Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Graham Cotton"'
Autor:
Tracy Robson, David G. Hirst, Timothy Harrison, Iain James, Graham Cotton, Joanne McGregor, Jennifer Roberts, David J. J. Waugh, Hayley McKeen, Hayder Dyer, Lynn McCallum, Keeva McClelland, Helen O. McCarthy, Roy Bicknell, Michelle Hookham, Jenny Worthington, Anita Yakkundi, Martin O'Rourke, Andrea Valentine
Purpose: Antiangiogenic therapies can be an important adjunct to the management of many malignancies. Here we investigated a novel protein, FKBPL, and peptide derivative for their antiangiogenic activity and mechanism of action.Experimental Design: R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f1a905491253f0f6b78dd29df57e11
https://doi.org/10.1158/1078-0432.c.6519893
https://doi.org/10.1158/1078-0432.c.6519893
Autor:
Tracy Robson, David G. Hirst, Timothy Harrison, Iain James, Graham Cotton, Joanne McGregor, Jennifer Roberts, David J. J. Waugh, Hayley McKeen, Hayder Dyer, Lynn McCallum, Keeva McClelland, Helen O. McCarthy, Roy Bicknell, Michelle Hookham, Jenny Worthington, Anita Yakkundi, Martin O'Rourke, Andrea Valentine
Supplementary Figures S1-S10; Supplementary Table S1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1487edb7a0c4de2e08a6147ab1954f14
https://doi.org/10.1158/1078-0432.22443617.v1
https://doi.org/10.1158/1078-0432.22443617.v1
Autor:
Graham Cotton, Paul Trumper, Estelle McLean, Mark Wappett, Stacey Bell, Greg Papadakos, Jennifer Thom, Chiara Saladino, Aaron Cranston, Georgiana Parau, Stephanie Gatdula, Stephanie Burton, Aidan McCann, Tim Harrison
Publikováno v:
Cancer Research. 83:LB011-LB011
The placental alkaline phosphatases, ALPP and ALPPL2, are glycosylphosphatidylinositol (GPI)-anchored cell-surface proteins that are expressed in the placenta during fetal development but have very little expression on normal adult tissue. These prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d7e398a812ab096a0512732af277540
https://doi.org/10.1158/1538-7445.am2023-lb011
https://doi.org/10.1158/1538-7445.am2023-lb011
Autor:
Chiara Saladino, Andrew C.G. Porter, Estelle McLean, Mark Wappett, Aaron Cranston, Tim Harrison, Stacey Bell, Jennifer Thom, Marina Kovaleva, Aidan P. McCann, Trumper Paul Richard, Graham Cotton, Caroline J. Barelle
Publikováno v:
Cancer Research. 81:LB096-LB096
The receptor tyrosine kinase ROR1 is a cell-surface onco-fetal protein expressed on a variety of solid tumours and haematological malignancies, which has limited expression on normal adult tissue. A functional role for ROR1 in tumorigenesis and disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ce5bf11318a700e628c7657f977339e
https://doi.org/10.1158/1538-7445.am2021-lb096
https://doi.org/10.1158/1538-7445.am2021-lb096
Autor:
Helena Lindmark, Pia Hansson, Göran Dahl, Graham Cotton, Colin J. Dunsmore, Klaus Doering, Wayne P. Bowen, Ian L. Dale, Helen Boyd, Felix Nicolaus
Publikováno v:
ASSAY and Drug Development Technologies. 16:372-383
Fluorescence assay technologies are commonly used in high-throughput screening because of their sensitivity and ease of use. Different technologies have their characteristics and the rationale for choosing one over the other can differ between projec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f589c412361b4dbfaecf7b27bd40db
https://doi.org/10.1089/adt.2018.850
https://doi.org/10.1089/adt.2018.850
Autor:
Marina Kovaleva, Aaron Cranston, Andrew C.G. Porter, Mark Wappett, Estelle McLean, Chiara Saladino, Graham Cotton, Stacey Bell, Andrei Kamenski, Alicia Campion, Trumper Paul Richard, Jennifer Thom, Elisa Persiani, Aidan P. McCann, Caroline J. Barelle, Tim Harrison
