Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Graham D. Pavitt"'
Autor:
Ebelechukwu C. Nwokoye, Eiman AlNaseem, Robert A. Crawford, Lydia M. Castelli, Martin D. Jennings, Christopher J. Kershaw, Graham D. Pavitt
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract By interacting with the mRNA 5′ cap, the translation initiation factor eIF4E plays a critical role in selecting mRNAs for protein synthesis in eukaryotic cells. Caf20 is a member of the family of proteins found across eukaryotes termed 4E-
Externí odkaz:
https://doaj.org/article/a170f8d568954ea3bc06d0d1845d3a9b
Autor:
Víctor Faundes, Martin D. Jennings, Siobhan Crilly, Sarah Legraie, Sarah E. Withers, Sara Cuvertino, Sally J. Davies, Andrew G. L. Douglas, Andrew E. Fry, Victoria Harrison, Jeanne Amiel, Daphné Lehalle, William G. Newman, Patricia Newkirk, Judith Ranells, Miranda Splitt, Laura A. Cross, Carol J. Saunders, Bonnie R. Sullivan, Jorge L. Granadillo, Christopher T. Gordon, Paul R. Kasher, Graham D. Pavitt, Siddharth Banka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
eIF5A is critical for protein synthesis but has not yet been associated with congenital human disease. Here, the authors show that EIF5A variants cause a Mendelian disorder via reduced eIF5A-ribosome interactions and this phenotype is partially corre
Externí odkaz:
https://doaj.org/article/e484f6bf742d4dfaa468f76258820800
Publikováno v:
eLife, Vol 11 (2022)
Regulation of translation is a fundamental facet of the cellular response to rapidly changing external conditions. Specific RNA-binding proteins (RBPs) co-ordinate the translational regulation of distinct mRNA cohorts during stress. To identify RBPs
Externí odkaz:
https://doaj.org/article/bdce106b34294b28b159b3d0baab47c3
Autor:
Christopher J. Kershaw, Martin D. Jennings, Francesco Cortopassi, Margherita Guaita, Hawra Al-Ghafli, Graham D. Pavitt
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103454- (2021)
Summary: eIF2B is the guanine nucleotide exchange factor (GEF) required for cytoplasmic protein synthesis initiation in eukaryotes and its regulation within the integrated stress response (ISR). It activates its partner factor eIF2, thereby promoting
Externí odkaz:
https://doaj.org/article/63576347261d43b39ec105640f9c4851
Autor:
Tomas Adomavicius, Margherita Guaita, Yu Zhou, Martin D. Jennings, Zakia Latif, Alan M. Roseman, Graham D. Pavitt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
During the integrated stress response, translation is modulated through the phosphorylation of translation initiation factor eIF2 and the formation of a complex with eIF2B. Here the authors present structures of the eIF2:eIF2B complex with and withou
Externí odkaz:
https://doaj.org/article/b178b1da56a2498cb1e4d2d9ec16bc26
Autor:
Joseph L. Costello, Christopher J. Kershaw, Lydia M. Castelli, David Talavera, William Rowe, Paul F. G. Sims, Mark P. Ashe, Christopher M. Grant, Simon J. Hubbard, Graham D. Pavitt
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-18 (2017)
Abstract Background Translation factors eIF4E and eIF4G form eIF4F, which interacts with the messenger RNA (mRNA) 5′ cap to promote ribosome recruitment and translation initiation. Variations in the association of eIF4F with individual mRNAs likely
Externí odkaz:
https://doaj.org/article/e9827a4beac84ea28a009ec11d03c0fc
Autor:
Martin D Jennings, Priya Srivastava, Christopher J Kershaw, David Talavera, Christopher M Grant, Graham D Pavitt
Publikováno v:
Nucleic Acids Research.
In response to oxidative stress cells reprogram gene expression to enhance levels of antioxidant enzymes and promote survival. In Saccharomyces cerevisiae the polysome-interacting La-related proteins (LARPs) Slf1 and Sro9 aid adaptation of protein sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3af404b8973844e50e1fb43a1e6aaa2c
https://doi.org/10.1093/nar/gkad272
https://doi.org/10.1093/nar/gkad272
Publikováno v:
eLife, Vol 6 (2017)
Phosphorylation of eIF2α controls translation initiation by restricting the levels of active eIF2-GTP/Met-tRNAi ternary complexes (TC). This modulates the expression of all eukaryotic mRNAs and contributes to the cellular integrated stress response.
Externí odkaz:
https://doaj.org/article/75f8611e47d04d95b6a8f582950959d1
Autor:
Martin D, Jennings, Graham D, Pavitt
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2428
The translation initiation factor eIF2 is critical for protein synthesis initiation, and its regulation is central to the integrated stress response (ISR). eIF2 is a G protein, and the activity is regulated by its GDP or GTP-binding status, such that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c0c7316b3d091c9527bbe7ce2fcfd05
https://pubmed.ncbi.nlm.nih.gov/35171475
https://pubmed.ncbi.nlm.nih.gov/35171475