Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Graham J. Hatch"'
Autor:
Graham J. Hatch, Simon Parks, Rachel Fell, Kathryn Gowan, Karen Gooch, Nathan Wiblin, Stuart Dowall, Robert J. Watson, Debbie Harris, Roger Hewson, Susan A. Fotheringham, Francisco J. Salguero, Yper Hall, Oliver Carnell, Victoria Graham, Simon Mizen
Publikováno v:
Viruses, Vol 13, Iss 2251, p 2251 (2021)
Viruses
Volume 13
Issue 11
Viruses
Volume 13
Issue 11
The global pandemic of coronavirus disease (COVID-19) caused by infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to an international thrust to study pathogenesis and evaluate interventions. Experimental infection of
Autor:
Julia A. Tree, Simon R. Bate, Julia Vipond, Graham Hall, Allen D. G. Roberts, Geoffrey Pearson, Emma Rayner, Simon G. P. Funnell, Graham J. Hatch
Publikováno v:
Journal of Applied Microbiology
Aims The goal of this study was to examine, for the first time, the virulence and pathogenicity of aerosolized Burkholderia pseudomallei, strain NCTC 13392, in BALB/c mice in order to develop an animal model for testing novel medical countermeasures
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:7687-7692
Left untreated, inhalation anthrax is usually fatal. Vegetative forms of Bacillus anthracis survive in blood and tissues during infection due to elaboration of a protective poly-γ- d -glutamic acid (PDGA) capsule that permits uncontrolled bacterial
Autor:
James D. Blanchard, Julia Vipond, Karleigh A. Hamblin, James Pitman, Stuart J. Armstrong, D. J. Atkinson, Graham Hall, Isobel H. Norville, Graham J. Hatch, Timothy P. Atkins, Emma Rayner, Kevin R. Bewley
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:5510-5518
Encapsulation of antibiotics may improve treatment of intracellular infections by prolonging antibiotic release and improving antibiotic uptake into cells. In this study, liposome-encapsulated ciprofloxacin for inhalation (CFI) was evaluated as a pos
Publikováno v:
Journal of Applied Microbiology. 111:350-359
Aims: We undertook a series of experiments to investigate factors that contribute to variation in Mycobacterium tuberculosis viability and infectivity, during experimental aerosolization, with an aim to optimize a strategy to enable a more reproducib
Autor:
Emma Rayner, Victoria A. Graham, Geoff Pearson, Julia Vipond, Graham Hall, Simon G. P. Funnell, Julia A. Tree, Kimberley Steeds, Irene Taylor, Allen D. G. Roberts, Kevin R. Bewley, Graham J. Hatch, Mike Dennis
To evaluate new vaccines when human efficacy studies are not possible, the FDA's “Animal Rule” requires well-characterized models of infection. Thus, in the present study, the early pathogenic events of monkeypox infection in nonhuman primates, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ecd2f37c53d377dd9e30dfa0d6553f
https://europepmc.org/articles/PMC4442344/
https://europepmc.org/articles/PMC4442344/
Autor:
Nigel P. Minton, Ann Williams, Simon O. Clark, Helen Shuttleworth, Graham J. Hatch, Emma Allen-Vercoe, Philip Marsh, Karen Blake, Joanna Bacon, Toby Hampshire, Julia Vipond, Richard Vipond, Karen E. Gooch
Publikováno v:
Vaccine. 24:6340-6350
Putative TB vaccine candidates were selected from lists of genes induced in response to in vivo-like stimuli, such as low oxygen and carbon starvation or growth in macrophages, and tested as plasmid DNA vaccines for their ability to protect against M
Autor:
Julia Vipond, Richard Vipond, Julia A. Tree, Philip Marsh, Else Marie Agger, Ann Williams, Simon O. Clark, Graham J. Hatch
Publikováno v:
Tuberculosis. 86:218-224
Summary A selection of previously identified protective Mycobacterium tuberculosis DNA vaccines were re-formulated as proteins and administered with a Th1-inducing adjuvant to help stimulate the relevant immune responses necessary for protection. All
Autor:
Nilu Goonetilleke, Andrzej Pawlowski, Kim A. Hatch, Graham J. Hatch, Peter Andersen, T. Mark Doherty, Ann Williams, Wilfried Dalemans, Helen McShane, Karen E. Gooch, Kris Huygen, Stefan H. E. Kaufmann, Karen Blake, Douglas B. Lowrie, Stewart T. Cole, Philip Marsh, Tanya Parish, Simon O. Clark, Alexander S. Pym, Joe Cohen, Gunilla Källenius, Priscille Brodin, Carlos Martin, Brigitte Gicquel, Kees L. M. C. Franken, Stefan B. Svenson, Yves Lobet, Debbie A. Smith, Peter Seiler, Graham Hall, Neil G. Stoker, Adrian V. S. Hill, Leander Grode, Tom H. M. Ottenhoff
Publikováno v:
Tuberculosis. 85:29-38
The TB Vaccine Cluster project funded by the EU Fifth Framework programme aims to provide novel vaccines against tuberculosis that are suitable for evaluation in humans. This paper describes the studies of the protective efficacy of vaccines in a gui
Autor:
Philip Marsh, Gunilla Källenius, Graham J. Hatch, Stefan B. Svenson, Ulf Schröder, Andrzej Pawlowski, Graham Hall, Melles Haile, Ann Williams, Beston Hamasur
Publikováno v:
Vaccine. 21:4081-4093
Lipoarabinomannan (LAM) is a major structural surface component of mycobacteria. Arabinomannan (AM) oligosaccharides derived from LAM of Mycobacterium tuberculosis H37Rv were isolated and covalently conjugated to tetanus toxoid (TT) or to short-term