Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Graham Dellaire"'
Autor:
Michael McPhee, Jonghwa Lee, Jayme Salsman, Marinella Pinelli, Francesca Di Cara, Kirill Rosen, Graham Dellaire, Neale D. Ridgway
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 5, Pp 100540- (2024)
Intestinal epithelial cells convert excess fatty acids into triglyceride (TAG) for storage in cytoplasmic lipid droplets and secretion in chylomicrons. Nuclear lipid droplets (nLDs) are present in intestinal cells but their origin and relationship to
Externí odkaz:
https://doaj.org/article/7c3632dc14df4cafbcfc4d155a46f03c
Autor:
Tharindu L. Suraweera, J. P. Jose Merlin, Graham Dellaire, Zhaolin Xu, H. P. Vasantha Rupasinghe
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3676 (2023)
Cancer is one of the leading causes of death worldwide. Chemotherapy and radiation therapy are currently providing the basis for cancer therapies, although both are associated with significant side effects. Thus, cancer prevention through dietary mod
Externí odkaz:
https://doaj.org/article/0ca1777103a640f98dfa6cad13e39332
Autor:
Michael J. McPhee, Jayme Salsman, Jason Foster, Jordan Thompson, Sabateeshan Mathavarajah, Graham Dellaire, Neale D. Ridgway
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The nucleus harbours numerous protein subdomains and condensates that regulate chromatin organization, gene expression and genomic stress. A novel nuclear subdomain that is formed following exposure of cells to excess fatty acids is the nuclear lipid
Externí odkaz:
https://doaj.org/article/8bce2bba10a94b29ac182e66f19d8df8
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Pre-mRNA processing factor 4 kinase (PRP4K, also known as PRPF4B) is an essential kinase first identified in the fission yeast Schizosaccharomyces pombe that is evolutionarily conserved from amoebae to animals. During spliceosomal assembly, PRP4K int
Externí odkaz:
https://doaj.org/article/f6c8d57b9799413d9bb7287716e4cb1d
Autor:
J. P. Jose Merlin, Sabateeshan Mathavarajah, Graham Dellaire, Kieran P. J. Murphy, H. P. Vasantha Rupasinghe
Publikováno v:
Antioxidants, Vol 11, Iss 7, p 1407 (2022)
Antioxidants can be used as radioprotectants to reduce DNA damage due to exposure to radiation that could result in malignancies, including lung cancer. Mortality rates are consistently higher in lung cancer, which is usually diagnosed at later stage
Externí odkaz:
https://doaj.org/article/8ad01d738d2d49c69af987f1610d4c48
Autor:
Vinothkumar Rajan, Nicole Melong, Wing Hing Wong, Benjamin King, R. Spencer Tong, Nithin Mahajan, Daniel Gaston, Troy Lund, David Rittenberg, Graham Dellaire, Clinton J.V. Campbell, Todd Druley, Jason N. Berman
Publikováno v:
Haematologica, Vol 105, Iss 10 (2019)
Xenograft models are invaluable tools in establishing the current paradigms of hematopoiesis and leukemogenesis. The zebrafish has emerged as a robust alternative xenograft model but, like mice, lack specific cytokines that mimic the microenvironment
Externí odkaz:
https://doaj.org/article/732605c4586348e6ac1df48e0a742dd0
Publikováno v:
Haematologica, Vol 105, Iss 10 (2019)
GFI1B-related thrombocytopenia (GFI1B-RT) is a rare bleeding disorder mainly caused by the presence of truncated GFI1B proteins with dominant-negative properties. The disease is characterized by low platelet counts, the presence of abnormal platelets
Externí odkaz:
https://doaj.org/article/2d9af480dbf7402cbeeeb9d468fdbe65
Autor:
Anaïs Darracq, Helen Pak, Vincent Bourgoin, Farah Zmiri, Graham Dellaire, El Bachir Affar, Eric Milot
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008463 (2019)
Nucleophosmin (NPM1) is frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the nucleus, but the recurrent NPMc+ mutation, which creates a nuclear export signal, is charact
Externí odkaz:
https://doaj.org/article/f994d6816a354d76ae7c455bbb3ae1c1
Autor:
Charles Vadnais, Riyan Chen, Jennifer Fraszczak, Zhenbao Yu, Jonathan Boulais, Jordan Pinder, Daria Frank, Cyrus Khandanpour, Josée Hébert, Graham Dellaire, Jean-François Côté, Stéphane Richard, Alexandre Orthwein, Elliot Drobetsky, Tarik Möröy
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The transcription factor GFI1 mediates the DNA damage response (DDR) of T cells through a yet unknown mechanism. Here the authors show that GFI1 can adopt non-transcriptional roles during DDR, enabling PRMT1 to bind and methylate the DNA repair prote
Externí odkaz:
https://doaj.org/article/84219a0ff4704d3586e8769eac7e762a
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1665 (2021)
Lung cancer has the highest mortality rate worldwide and is often diagnosed at late stages, requiring genotoxic chemotherapy with significant side effects. Cancer prevention has become a major focus, including the use of dietary and supplemental anti
Externí odkaz:
https://doaj.org/article/3a3d25f1ca474dedb25289f0a1facaf0