Výsledky vyhledávání - "Graham Cotton"

A Comparative Study of Fluorescence Assays in Screening for BRD4

Autor: Helena Lindmark, Pia Hansson, Göran Dahl, Graham Cotton, Colin J. Dunsmore, Klaus Doering, Wayne P. Bowen, Ian L. Dale, Helen Boyd, Felix Nicolaus

Publikováno v: ASSAY and Drug Development Technologies. 16:372-383

Fluorescence assay technologies are commonly used in high-throughput screening because of their sensitivity and ease of use. Different technologies have their characteristics and the rationale for choosing one over the other can differ between projec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f589c412361b4dbfaecf7b27bd40db
https://doi.org/10.1089/adt.2018.850

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Abstract LB096: Development of a next generation ROR1 targeting Protein Drug Conjugate (PDC)

Autor: Chiara Saladino, Andrew C.G. Porter, Estelle McLean, Mark Wappett, Aaron Cranston, Tim Harrison, Stacey Bell, Jennifer Thom, Marina Kovaleva, Aidan P. McCann, Trumper Paul Richard, Graham Cotton, Caroline J. Barelle

Publikováno v: Cancer Research. 81:LB096-LB096

The receptor tyrosine kinase ROR1 is a cell-surface onco-fetal protein expressed on a variety of solid tumours and haematological malignancies, which has limited expression on normal adult tissue. A functional role for ROR1 in tumorigenesis and disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ce5bf11318a700e628c7657f977339e
https://doi.org/10.1158/1538-7445.am2021-lb096

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Abstract 538: Exploiting the properties of VNAR domains for the development of novel efficacious protein drug conjugates targeting the oncofetal protein ROR1

Autor: Marina Kovaleva, Aaron Cranston, Andrew C.G. Porter, Mark Wappett, Estelle McLean, Chiara Saladino, Graham Cotton, Stacey Bell, Andrei Kamenski, Alicia Campion, Trumper Paul Richard, Jennifer Thom, Elisa Persiani, Aidan P. McCann, Caroline J. Barelle, Tim Harrison

Publikováno v: Cancer Research. 80:538-538

The onco-embryonic receptor tyrosine kinase ROR1is a cell-surface protein expressed on a broad range of solid tumours and haematological malignancies but is largely absent from normal adult tissue. Increased ROR1 expression correlates with poor clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c5075206517a9efbcb5c4e86f43aff4
https://doi.org/10.1158/1538-7445.am2020-538

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Single-Domain Antibody-Functionalized pH-Responsive Amphiphilic Block Copolymer Nanoparticles for Epidermal Growth Factor Receptor Targeted Cancer Therapy

Autor: Peter Smyth, Thomas J. Gibson, Efrosyni Themistou, William J. McDaid, Christopher J. Scott, Daniel Lavery, Graham Cotton, Jennifer Thom

Publikováno v: Gibson, T J, Smyth, P, McDaid, W J, Lavery, D, Thom, J, Cotton, G, Scott, C J & Themistou, E 2018, ' Single-Domain Antibody-Functionalized pH-Responsive Amphiphilic Block Copolymer Nanoparticles for Epidermal Growth Factor Receptor Targeted Cancer Therapy ', ACS Macro Letters, vol. 7, no. 8, pp. 1010-1015 . https://doi.org/10.1021/acsmacrolett.8b00461

Biocompatible antibody–nanoparticle conjugates have attracted interest as anticancer agents due to their potential to selectively target therapeutic agents at disease sites. However, new formulation and conjugation approaches are urgently needed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61fc53418af6cc1df8719711505bd07
https://pure.qub.ac.uk/en/publications/9556684f-429d-4c5f-bf7a-b7f1867f6d23

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Abstract 222: Novel protein drug conjugates targeting ROR1 through the development and exploitation of a drug discovery platform based on small, engineered VNAR domains

Autor: Trumper Paul Richard, Stacey Bell, Aaron Cranston, Caroline J. Barelle, Andrew C.G. Porter, Andrei Kamenski, Chiara Saladino, Estelle McLean, Marina Kovaleva, Jennifer Thom, Aidan P. McCann, John Steven, Mark Wappett, Graham Cotton, Tim Harrison

Publikováno v: Cancer Research. 79:222-222

Whilst antibody drug conjugates (ADCs) have been successfully used to target highly potent cytotoxic agents to tumours, there is a continued emphasis on developing technologies for improving the therapeutic effectiveness of this class of agents. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83e6aa33418b4a49d7e79448b51f84c1
https://doi.org/10.1158/1538-7445.am2019-222

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Treatment of inflammatory bowel disease by chemokine receptor-targeted leukapheresis

Autor: Hans Glise, Michael Eberhardson, Ola Winqvist, Martina Jones, Per Karlén, Graham Cotton, Petra Jones, Beatrice Maltman, Kerry Woznica, Per Marits, Mats Karlsson

Publikováno v: Clinical Immunology. 149:73-82

Leukapheresis removes circulating leukocytes en route to the target organ. Hitherto unspecific matrixes have been used to remove leukocytes in inflammatory bowel disease (IBD). This report describes a novel selective leukapheresis column based on che

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3ab94bffaad17a28f5798888961631
https://doi.org/10.1016/j.clim.2013.05.021

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Recombinant Protein Hydrazides: Application to Site-Specific Protein PEGylation

Autor: David E. Anderson, Jennifer Thom, Graham Cotton, Joanne McGregor

Publikováno v: Bioconjugate Chemistry. 22:1017-1020

Here, we describe a novel method for the site-specific C-terminal PEGylation of recombinant proteins. This general approach exploits chemical cleavage of precursor intein-fusion proteins with hydrazine to directly produce recombinant protein hydrazid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91620c1ba434777775c7663a7e63afc9
https://doi.org/10.1021/bc2001374

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