Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Graham D, Hogg"'
Autor:
Vikram S. Pothuri, Graham D. Hogg, Leah Conant, Nicholas Borcherding, C. Alston James, Jacqueline Mudd, Greg Williams, Yongwoo David Seo, William G. Hawkins, Venu G. Pillarisetty, David G. DeNardo, Ryan C. Fields
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is refractory to immune checkpoint inhibitor therapy. However, intratumoral T-cell infiltration correlates with improved overall survival (OS). Herein, we characterized the d
Externí odkaz:
https://doaj.org/article/020545a544174e6986a7dd89b240e669
Autor:
Hui Peng, Lijin Li, Chong Zuo, Michael Y. Chen, Xiuli Zhang, Nancy B. Myers, Graham D. Hogg, David G. DeNardo, S. Peter Goedegebuure, William G. Hawkins, William E. Gillanders
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundCancer neoantigens are important targets of cancer immunotherapy and neoantigen vaccines are currently in development in pancreatic ductal adenocarcinoma (PDAC) and other cancer types. Immune regulatory mechanisms in pancreatic cancer may l
Externí odkaz:
https://doaj.org/article/0e3fe50aa4d44130bd63e7763d67c6e4
Autor:
Laura S. Angelo, Graham D. Hogg, Shawn Abeynaike, Lynn Bimler, Alexander Vargas-Hernandez, Silke Paust
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Human NK cells are comprised of phenotypic subsets, whose potentially unique functions remain largely unexplored. C-X-C-motif-chemokine-receptor-6 (CXCR6)+ NK cells have been identified as phenotypically immature tissue-resident NK cells in mice and
Externí odkaz:
https://doaj.org/article/0f484ddab63049e69061c60021880351
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
The clinical success of immune checkpoint inhibitors has highlighted the central role of the immune system in cancer control. Immune checkpoint inhibitors can reinvigorate anti-cancer immunity and are now the standard of care in a number of malignanc
Externí odkaz:
https://doaj.org/article/d81a72b88600426ebfd1aac8121cf79a
Autor:
C. Alston. James, John M. Baer, Chong Zuo, Usman Y. Panni, Brett L. Knolhoff, Graham D. Hogg, Natalie L. Kingston, Liang-I Kang, Varintra E. Lander, Jingqin Luo, Yu Tao, Mark A. Watson, Rebecca Aft, Ryan C. Fields, William G. Hawkins, David G. DeNardo
Publikováno v:
Cancer Immunology Research.
Intratumoral T-cell dysfunction is a hallmark of pancreatic tumors, and efforts to improve dendritic cell (DC)-mediated T-cell activation may be critical in treating these immune therapy unresponsive tumors. Recent evidence indicates that mechanisms
Autor:
Xiuting Liu, Graham D. Hogg, Chong Zuo, Nicholas C. Borcherding, John M. Baer, Varintra E. Lander, Liang-I Kang, Brett L. Knolhoff, Faiz Ahmad, Robin E. Osterhout, Anna V. Galkin, Jean-Marie Bruey, Laura L. Carter, Cedric Mpoy, Kiran R. Vij, Ryan C. Fields, Julie K. Schwarz, Haeseong Park, Vineet Gupta, David G. DeNardo
Publikováno v:
Cancer Cell.
Autor:
David G. DeNardo, Hyun Kim, Julie K. Schwarz, Buck E. Rogers, Michael Zahner, Jalen Scott, Cedric Mpoy, Daniel P. Lander, Nicholas C. Borcherding, Chong Zuo, John M. Baer, Savannah J. Bogner, Brett L. Knolhoff, Liang-I Kang, Xiuting Liu, Graham D. Hogg, John M. Herndon, Natalie L. Kingston, Jad I. Belle, Varintra E. Lander
The effects of radiotherapy (RT) on tumor immunity in pancreatic ductal adenocarcinoma (PDAC) are not well understood. To better understand if RT can prime antigen-specific T-cell responses, we analyzed human PDAC tissues and mouse models. In both se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f7001041d74584b705d27bbfb384c1
https://doi.org/10.1158/2159-8290.c.6549747
https://doi.org/10.1158/2159-8290.c.6549747
Autor:
David G. DeNardo, Hyun Kim, Julie K. Schwarz, Buck E. Rogers, Michael Zahner, Jalen Scott, Cedric Mpoy, Daniel P. Lander, Nicholas C. Borcherding, Chong Zuo, John M. Baer, Savannah J. Bogner, Brett L. Knolhoff, Liang-I Kang, Xiuting Liu, Graham D. Hogg, John M. Herndon, Natalie L. Kingston, Jad I. Belle, Varintra E. Lander
Supplementary Table from Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79ed75015c59cd30d2021db1b9d2ece
https://doi.org/10.1158/2159-8290.22541799
https://doi.org/10.1158/2159-8290.22541799
Autor:
David G. DeNardo, Hyun Kim, Julie K. Schwarz, Buck E. Rogers, Michael Zahner, Jalen Scott, Cedric Mpoy, Daniel P. Lander, Nicholas C. Borcherding, Chong Zuo, John M. Baer, Savannah J. Bogner, Brett L. Knolhoff, Liang-I Kang, Xiuting Liu, Graham D. Hogg, John M. Herndon, Natalie L. Kingston, Jad I. Belle, Varintra E. Lander
Supplementary Figure from Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f80b39bd397158d0a497c9bb3e7dd92
https://doi.org/10.1158/2159-8290.22541817.v1
https://doi.org/10.1158/2159-8290.22541817.v1
Autor:
Chong Zuo, John M. Baer, Brett L. Knolhoff, Jad I. Belle, Xiuting Liu, Angela Alarcon De La Lastra, Christina Fu, Graham D. Hogg, Natalie L. Kingston, Marcus A. Breden, Paarth B. Dodhiawala, Daniel Cui Zhou, Varintra E. Lander, C. Alston James, Li Ding, Kian-Huat Lim, Ryan C. Fields, William G. Hawkins, Jason D. Weber, Guoyan Zhao, David G. DeNardo
Publikováno v:
Journal of Experimental Medicine. 220
Tumor-associated macrophages (TAMs) are abundant in pancreatic ductal adenocarcinomas (PDACs). While TAMs are known to proliferate in cancer tissues, the impact of this on macrophage phenotype and disease progression is poorly understood. We showed t