Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Graham H. Allcock"'
Publikováno v:
Journal of Leukocyte Biology. 69:98-104
The effects of the natural and synthetic ligands for the melanocortin receptor type 3 (MC3-R) have been evaluated in a murine model of experimental gout. Systemic treatment of mice with γ2-melanocyte-stimulating hormone (γ2-MSH) and the synthetic a
Publikováno v:
American Journal of Physiology-Renal Physiology. 278:F279-F286
Experiments were designed to elucidate the role of endothelin B receptors (ETB) on arterial pressure and renal function in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Male Sprague-Dawley rats underwent uninephrectomy and were treated w
Publikováno v:
Europe PubMed Central
In addition to its hemodynamic effects, nitric oxide (NO) may play a role in the renal tubular handling of sodium. Experiments were conducted to determine possible changes in renal nitric oxide synthase-3 (NOS3) expression in rats treated with deoxyc
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 275:R245-R252
Endothelin (ET)-1 has potent renal and systemic vasoconstrictor properties, and thus we investigated whether ET-1 plays a role in increasing blood pressure and decreasing renal function in DOCA-salt hypertension. After a right nephrectomy, rats had D
Autor:
Timothy D. Warner, Graham H. Allcock
Publikováno v:
Life Sciences. 60:PL271-PL276
It is believed that changes in the production and release of endothelin-1 (ET-1) are mediated over prolonged periods, and, therefore, that it is unlikely that ET-1 mediates rapid responses within the circulation. Here we show that ET-1 is involved in
Publikováno v:
British Journal of Pharmacology. 116:2482-2486
1. Endothelin-1 (ET-1) produces vasoconstriction, via activation of ETA and ETB receptors on vascular smooth muscle, and vasodilatation via ETB receptors on endothelial cells. Here we have used the ETA receptor-selective antagonist, BQ-123, the ETB r
Publikováno v:
British Journal of Pharmacology. 110:777-782
1. We have compared the receptors mediating the contractions of rings of rat thoracic aorta or rabbit pulmonary artery and rat stomach strips in response to the endothelin/sarafotoxin (ET/SX) family of peptides and to those mediating endothelium-depe
Publikováno v:
British Journal of Pharmacology. 110:783-789
1. To characterize the receptors mediating the effects of the endothelin/sarafotoxin family of peptides on the responses to electrical stimulation of the rat vas deferens (RVD) and guinea-pig ileum (GPI) we have used endothelin-1 (ET-1), ET-3, sarafo
Publikováno v:
Journal of Cardiovascular Pharmacology. 22:S117-S120
Endothelin-1 (ET-1), endothelin-3 (ET-3), sarafotoxin 6b (SX6b), and sarafotoxin 6C (SX6c) were used as agonists, and BQ-123 (ETA-selective) and PD 142893 (ET receptor-nonselective) were used as antagonists to characterize the receptors mediating the
Autor:
Graham H. Allcock, Timothy D. Warner
Publikováno v:
Journal of Cardiovascular Pharmacology. 26:S177-179