Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Graham F. Smith"'
Autor:
Joerg Schlingemann, Michael J. Burns, David J. Ponting, Carolina Martins Avila, Naiffer E. Romero, Mrunal A. Jaywant, Graham F. Smith, Ian W. Ashworth, Stephanie Simon, Christoph Saal, Andrzej Wilk
Publikováno v:
Journal of Pharmaceutical Sciences. 112:1287-1304
This article reports the outcome of an in silico analysis of more than 12,000 small molecule drugs and drug impurities, identifying the nitrosatable structures, assessing their potential to form nitrosamines under relevant conditions and the challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da45a3df822dccf8629262f20bfad6a7
https://doi.org/10.1016/j.xphs.2022.11.013
https://doi.org/10.1016/j.xphs.2022.11.013
Autor:
Olga Obrezanova, Anton Martinsson, Tom Whitehead, Samar Mahmoud, Andreas Bender, Filip Miljković, Piotr Grabowski, Ben Irwin, Ioana Oprisiu, Gareth Conduit, Matthew Segall, Graham F. Smith, Beth Williamson, Susanne Winiwarter, Nigel Greene
Publikováno v:
Molecular Pharmaceutics. 19:1488-1504
Animal pharmacokinetic (PK) data as well as human and animal in vitro systems are utilized in drug discovery to define the rate and route of drug elimination. Accurate prediction and mechanistic understanding of drug clearance and disposition in anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9bd2b4cfbc81205355cb3ed27f5a7e
https://doi.org/10.1021/acs.molpharmaceut.2c00027
https://doi.org/10.1021/acs.molpharmaceut.2c00027
Autor:
Rodrigo Aguilar, Kerrie B. Spencer, Barry Kesner, Noreen F. Rizvi, Maulik D. Badmalia, Tyler Mrozowich, Jonathan D. Mortison, Carlos Rivera, Graham F. Smith, Julja Burchard, Peter J. Dandliker, Trushar R. Patel, Elliott B. Nickbarg, Jeannie T. Lee
Publikováno v:
Nature. 604:160-166
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e8a3cf190dc85ff39d8166a46f4b293
https://doi.org/10.1038/s41586-022-04537-z
https://doi.org/10.1038/s41586-022-04537-z
Autor:
Helen L. Lightfoot, Graham F. Smith
Publikováno v:
British Journal of Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcfafd00e0427819b66181c62055d893
https://doi.org/10.1111/bph.16027
https://doi.org/10.1111/bph.16027
Autor:
Hongbin Yang, Olga Obrezanova, Amy Pointon, Will Stebbeds, Jo Francis, Kylie A. Beattie, Peter Clements, James S. Harvey, Graham F. Smith, Andreas Bender
Publikováno v:
Toxicology and applied pharmacology. 459
Functional changes to cardiomyocytes are undesirable during drug discovery and identifying the inotropic effects of compounds is hence necessary to decrease the risk of cardiovascular adverse effects in the clinic. Recently, approaches leveraging cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0701a3e2e313a100eb27016eaf86803
https://pubmed.ncbi.nlm.nih.gov/36502871
https://pubmed.ncbi.nlm.nih.gov/36502871
Autor:
Peter S.R. Wright, Graham F. Smith, Katharine A. Briggs, Robert Thomas, Gareth Maglennon, Paulius Mikulskis, Melissa Chapman, Nigel Greene, Benjamin U. Phillips, Andreas Bender
Publikováno v:
Regulatory Toxicology and Pharmacology. 138:105309
Virtual Control Groups (VCGs) based on Historical Control Data (HCD) in preclinical toxicity testing have the potential to reduce animal usage. As a case study we retrospectively analyzed the impact of replacing Concurrent Control Groups (CCGs) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6a8d0bc1f1938928ac682adf89ef87
https://doi.org/10.1016/j.yrtph.2022.105309
https://doi.org/10.1016/j.yrtph.2022.105309
Autor:
Peter S.R. Wright, Katharine A. Briggs, Robert Thomas, Graham F. Smith, Gareth Maglennon, Paulius Mikulskis, Melissa Chapman, Nigel Greene, Benjamin U. Phillips, Andreas Bender
Publikováno v:
Regulatory Toxicology and Pharmacology. 138:105308
Preclinical inter-species concordance can increase the predictivity of observations to the clinic, potentially reducing drug attrition caused by unforeseen adverse events. We quantified inter-species concordance of histopathological findings and targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9287b4a9f7dd7001a658be97ded020
https://doi.org/10.1016/j.yrtph.2022.105308
https://doi.org/10.1016/j.yrtph.2022.105308
Autor:
Graham F, Smith
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2390
The use of artificial intelligence methods in drug safety began in the early 2000s with applications such as predicting bacterial mutagenicity and hERG inhibition. The field has been endlessly expanding ever since and the models have become more comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e017e2b9862a77e371677f02b33506b
https://pubmed.ncbi.nlm.nih.gov/34731484
https://pubmed.ncbi.nlm.nih.gov/34731484
Autor:
William, McCoull, Scott, Boyd, Martin R, Brown, Muireann, Coen, Olga, Collingwood, Nichola L, Davies, Ann, Doherty, Gary, Fairley, Kristin, Goldberg, Elizabeth, Hardaker, Guang, He, Edward J, Hennessy, Philip, Hopcroft, George, Hodgson, Anne, Jackson, Xiefeng, Jiang, Ankur, Karmokar, Anne-Laure, Lainé, Nicola, Lindsay, Yumeng, Mao, Roshini, Markandu, Lindsay, McMurray, Neville, McLean, Lorraine, Mooney, Helen, Musgrove, J Willem M, Nissink, Alexander, Pflug, Venkatesh Pilla, Reddy, Philip B, Rawlins, Emma, Rivers, Marianne, Schimpl, Graham F, Smith, Sharon, Tentarelli, Jon, Travers, Robert I, Troup, Josephine, Walton, Cheng, Wang, Stephen, Wilkinson, Beth, Williamson, Jon, Winter-Holt, Dejian, Yang, Yuting, Zheng, Qianxiu, Zhu, Paul D, Smith
Publikováno v:
Journal of medicinal chemistry. 64(18)
Inhibition of Mer and Axl kinases has been implicated as a potential way to improve the efficacy of current immuno-oncology therapeutics by restoring the innate immune response in the tumor microenvironment. Highly selective dual Mer/Axl kinase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ae60041f0f2dfe86225bfbc9ef0aea3
https://pubmed.ncbi.nlm.nih.gov/34478292
https://pubmed.ncbi.nlm.nih.gov/34478292
Autor:
Hongbin Yang, Will Stebbeds, Jo Francis, Amy Pointon, Olga Obrezanova, Kylie A. Beattie, Peter Clements, James S. Harvey, Graham F. Smith, Andreas Bender
Publikováno v:
Stem cell reports. 17(3)
Human induced pluripotent stem cell-derived cardiomyocytes have been established to detect dynamic calcium transients by fast kinetic fluorescence assays that provide insights into specific aspects of clinical cardiac activity. However, the precise d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c276bf1246ef0bfb4fef52fd4c017e63
https://pubmed.ncbi.nlm.nih.gov/35148844
https://pubmed.ncbi.nlm.nih.gov/35148844