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of 2
pro vyhledávání: '"Graham H. Oakes"'
Autor:
Nicholas Greeves, Steven P McLachlan, Mark Purdie, Graham H Oakes, Jamie F. Bickley, Wai-Man Lee
Publikováno v:
Tetrahedron Letters. 44:9035-9038
A stereoselective potassium hydride/18-crown-6 mediated double tandem etherification-[2,3]-Wittig-anionic oxy-Cope rearrangement was used to prepare a δ,e-unsaturated aldehyde with syn stereochemistry. Wittig olefination, dihydroxylation and stereos
Autor:
Laurence C. Powling, David S. Ennis, David Lathbury, Mark A. Armitage, Paul D. Blackler, Nigel Hussain, Graham H. Oakes, Noah O'Connor, David O. Morgan, Richard K. Bellingham, and Stephen C. Passey, Karl W. Ace
Publikováno v:
Organic Process Research & Development. 5:479-490
A literature route to 1-(2-{4-[(E)-1-(4-iodophenyl)-2-phenyl-but-1-enyl]phenoxy}ethyl)pyrrolidine (idoxifene) has been modified to tackle various scale-up issues and provide initial supplies. A new highly efficient, robust, and stereoselective manufa