Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Graham G Walmsley"'
Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury.
Autor:
Andrew S Zimmermann, Shane D Morrison, Michael S Hu, Shuli Li, Allison Nauta, Michael Sorkin, Nathaniel P Meyer, Graham G Walmsley, Zeshaan N Maan, Denise A Chan, Geoffrey C Gurtner, Amato J Giaccia, Michael T Longaker
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93373 (2014)
INTRODUCTION:Hypoxia-inducible factor (HIF)-1α, part of the heterodimeric transcription factor that mediates the cellular response to hypoxia, is critical for the expression of multiple angiogenic growth factors, cell motility, and the recruitment o
Externí odkaz:
https://doaj.org/article/66c1a0096a934e2fb2572ea89d7a7aca
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e945 (2007)
The Wnt signaling system plays key roles in development, regulation of stem cell self-renewal and differentiation, cell polarity, morphogenesis and cancer. Given the multifaceted roles of Wnt signaling in these processes, its transcriptional effects
Externí odkaz:
https://doaj.org/article/e6b7ab9c1feb45df87b5d8169f205144
Autor:
Zeshaan N. Maan, Dominik Duscher, Janos A. Barrera, Victor W. Wong, Sacha M.L. Khong, Ferdinando Giacco, Michael T. Longaker, Michael Brownlee, Michael Januszyk, Michael S. Hu, Sun Hyung Kwon, Graham G. Walmsley, Lauren H. Fischer, Geoffrey C. Gurtner, Alexander J. Whittam
Publikováno v:
Transl Res
In diabetes, stromal cell-derived factor-1 (SDF-1) expression and progenitor cell recruitment are reduced. Dipeptidyl peptidase-4 (DPP-4) inhibits SDF-1 expression and progenitor cell recruitment. Here we examined the impact of the DPP-4 inhibitor, M
Autor:
Michael T. Longaker, Ruth Tevlin, Anna Luan, Wan Xing Hong, Michael Januszyk, Hermann P. Lorenz, Graham G. Walmsley, Mimi R. Borrelli, Geoffrey C. Gurtner, Michael S. Hu, Samir Malhotra
Publikováno v:
Advances in Wound Care. 7:1-10
Objective: Fetuses early in gestation heal skin wounds without forming scars. The biological mechanisms behind this process are largely unknown. Fibroblasts, however, are cells known to be intimately involved in wound healing and scar formation. We e
Autor:
Sacha M.L. Khong, Michael T. Longaker, Yixiao Dong, Graham G. Walmsley, Geoffrey C. Gurtner, Alexander J. Whittam, Michael S. Hu, Dominik Duscher, Zeshaan N. Maan, Michael Januszyk
Publikováno v:
Plastic and Reconstructive Surgery. 139:695e-706e
Background:A hallmark of diabetes mellitus is the breakdown of almost every reparative process in the human body, leading to critical impairments of wound healing. Stabilization and activity of the transcription factor hypoxia-inducible factor (HIF)-
Autor:
Eun Young Seo, Elizabeth R. Zielins, Charles Chan, Kevin J. Paik, Christopher Duldulao, Michael T. Chung, Michael T. Longaker, Stephanie Vistnes, Adrian McArdle, Ruth Tevlin, Graham G. Walmsley, David Atashroo, Derrick C. Wan, Elizabeth A. Brett
Publikováno v:
Plast Reconstr Surg
BACKGROUND: The authors have developed a novel protocol for isolating adipose-derived stem cells from human lipoaspirate. In this study, they compare their new method to a previously published standard protocol. METHODS: Human adipose-derived stem ce
Autor:
Andrew S. Lee, Graham G. Walmsley, John Flacco, Michael S. Hu, Michael T. Longaker, Elizabeth R. Zielins, Tripp Leavitt, Derrick C. Wan, Ryan C. Ransom
Publikováno v:
Stem Cell Reviews and Reports. 12:524-529
Bone has the capacity to regenerate and repair itself. However, this capacity may be impaired or lost depending on the size of the defect or the presence of certain disease states. In this review, we discuss the key principles underlying bone healing
Autor:
Michael S. Pollhammer, David Atashroo, Alexander J. Whittam, Zeshaan N. Maan, Hans-Günther Machens, Elizabeth R. Zielins, Michael S. Hu, Manfred Schmidt, Georg M. Huemer, Anna Luan, Janos A. Barrera, Graham G. Walmsley, Dominik Duscher, Derrick C. Wan, Sacha M.L. Khong, Arndt F. Schilling, Geoffrey C. Gurtner, Michael T. Longaker, Elizabeth A. Brett
Publikováno v:
Stem Cells Translational Medicine
The regenerative abilities of adipose-derived mesenchymal stem cells (ASCs) harvested via a third-generation ultrasound-assisted liposuction (UAL) device versus ASCs obtained via standard suction-assisted lipoaspiration were evaluated. ASC yield and
Autor:
Michael T. Longaker, Ankit Salhotra, Heather E. desJardins-Park, Howard Y. Chang, Mimi R. Borrelli, Ethan Z. Shen, Clement D. Marshall, Tripp Leavitt, Bryan Duoto, Ulrike M. Litzenburger, Geoffrey C. Gurtner, Hermann P. Lorenz, Deshka S. Foster, Zeshaan N. Maan, Sandeep Adem, Julia T. Garcia, Shamik Mascharak, Leandra A. Barnes, Michelle Griffin, Graham G. Walmsley, Yuning Wei, Elizabeth R. Zielins, Michael S. Hu, Alessandra L. Moore, Michael Januszyk, Charles Chan, Ryan C. Ransom, Abra H. Shen, Derrick C. Wan
Publikováno v:
Cell reports
SUMMARY Fibroblast heterogeneity has been shown within the unwounded mouse dorsal dermis, with fibroblast subpopulations being identified according to anatomical location and embryonic lineage. Using lineage tracing, we demonstrate that paired relate
Autor:
Ruth Tevlin, Derrick C. Wan, Michael Januszyk, H. Peter Lorenz, Zeshaan N. Maan, Graham G. Walmsley, Anna Luan, Wan Xing Hong, Geoffrey C. Gurtner, Shawn Moshrefi, Michael S. Hu, Michael T. Longaker
Objective: In early gestation, fetal wounds heal without fibrosis in a process resembling regeneration. Elucidating this remarkable mechanism can result in tremendous benefits to prevent scarring. Fetal mouse cutaneous wounds before embryonic day (E)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3077708c957211341c5a90b6d522626e
https://europepmc.org/articles/PMC6080120/
https://europepmc.org/articles/PMC6080120/