Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Graham H. Thomas"'
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93680 (2014)
It is increasingly recognized that non-erythroid spectrins have roles remote from the plasma membrane, notably in endomembrane trafficking. The large spectrin isoform, βH, partners with Annexin B9 to modulate endosomal processing of internalized pro
Externí odkaz:
https://doaj.org/article/6b9fedd8f8b94556bcac036a59c3dd29
Autor:
Khurts Shilagardi, Eric Schiffhauer, Douglas N. Robinson, Tianzhi Luo, Dong-Hoon Lee, Shuo Li, Graham H. Thomas, Sungmin Son, Rui Duan, Elizabeth H. Chen, Daniel A. Fletcher, Ji Hoon Kim
Spectrin is a membrane skeletal protein best known for its structural role in maintaining cell shape and protecting cells from mechanical damage1-3. Here, we report that spectrin dynamically accumulates and dissolves at the fusogenic synapse, where a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d51a6ac22cf98cbe312084b1c9ea2a7
Autor:
Seungkyu Lee, Graham H. Thomas
Publikováno v:
Mechanisms of Development. 128:116-128
Epithelial polarity and morphogenesis require the careful coordination of signaling and cytoskeletal elements. In this paper, we describe multiple genetic interactions between the apical cytoskeletal protein β(H) and Rac1 signaling in Drosophila: ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e2b09417b5e662af04629f229140d9
https://doi.org/10.1016/j.mod.2010.11.004
https://doi.org/10.1016/j.mod.2010.11.004
Autor:
Elizabeth A. Klipfell, Janice A. Williams, Emmanuelle Médina, Graham H. Thomas, André Le Bivic, Daniela C. Zarnescu
Publikováno v:
The Journal of Cell Biology
The apical transmembrane protein Crumbs is necessary for both cell polarization and the assembly of the zonula adherens (ZA) in Drosophila epithelia. The apical spectrin-based membrane skeleton (SBMS) is a protein network that is essential for epithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8484a80a7caf55c26640ccae998680b
https://doi.org/10.1083/jcb.200203080
https://doi.org/10.1083/jcb.200203080
Autor:
David W. Speicher, Megan D. Radyk, Sandra L. Harper, Floyd J. Mattie, Stephanie E Crilly, Mansi R. Khanna, Graham H. Thomas, Katelyn J. Bakerink, Kristen C. Browder
Publikováno v:
The Journal of biological chemistry. 290(2)
The dominant paradigm for spectrin function is that (αβ)2-spectrin tetramers or higher order oligomers form membrane-associated two-dimensional networks in association with F-actin to reinforce the plasma membrane. Tetramerization is an essential e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ac57e1905eff9404a6adbaa6807d1a
https://pubmed.ncbi.nlm.nih.gov/25381248
https://pubmed.ncbi.nlm.nih.gov/25381248
Autor:
Graham H. Thomas
Publikováno v:
BioEssays. 23:152-160
It has long been speculated that spectrin, the actin crosslinking and molecular scaffold protein, is involved in the development of apicobasal polarity in epithelia. While spectrins can undoubtedly influence the protein content of specific membrane d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3204bc5b38f617ff8066f5a57687a52
https://doi.org/10.1002/1521-1878(200102)23:2<152::aid-bies1022>3.0.co
https://doi.org/10.1002/1521-1878(200102)23:2<152::aid-bies1022>3.0.co
Autor:
Daniela C. Zarnescu, Graham H. Thomas
Publikováno v:
The Journal of Cell Biology
Changes in cell shape and position drive morphogenesis in epithelia and depend on the polarized nature of its constituent cells. The spectrin-based membrane skeleton is thought to be a key player in the establishment and/or maintenance of cell shape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c036dadd02c3e09cb9299f3bb54c45
http://europepmc.org/articles/PMC2169487
http://europepmc.org/articles/PMC2169487
Autor:
Amy Londergan, Daniel P. Kiehart, Graham H. Thomas, Carol C. Korte, Mark A. Bales, Daniela C. Zarnescu, Amy E. Juedes
Publikováno v:
Development. 125:2125-2134
The spectrin membrane skeleton is a ubiquitous cytoskeletal structure with several cellular roles, including the maintenance of cell integrity, determination of cell shape and as a contributor to cell polarity. We have isolated mutations in the gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd7d8936c0d6a05a65065ec50b999c0
https://doi.org/10.1242/dev.125.11.2125
https://doi.org/10.1242/dev.125.11.2125
Autor:
M A Bales, Andrew G. Clark, Spencer V. Muse, Graham H. Thomas, Carol C. Korte, E C Newbern, Daniel P. Kiehart
Publikováno v:
Molecular Biology and Evolution. 14:1285-1295
Many structural, signaling, and adhesion molecules contain tandemly repeated amino acid motifs. The alpha-actinin/spectrin/dystrophin superfamily of F-actin-crosslinking proteins contains an array of triple alpha-helical motifs (spectrin repeats). We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dfcb690c1a6cc51ba7041ed6ef2fe8
https://doi.org/10.1093/oxfordjournals.molbev.a025738
https://doi.org/10.1093/oxfordjournals.molbev.a025738
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e93680 (2014)
PLoS ONE, Vol 9, Iss 4, p e93680 (2014)
It is increasingly recognized that non-erythroid spectrins have roles remote from the plasma membrane, notably in endomembrane trafficking. The large spectrin isoform, βH, partners with Annexin B9 to modulate endosomal processing of internalized pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3773c0295bb408bf71943cc3684604d4
https://pubmed.ncbi.nlm.nih.gov/24705398
https://pubmed.ncbi.nlm.nih.gov/24705398