Publikováno v:
Cancer Research. 80:538-538
The onco-embryonic receptor tyrosine kinase ROR1is a cell-surface protein expressed on a broad range of solid tumours and haematological malignancies but is largely absent from normal adult tissue. Increased ROR1 expression correlates with poor clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c5075206517a9efbcb5c4e86f43aff4
https://doi.org/10.1158/1538-7445.am2020-538
https://doi.org/10.1158/1538-7445.am2020-538
Autor:
Trumper Paul Richard, Stacey Bell, Aaron Cranston, Caroline J. Barelle, Andrew C.G. Porter, Andrei Kamenski, Chiara Saladino, Estelle McLean, Marina Kovaleva, Jennifer Thom, Aidan P. McCann, John Steven, Mark Wappett, Graham Cotton, Tim Harrison
Publikováno v:
Cancer Research. 79:222-222
Whilst antibody drug conjugates (ADCs) have been successfully used to target highly potent cytotoxic agents to tumours, there is a continued emphasis on developing technologies for improving the therapeutic effectiveness of this class of agents. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83e6aa33418b4a49d7e79448b51f84c1
https://doi.org/10.1158/1538-7445.am2019-222
https://doi.org/10.1158/1538-7445.am2019-222
Autor:
Peter Smyth, Thomas J. Gibson, Efrosyni Themistou, William J. McDaid, Christopher J. Scott, Daniel Lavery, Graham Cotton, Jennifer Thom
Publikováno v:
Gibson, T J, Smyth, P, McDaid, W J, Lavery, D, Thom, J, Cotton, G, Scott, C J & Themistou, E 2018, ' Single-Domain Antibody-Functionalized pH-Responsive Amphiphilic Block Copolymer Nanoparticles for Epidermal Growth Factor Receptor Targeted Cancer Therapy ', ACS Macro Letters, vol. 7, no. 8, pp. 1010-1015 . https://doi.org/10.1021/acsmacrolett.8b00461
Biocompatible antibody–nanoparticle conjugates have attracted interest as anticancer agents due to their potential to selectively target therapeutic agents at disease sites. However, new formulation and conjugation approaches are urgently needed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61fc53418af6cc1df8719711505bd07
https://pure.qub.ac.uk/en/publications/9556684f-429d-4c5f-bf7a-b7f1867f6d23
https://pure.qub.ac.uk/en/publications/9556684f-429d-4c5f-bf7a-b7f1867f6d23
Autor:
Ian Harley, Adrien Kissenpfenning, Ken Arthur, Laura Nelson, Neermeen Moustafa, Stephanie Annett, Andrea Marshall, Darran P. O'Connor, Gillian Moore, Fiona Furlong, Lana McClements, Tim Harrison, Amy Short, Graham Cotton, Cian M. McCrudden, Helen O. McCarthy, Sudipto Das, Glen McCluggage, Tracy Robson, Anita Yakkundi
Publikováno v:
Cancer Research. 78:LB-054
FKBPL is a secreted protein with well-established anti-angiogenic and anti-cancer stem cell activity. A novel therapeutic peptide, ALM201, derived from this protein has successfully completed a phase I clinical trial and was granted orphan drug statu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e708363eb2c9c37f0812390e30169ce0
https://doi.org/10.1158/1538-7445.am2018-lb-054
https://doi.org/10.1158/1538-7445.am2018-lb-054
Autor:
Hans Glise, Michael Eberhardson, Ola Winqvist, Martina Jones, Per Karlén, Graham Cotton, Petra Jones, Beatrice Maltman, Kerry Woznica, Per Marits, Mats Karlsson
Publikováno v:
Clinical Immunology. 149:73-82
Leukapheresis removes circulating leukocytes en route to the target organ. Hitherto unspecific matrixes have been used to remove leukocytes in inflammatory bowel disease (IBD). This report describes a novel selective leukapheresis column based on che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3ab94bffaad17a28f5798888961631
https://doi.org/10.1016/j.clim.2013.05.021
https://doi.org/10.1016/j.clim.2013.05.021