimirovic, Eric Brunette, Tammy-Lynn Tremblay, Ewa Baumann, John Eldredge, William P. Sisk, Arsalan S. Haqqani, Wen Ding, Graham K. Farrington, Christie Delaney
Current methods for examining antibody trafficking are either non-quantitative such as immunocytochemistry or require antibody labeling with tracers. We have developed a multiplexed quantitative method for antibody ‘tracking’ in endosomal compart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1dd379418510018f0d6464f63158237
https://europepmc.org/articles/PMC5888858/
https://europepmc.org/articles/PMC5888858/
Autor:
Lee Walus, Sha Mi, Steven A. Berkowitz, Allan D. Capili, Ellen Garber, Laura Silvian, John Eldredge, R. Blake Pepinsky, Christilyn Graff, Graham K. Farrington, Alexey Lugovskoy
Publikováno v:
Protein Science. 19:954-966
Monoclonal antibodies (Mabs) are a favorite drug platform of the biopharmaceutical industry. Currently, over 20 Mabs have been approved and several hundred others are in clinical trials. The anti-LINGO-1 Mab Li33 was selected from a large panel of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55e42f07c07b277c2c4ff12adfca9855
https://doi.org/10.1002/pro.372
https://doi.org/10.1002/pro.372
Autor:
Alan F. Corin, John Eldredge, Mohammad Zafari, Madhavi Tadi, Kathy Strauch, Werner Meier, Steven A. Berkowitz, Eric S. Day, David Hayes, Graham K. Farrington
Publikováno v:
Biochemistry. 45:10117-10128
LTβR is a member of the TNF receptor family of proteins. It binds to two different cell surface ligands, LIGHT, a homotypic trimer, and LTα1β2, a heterotypic trimer. We have measured the affinities of the dimeric IgG fusion protein, LTβRIgG, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e454185da2674014ce9be2f988f15ee
https://doi.org/10.1021/bi060210+
https://doi.org/10.1021/bi060210+
Autor:
Graham K. Farrington, Jessica E. Friedman, Joshua C. Yoburn, Alexey Lugovskoy, William Michael Flanagan, Stephan K. Miller, Brian C. Cunningham, Amy D. Fung, Adrian Whitty, Molly M. He, Jun Wang, Annemarie Stroustrup Smith, Mark T. Cancilla, John Eldredge, Leslie A. Cruz, Johan D. Oslob, Teresa G. Cachero, Andrew C. Braisted, Eric S. Day, Ingrid C. Choong
Publikováno v:
Science. 310:1022-1025
We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that promotes subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-α activity in biochemical and cell-based assays with median inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a6ce3328b91c59024e2eaf119ff3ef0
https://doi.org/10.1126/science.1116304
https://doi.org/10.1126/science.1116304
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 71
The development and approval of antibody-based therapeutics have progressed rapidly over the past decade. However, poor blood-brain barrier (BBB) permeability hinders the progress of antibody therapies for conditions in which the target is located in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47974d85e17abd96ff88a9733508e3b8
https://pubmed.ncbi.nlm.nih.gov/25307221
https://pubmed.ncbi.nlm.nih.gov/25307221
Autor:
Giovanna Antognetti, William P. Sisk, Arsalan S. Haqqani, Eve Boileau, John Eldredge, Wen Ding, Ewa Baumann, Pepinsky R Blake, Graham K. Farrington, Danica Stanimirovic, Ellen Garber, Nadia L. Caram-Salas, Eric Brunette, Christie Delaney, Susan Jiang
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(11)
The blood-brain barrier (BBB) prevents the access of therapeutic antibodies to central nervous system (CNS) targets. The engineering of bispecific antibodies in which a therapeutic "arm" is combined with a BBB-transcytosing arm can significantly enha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c377da1d76b1d1100774ace351491a74
https://pubmed.ncbi.nlm.nih.gov/25070367
https://pubmed.ncbi.nlm.nih.gov/25070367
Autor:
Nadia, Caram-Salas, Eve, Boileau, Graham K, Farrington, Ellen, Garber, Eric, Brunette, Abedelnasser, Abulrob, Danica, Stanimirovic
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 763
The neonatal Fc receptor, FcRn, mediates endocytic recycling pathway that prevents degradation of IgG and is expressed in most endothelial cells. The blood-brain barrier (BBB), formed by brain endothelial cells sealed with tight junctions, restricts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef416f4394ff123b7b0ff6d2d68258af
https://pubmed.ncbi.nlm.nih.gov/21874466
https://pubmed.ncbi.nlm.nih.gov/21874466
Autor:
Graham K. Farrington, Danica Stanimirovic, Eve Boileau, Ellen Garber, Nadia L. Caram-Salas, Abedelnasser Abulrob, Eric Brunette
Publikováno v:
Methods in Molecular Biology ISBN: 9781617791901
The neonatal Fc receptor, FcRn, mediates endocytic recycling pathway that prevents degradation of IgG and is expressed in most endothelial cells. The blood-brain barrier (BBB), formed by brain endothelial cells sealed with tight junctions, restricts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed09b5a5d9e51573a90539adc7b4f662
https://doi.org/10.1007/978-1-61779-191-8_26
https://doi.org/10.1007/978-1-61779-191-8_26
Publikováno v:
The FASEB Journal. 24
Engineered bispecific and tetravalent IgG-like antibodies that engage multiple target epitopes represent promising new classes of therapeutic agents. To address their intrinsic low stability and hi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e76954fea75f5731a954694528497cdb
https://doi.org/10.1096/fasebj.24.1_supplement.415.2
https://doi.org/10.1096/fasebj.24.1_supplement.415.2
Autor:
Graham K. Farrington, Samantha Phan, Sharon X. Gao, Adam Doern, Xiufeng Wu, Flora Huang, Aldo Amatucci, Ellen Garber, Veronique Bailly, Alexey Lugovskoy, Scott Glaser, Stephen Demarest, Jeffrey L. Browning, Xin Wang, William B. Snyder, Jennifer S. Michaelson, Ingrid Joseph, Brian Robert Miller
Bispecific antibodies (BsAbs) represent an emerging class of biologics that achieve dual targeting with a single agent. Recombinant DNA technologies have facilitated a variety of creative bispecific designs with many promising therapeutic application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474354b9747d2cb5d9884bdfcd58764d
https://europepmc.org/articles/PMC2725416/
https://europepmc.org/articles/PMC2725416/