Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Graham D Smith"'
Autor:
Marieke Lamers, Grant Wishart, Karen Barnes, Graham D. Smith, Ivan Angulo-Herrera, Sarah L. Martin, Rebecca E. Jarvis, Wesley Blackaby, Philip Leonard, Ovadia Lazari, Leticia Toledo-Sherman, David F. Fischer, Maria Eznarriaga, Simon J. Dowler, George McAllister, Rhea van de Bospoort, Dawn Yates, Annelieke Strijbosch, Helen C. Cox, Jennifer R. Bate, Esmieu William R K, Amanda Van de Poël, Roger Cachope, Sung-Wook Jang, Perla Breccia, Celia Dominguez, Mark Rose, Kim L. Matthews, Huw D. Vater, Stephen D. Penrose, Ignacio Munoz-Sanjuan
Publikováno v:
Journal of medicinal chemistry. 62(6)
Genetic and pharmacological evidence indicates that the reduction of ataxia telangiectasia-mutated (ATM) kinase activity can ameliorate mutant huntingtin (mHTT) toxicity in cellular and animal models of Huntington's disease (HD), suggesting that sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a89407c2d2edecea9555cc23f334e43
https://pubmed.ncbi.nlm.nih.gov/30840447
https://pubmed.ncbi.nlm.nih.gov/30840447
Autor:
Graham D Smith, Elaine Wan, Anita Holdcroft, Preethi Gopinath, Paul Facer, C. Bountra, Praveen Anand, John B. Davis
Publikováno v:
BMC Women's Health
BMC Women's Health, Vol 5, Iss 1, p 2 (2005)
BMC Women's Health, Vol 5, Iss 1, p 2 (2005)
Background Breast pain and tenderness affects 70% of women at some time. These symptoms have been attributed to stretching of the nerves with increase in breast size, but tissue mechanisms are poorly understood. Methods Eighteen patients (n = 12 brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceeda074ba9ae8a691ac43573d723c89
https://doi.org/10.1186/1472-6874-5-2
https://doi.org/10.1186/1472-6874-5-2
Publikováno v:
Biophysical Journal. 99:790-797
There is evidence that polycystin-2 (TRPP2) interacts with two other members of the transient receptor potential (TRP) family, TRPC1 and TRPV4. We have previously shown that TRPP2 forms a heteromeric complex with TRPC1, with a 2:2 stoichiometry and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bac3db1ae441b71067ed2716753cce4
https://doi.org/10.1016/j.bpj.2010.05.012
https://doi.org/10.1016/j.bpj.2010.05.012
Autor:
Alison I. Muir, William J. Coates, Adrian Hall, Stephen L. Garland, Neville Hubert Nicholson, Graham D Smith, Mark Wigglesworth, Shahzad Sharooq Rahman, Philip G. Szekeres, Berthold Wroblowski, Jag Paul Heer
Publikováno v:
Journal of Medicinal Chemistry. 52:818-825
The novel 7-transmembrane receptor MrgX1 is located predominantly in the dorsal root ganglion and has consequently been implicated in the perception of pain. Here we describe the discovery and optimization of a small molecule agonist and initial dock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9be92b3706555ea9dc7c317d831fed
https://doi.org/10.1021/jm800962k
https://doi.org/10.1021/jm800962k
Autor:
Kim Winborn, Sarah C. Lappin, James S. Wright, Vicky Holland, Martin J. Gunthorpe, Harshad Kantilal Rami, Andrew D. Randall, Sandra Arpino, Graham D Smith, Julie Egerton, Stephen J. Brough, Mervyn Thompson, Jeffrey C. Jerman, Sara Luis Hannan, Darren Smart, John B. Davis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:1183-1192
Vanilloid receptor-1 (TRPV1) is a nonselective cation channel, predominantly expressed by sensory neurons, which plays a key role in the detection of noxious painful stimuli such as capsaicin, acid, and heat. TRPV1 antagonists may represent novel the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519bdcb9b1541b2a29cae2ecf14a8d24
https://doi.org/10.1124/jpet.106.116657
https://doi.org/10.1124/jpet.106.116657
Autor:
James Davies, David G. Lambert, Davina E. Owen, Patricia M.W. Lam, Graham D Smith, Atticus H. Hainsworth
Publikováno v:
Journal of Neurochemistry. 102:801-811
The transient receptor potential (TRP) vanilloid receptor subtype 1 (TRPV1) is a ligand-gated, Ca(2+)-permeable ion channel in the TRP superfamily of channels. We report the establishment of the first neuronal model expressing recombinant human TRPV1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae8e55607b40fffa2804b03739a1682e
https://doi.org/10.1111/j.1471-4159.2007.04569.x
https://doi.org/10.1111/j.1471-4159.2007.04569.x
Autor:
S. Nasir, Angela Worby, Catherine H. Gill, Harshad Kantilal Rami, Wyman Paul Adrian, Jeffrey C. Jerman, Andrew D. Randall, John B. Davis, Mervyn Thompson, Darren Smart, Julie Egerton, Ellen M. Soffin, Davina E. Owen, Graham D Smith, Ceri H. Davies, Sarah C. Lappin, Martin J. Gunthorpe, L. Howett, S. Luis Hannan
Publikováno v:
Neuropharmacology. 46:133-149
Vanilloid receptor-1 (TRPV1) is a non-selective cation channel, predominantly expressed by peripheral sensory neurones, which is known to play a key role in the detection of noxious painful stimuli, such as capsaicin, acid and heat. To date, a number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd1e6a3014674523ef11c19bfa10804
https://doi.org/10.1016/s0028-3908(03)00305-8
https://doi.org/10.1016/s0028-3908(03)00305-8
Publikováno v:
European Journal of Cognitive Psychology. 15:71-100
Three experiments investigated the role of object knowledge on participants' ability to solve a spatial arrangement problem. The task was to rearrange six real-world three-dimensional objects so that their relative locations agreed with a given set o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91cdd57b3b324ecf2c10260f3c326fea
https://doi.org/10.1080/09541440303596
https://doi.org/10.1080/09541440303596
Autor:
Rosemary E. Kelsell, Andrew D. Randall, K. J. Charles, Jeffrey C. Jerman, James Wright, P. Reilly, Darren Smart, Praveen Anand, Julie Egerton, Paul Facer, Lezanne Ooi, Graham D Smith, Philip David Hayes, John B. Davis, Martin J. Gunthorpe, Jean-Philippe Walhin
Publikováno v:
Nature. 418:186-190
Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin. Although VR1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a417c6fe4bde6b11bf2e357ec7c19e19
https://doi.org/10.1038/nature00894
https://doi.org/10.1038/nature00894
Autor:
Veit Flockerzi, Jeff C. Jerman, Phil Hayes, Darren Smart, Guy Droogmans, John B. Davis, Ullrich Wissenbach, William Cairns, Graham D Smith, Christopher D. Benham, Joris Vriens, Hiroyuki Watanabe, Bernd Nilius, Jean Prenen
Publikováno v:
Journal of Biological Chemistry. 277:13569-13577
We have studied activation by phorbol derivatives of TRPV4 channels, the human VRL-2, and murine TRP12 channels, which are highly homologous to the human VR-OAC, and the human and murine OTRPC4 channel. 4alpha-Phorbol 12,13-didecanoate (4alpha-PDD) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb216943b6bb0461a8293817f539f20d
https://doi.org/10.1074/jbc.m200062200
https://doi.org/10.1074/jbc.m200062200