Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Graham C. Burdge"'
Autor:
Johanna von Gerichten, Annette L. West, Nicola A. Irvine, Elizabeth A. Miles, Philip C. Calder, Karen A. Lillycrop, Graham C. Burdge, Barbara A. Fielding
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immune function changes across the life stages; for example, senior adults exhibit a tendency towards a weaker cell-mediated immune response and a stronger inflammatory response than younger adults. This might be partly mediated by changes in oxylipi
Externí odkaz:
https://doaj.org/article/49889a51f4af4d36bcb198ad532c0087
Autor:
Annette L. West, Johanna von Gerichten, Nicola A. Irvine, Elizabeth A. Miles, Karen A. Lillycrop, Philip C. Calder, Barbara A. Fielding, Graham C. Burdge
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionImmune function changes across the life course; the fetal immune system is characterised by tolerance while that of seniors is less able to respond effectively to antigens and is more pro-inflammatory than in younger adults. Lipids are in
Externí odkaz:
https://doaj.org/article/adc829dcb3514a6e9c3b6ff1a052bb6a
Autor:
Johanna von Gerichten, Annette L. West, Nicola A. Irvine, Elizabeth A. Miles, Philip C. Calder, Karen A. Lillycrop, Barbara A. Fielding, Graham C. Burdge
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Longer-chain polyunsaturated fatty acids (LCPUFAs) ≥20 carbons long are required for leukocyte function. These can be obtained from the diet, but there is some evidence that leukocytes can convert essential fatty acids (EFAs) into LCPUFAs. We used
Externí odkaz:
https://doaj.org/article/b8a2cba2a0af44c8b88383c9394d7c7a
Autor:
Annette L. West, Elizabeth A. Miles, Lihua Han, Karen A. Lillycrop, Johnathan A. Napier, Philip C. Calder, Graham C. Burdge
Publikováno v:
Nutrients, Vol 13, Iss 9, p 3116 (2021)
Eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) are important for leukocyte function. This study investigated whether consuming transgenic Camelina sativa (tCSO) seed oil containing both 20:5n-3 and 22:6n-3 is as effective as fish
Externí odkaz:
https://doaj.org/article/33be9bdf55f34965aa3ff2f6fb43b0ed
Autor:
Karen Lillycrop, Robert Murray, Clara Cheong, Ai Ling Teh, Rebecca Clarke-Harris, Sheila Barton, Paula Costello, Emma Garratt, Eloise Cook, Philip Titcombe, Bhuvaneshwari Shunmuganathan, Samantha J. Liew, Yong-Cai Chua, Xinyi Lin, Yonghui Wu, Graham C. Burdge, Cyrus Cooper, Hazel M. Inskip, Neerja Karnani, James C. Hopkins, Caroline E. Childs, Carolina Paras Chavez, Philip C. Calder, Fabian Yap, Yung Seng Lee, Yap Seng Chong, Philip E. Melton, Lawrie Beilin, Rae-Chi Huang, Peter D. Gluckman, Nick Harvey, Mark A. Hanson, Joanna D. Holbrook, Keith M. Godfrey
Publikováno v:
EBioMedicine, Vol 19, Iss C, Pp 60-72 (2017)
Experimental studies show a substantial contribution of early life environment to obesity risk through epigenetic processes. We examined inter-individual DNA methylation differences in human birth tissues associated with child's adiposity. We identif
Externí odkaz:
https://doaj.org/article/b50df7b8db9e47929bab8c7d7eb822c2
Publikováno v:
Nutrients, Vol 12, Iss 9, p 2821 (2020)
Folic acid (FA) intake has been associated with increased breast cancer risk in some studies. Although underlying mechanisms are unknown, epigenetic modifications that persistently alter transcription have been suggested. We tested the hypothesis tha
Externí odkaz:
https://doaj.org/article/bde335e5f8184edca44f8da56480dd77
Autor:
Charlene M. Sibbons, Nicola A. Irvine, J. Eduardo Pérez-Mojica, Philip C. Calder, Karen A. Lillycrop, Barbara A. Fielding, Graham C. Burdge
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised. To address this, we measured metabolism of 18:3n-3
Externí odkaz:
https://doaj.org/article/a2774fddb8d8462ab9ce9cd70c2c5036
Publikováno v:
Journal of Nutritional Science, Vol 6 (2017)
Vegetarian diets have been associated with health benefits, but paradoxically are low in EPA and DHA which are important for development, particularly of the central nervous system, and for health. Humans have limited capacity for synthesis of EPA an
Externí odkaz:
https://doaj.org/article/364311fe1d6d49c2a16b7d5f7d007418
Autor:
Tinu M. Samuel, Olga Sakwinska, Kimmo Makinen, Graham C. Burdge, Keith M. Godfrey, Irma Silva-Zolezzi
Publikováno v:
Nutrients, Vol 11, Iss 8, p 1811 (2019)
Preterm birth (PTB) (
Externí odkaz:
https://doaj.org/article/582d47cda24b41d39d33a9c86b2fed7f
Publikováno v:
Journal of Nutritional Science, Vol 5 (2016)
The effect of folic acid (FA) on breast cancer (BC) risk is uncertain. We hypothesised that this uncertainty may be due, in part, to differential effects of FA between BC cells with different phenotypes. To test this we investigated the effect of tre
Externí odkaz:
https://doaj.org/article/d14f3f0f94b5414d9dea728588bdfe81