Generation of an Open-Access Patient-Derived iPSC Biobank for Amyotrophic Lateral Sclerosis Disease Modelling

Autor: Erin C. Hedges, Graham Cocks, Christopher E. Shaw, Agnes L. Nishimura

Publikováno v: Genes; Volume 14; Issue 5; Pages: 1108

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting the upper and lower motor neurons, causing patients to lose control over voluntary movement, and leading to gradual paralysis and death. There is no cure for ALS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62ed3c6fb8d616890d1a7c9785ee93d

Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones

Autor: Cathy Fernandes, Simon Lovestone, Claudie Hooper, Graham Cocks, David Sugden, Richard Killick

Publikováno v: Journal of Neurochemistry. 118:512-520

J. Neurochem. (2011) 118, 512–520. Abstract Glycogen synthase kinase 3 (GSK3) is a widely expressed, constitutively active, serine/threonine kinase that is negatively regulated by both Wnt and insulin via two independent signalling pathways. GSK3 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bf25036b838ce354251f678f1a03cca
https://doi.org/10.1111/j.1471-4159.2011.07349.x

The Thiazolidinedione Pioglitazone Increases Cholesterol Biosynthetic Gene Expression in Primary Cortical Neurons by a PPARγ-Independent Mechanism

Autor: Jill C. Richardson, David Virley, Simon J Graham, Simon Lovestone, Graham Cocks, Jonathan I. Wilde, Vicky Bousgouni

Publikováno v: Journal of Alzheimer's Disease. 19:631-646

In a recent clinical study, the thiazolidinedione (TZD) pioglitazone (Actos was reported to preserve cognitive function in patients with mild to moderate Alzheimer's disease and type II diabetes mellitus. TZDs are agonists of the nuclear hormone rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baeb7ea46a98f636cb6cbd3066b9b279
https://doi.org/10.3233/jad-2010-1266

Neural Plasticity and Neurogenesis in Mental Disorders

Autor: Antonio Egidio Nardi, Graham Cocks, Oscar Arias-Carrión, Mauro Giovanni Carta

Publikováno v: Neural Plasticity, Vol 2016 (2016)
Cocks, G, Carta, M G, Arias-Carrión, O & Nardi, A E 2016, ' Neural Plasticity and Neurogenesis in Mental Disorders ', Neural Plasticity, vol. 2016, 3738015 . https://doi.org/10.1155/2016/3738015
Neural Plasticity

Adult neurogenesis, the continuous generation of newborn neurons in discrete regions of the brain throughout life, is now widely regarded as a fundamental mechanism of neural plasticity. This phenomenon, and in particular the integration of new neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ad3c0470a0a70ad511c962c821beb8
https://doaj.org/article/6390ed80608048af93300b631be67f94

Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents

Autor: Marcella Rietschel, Patricia J. Conrod, Jean-Baptiste Poline, Tobias Banaschewski, Michael N. Smolka, Roberto Toro, Chenyang Tao, Frauke Nees, Lourdes Martinez Medina, Gareth J. Barker, Juergen Gallinat, Christian Büchel, Zdenka Pausova, A. Fernandes, Marie-Laure Paillère Martinot, Tomáš Paus, Tianye Jia, Agnieszka Kepa, Andreas Heinz, Gunter Schumann, Barbara Ruggeri, Eva Loth, Mira Fauth-Bühler, Claire Lawrence, Fabiana M. Carvalho, Mark Lathrop, Herta Flor, Hugh Garavan, Graham Cocks, Anbarasu Lourdusamy, Penny A. Gowland, Rüdiger Brühl, Karl Mann, Sylvane Desrivières, Arun L.W. Bokde, Paul M. Thompson, Jianfeng Feng

Publikováno v: Molecular Psychiatry
Molecular Psychiatry, Nature Publishing Group, 2015, 20 (2), pp.263-274. ⟨10.1038/mp.2013.197⟩
Desrivières, S, Lourdusamy, A, Tao, C, Toro, R, Jia, T, Loth, E, Martinez Medina, L, Kepa, A, Fernandes, A, Ruggeri, B, Mesquita De Carvalho, F, Cocks, G, Banaschewski, T, Barker, G J, Bokde, A L W, Büchel, C, Conrod, P J, Flor, H, Heinz, A, Gallinat, J, Garavan, H, Gowland, P, Brühl, R, Lawrence, C, Mann, K, Martinot, M L P, Nees, F, Lathrop, M, Poline, J-B, Rietschel, M, Thompson, P, Fauth-Bühler, M, Smolka, M N, Pausova, Z, Paus, T, Feng, J, Schumann, G 2015, ' Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents ', Molecular Psychiatry, vol. 20, no. 2, pp. 263-274 . https://doi.org/10.1038/mp.2013.197
Molecular Psychiatry, 2015, 20 (2), pp.263-274. ⟨10.1038/mp.2013.197⟩

International audience; Despite the recognition that cortical thickness is heritable and correlates with intellectual ability in children and adolescents, the genes contributing to individual differences in these traits remain unknown. We conducted a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9cf610602d20bb43cd4d5abc42b575
https://hal-pasteur.archives-ouvertes.fr/pasteur-01967174