Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Graham G. Inglis"'
Autor:
Vijay Chudasama, Natalia Smoktunowicz, Graham G. Inglis, Eifion Robinson, Stephen Caddick, Emily Knight, Rachel C. Chambers
Publikováno v:
Organic & Biomolecular Chemistry. 14:3198-3201
The discontinuation of PAR-1 antagonist RWJ-58259 beyond use as a biological probe is most likely due to it's short half-life in vivo. However, retention of significant in vivo activity beyond the point where most of the RWJ-58259 had been consumed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af35dd5509eef3e9ac97676bda2beb7b
https://doi.org/10.1039/c6ob00332j
https://doi.org/10.1039/c6ob00332j
Autor:
Abil E. Aliev, Natalia Smoktunowicz, Emily Knight, Eifion Robinson, Rachel C. Chambers, Stephen Caddick, Graham G. Inglis, Vijay Chudasama
Publikováno v:
Organicbiomolecular chemistry. 14(12)
Vorapaxar is a first-in-class PAR-1 antagonistic drug based on the ent-himbacine scaffold. Detailed in this article are enantioselective and racemic routes to various novel vorapaxar analogues. Biological testing revealed these compounds to have mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658b3119210982982a59b7f6fdf0eb07
https://pubmed.ncbi.nlm.nih.gov/26932831
https://pubmed.ncbi.nlm.nih.gov/26932831
Publikováno v:
Organic Letters; Apr2011, Vol. 13 Issue 7, p1686-1689, 4p
Autor:
Bush JT; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Pogany P; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Pickett SD; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Barker M; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Baxter A; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Campos S; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Cooper AWJ; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Hirst D; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Inglis G; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Nadin A; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Patel VK; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Poole D; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Pritchard J; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Washio Y; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., White G; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Green DVS; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2020 Oct 22; Vol. 63 (20), pp. 11964-11971. Date of Electronic Publication: 2020 Oct 12.
Autor:
Hobbs H; GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage SG1 2NY , U.K., Bravi G; GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage SG1 2NY , U.K., Campbell I; GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage SG1 2NY , U.K., Convery M; GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage SG1 2NY , U.K., Davies H; GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage SG1 2NY , U.K., Inglis G; GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage SG1 2NY , U.K., Pal S; GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage SG1 2NY , U.K., Peace S; GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage SG1 2NY , U.K., Redmond J; GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage SG1 2NY , U.K., Summers D; GlaxoSmithKline R&D , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2019 Aug 08; Vol. 62 (15), pp. 6972-6984. Date of Electronic Publication: 2019 Jul 23.
Autor:
Barton N; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Convery M; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Cooper AWJ; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Down K; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Hamblin JN; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Inglis G; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Peace S; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Rowedder J; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Rowland P; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Taylor JA; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Wellaway N; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2018 Dec 27; Vol. 61 (24), pp. 11061-11073. Date of Electronic Publication: 2018 Dec 21.
Autor:
Amour A, Barton N, Cooper AW, Inglis G, Jamieson C, Luscombe CN, Morrell J, Peace S, Perez D, Rowland P, Tame CJ, Uddin S, Vitulli G, Wellaway N
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2016 Oct 27; Vol. 59 (20), pp. 9574. Date of Electronic Publication: 2016 Oct 11.
Autor:
Amour A; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K., Barton N; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K., Cooper AW; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K., Inglis G; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K., Jamieson C; Department of Pure and Applied Chemistry, University of Strathclyde , 295 Cathedral Street, Glasgow G1 1XL, U.K., Luscombe CN; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K., Morrell J; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K., Peace S; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K., Perez D; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K., Rowland P; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K., Tame CJ; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K., Uddin S; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K., Vitulli G; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K., Wellaway N; GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2016 Aug 11; Vol. 59 (15), pp. 7239-51. Date of Electronic Publication: 2016 Jul 27.