Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Graham J. Moore"'
Autor:
Harry Ridgway, Vasso Apostolopoulos, Graham J. Moore, Laura Kate Gadanec, Anthony Zulli, Jordan Swiderski, Sotirios Tsiodras, Konstantinos Kelaidonis, Christos T. Chasapis, John M. Matsoukas
Publikováno v:
Viruses, Vol 16, Iss 11, p 1776 (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza, and respiratory syncytial virus (RSV) are significant global health threats. The need for low-cost, easily synthesized oral drugs for rapid deployment during outbreaks is crucia
Externí odkaz:
https://doaj.org/article/effde1e4cc9546c1a3d7ad1ab0fc4087
Autor:
Harry Ridgway, John D. Orbell, Minos-Timotheos Matsoukas, Konstantinos Kelaidonis, Graham J. Moore, Sotiris Tsiodras, Vasilis G. Gorgoulis, Christos T. Chasapis, Vasso Apostolopoulos, John M. Matsoukas
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4589-4612 (2023)
Furins are serine endoproteases that process precursor proteins into their biologically active forms, and they play essential roles in normal metabolism and disease presentation, including promoting expression of bacterial virulence factors and viral
Externí odkaz:
https://doaj.org/article/c49dea784d9c4b30b61faf8fe083263b
Autor:
Harry Ridgway, Graham J. Moore, Thomas Mavromoustakos, Sotirios Tsiodras, Irene Ligielli, Konstantinos Kelaidonis, Christos T. Chasapis, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, Russell Petty, Ioannis Karakasiliotis, Vassilis G. Gorgoulis, John M. Matsoukas
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2091-2111 (2022)
The discovery and facile synthesis of a new class of sartan-like arterial antihypertensive drugs (angiotensin receptor blockers [ARBs]), subsequently referred to as “bisartans” is reported. In vivo results and complementary molecular modelling pr
Externí odkaz:
https://doaj.org/article/c273711c046740748e8c42638b922ec3
Autor:
Despoina P. Kiouri, Charalampos Ntallis, Konstantinos Kelaidonis, Massimiliano Peana, Sotirios Tsiodras, Thomas Mavromoustakos, Alessandro Giuliani, Harry Ridgway, Graham J. Moore, John M. Matsoukas, Christos T. Chasapis
Publikováno v:
Proteomes, Vol 11, Iss 2, p 21 (2023)
The potential of targeting the Renin-Angiotensin-Aldosterone System (RAAS) as a treatment for the coronavirus disease 2019 (COVID-19) is currently under investigation. One way to combat this disease involves the repurposing of angiotensin receptor bl
Externí odkaz:
https://doaj.org/article/b9dba9a5c93f4d56b563f3e09625703a
Autor:
Jordan Swiderski, Laura Kate Gadanec, Vasso Apostolopoulos, Graham J. Moore, Konstantinos Kelaidonis, John M. Matsoukas, Anthony Zulli
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 787 (2023)
Cardiovascular diseases (CVDs) are the main contributors to global morbidity and mortality. Major pathogenic phenotypes of CVDs include the development of endothelial dysfunction, oxidative stress, and hyper-inflammatory responses. These phenotypes h
Externí odkaz:
https://doaj.org/article/06b726c78186485ba573dccbd51f8787
Autor:
Graham J. Moore, Harry Ridgway, Konstantinos Kelaidonis, Christos T. Chasapis, Irene Ligielli, Thomas Mavromoustakos, Joanna Bojarska, John M. Matsoukas
Publikováno v:
Molecules, Vol 27, Iss 15, p 4854 (2022)
Angiotensin receptor blockers (ARBs) used in the treatment of hypertension and potentially in SARS-CoV-2 infection exhibit inverse agonist effects at angiotensin AR1 receptors, suggesting the receptor may have evolved to accommodate naturally occurri
Externí odkaz:
https://doaj.org/article/16c7f511d66a4c7f8ef39a135dff15e8
Autor:
Harry Ridgway, Christos T. Chasapis, Konstantinos Kelaidonis, Irene Ligielli, Graham J. Moore, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, Thomas Mavromoustakos, John M. Matsoukas
Publikováno v:
Viruses, Vol 14, Iss 5, p 1029 (2022)
SARS-CoV-2 is a global challenge due to its ability to mutate into variants that spread more rapidly than the wild-type virus. Because the molecular biology of this virus has been studied in such great detail, it represents an archetypal paradigm for
Externí odkaz:
https://doaj.org/article/693ec5b86d2b4c4ca9682b1260b5d669
Autor:
Graham J. Moore, Jose M. Pires, Konstantinos Kelaidonis, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, John M. Matsoukas
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 979 (2021)
Angiotensin II (Ang II) may contain a charge relay system (CRS) involving Tyr/His/carboxylate, which creates a tyrosinate anion for receptor activation. Energy calculations were carried out to determine the preferred geometry for the CRS in the prese
Externí odkaz:
https://doaj.org/article/3afc2b31bb9f4df79ed1ff00efb5862d
Autor:
Chasapis, Despoina P. Kiouri, Charalampos Ntallis, Konstantinos Kelaidonis, Massimiliano Peana, Sotirios Tsiodras, Thomas Mavromoustakos, Alessandro Giuliani, Harry Ridgway, Graham J. Moore, John M. Matsoukas, Christos T.
Publikováno v:
Proteomes; Volume 11; Issue 2; Pages: 21
The potential of targeting the Renin-Angiotensin-Aldosterone System (RAAS) as a treatment for the coronavirus disease 2019 (COVID-19) is currently under investigation. One way to combat this disease involves the repurposing of angiotensin receptor bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::4d0c4c24e862475298eb60ba8a308172
Autor:
Konstantinos Kelaidonis, Irene Ligielli, Spiros Letsios, Veroniki P. Vidali, Thomas Mavromoustakos, Niki Vassilaki, Graham J. Moore, Weronika Hoffmann, Katarzyna Węgrzyn, Harry Ridgway, Christos T. Chasapis, John M. Matsoukas
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8454
This study is an extension of current research into a novel class of synthetic antihypertensive drugs referred to as “bisartans”, which are bis-alkylated imidazole derivatives bearing two symmetric anionic biphenyltetrazoles. Research to date ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91d717bb4fe0c6530e30d3fb6a59379
https://doi.org/10.3390/ijms24098454
https://doi.org/10.3390/ijms24098454