Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Graham C Burdge"'
Autor:
Elie Antoun, Negusse T Kitaba, Philip Titcombe, Kathryn V Dalrymple, Emma S Garratt, Sheila J Barton, Robert Murray, Paul T Seed, Joanna D Holbrook, Michael S Kobor, David Ts Lin, Julia L MacIsaac, Graham C Burdge, Sara L White, Lucilla Poston, Keith M Godfrey, Karen A Lillycrop, UPBEAT Consortium
Publikováno v:
PLoS Medicine, Vol 17, Iss 11, p e1003229 (2020)
BackgroundHigher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with DNA methylation proposed as a mediating mechanism. Here, we examined the rel
Externí odkaz:
https://doaj.org/article/b2fe24c15dd443af8b059bf9123fd7ff
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189655 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0134664.].
Externí odkaz:
https://doaj.org/article/409a6bfa2b7a4b7aad9bd1cdd138c42c
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134664 (2015)
Environmental challenges such as a high fat diet during pregnancy can induce changes in offspring growth, metabolism and cardiovascular function. However, challenges that are sustained over several generations can induce progressive compensatory meta
Externí odkaz:
https://doaj.org/article/c2a1b67857ab481aafa4b7f3b4947e3a
Autor:
Kirsten R Poore, Lisa J Hollis, Robert J S Murray, Anna Warlow, Andrew Brewin, Laurence Fulford, Jane K Cleal, Karen A Lillycrop, Graham C Burdge, Mark A Hanson, Lucy R Green
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90994 (2014)
Epidemiological and experimental studies suggest early nutrition has long-term effects on susceptibility to obesity, cardiovascular and metabolic diseases. Small and large animal models confirm the influence of different windows of sensitivity, from
Externí odkaz:
https://doaj.org/article/de02fa258a244a46a646d6378a239ebb
Autor:
Samuel P Hoile, Rebecca Clarke-Harris, Rae-Chi Huang, Philip C Calder, Trevor A Mori, Lawrence J Beilin, Karen A Lillycrop, Graham C Burdge
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109896 (2014)
BACKGROUND: Studies in animal models and in cultured cells have shown that fatty acids can induce alterations in the DNA methylation of specific genes. There have been no studies of the effects of fatty acid supplementation on the epigenetic regulati
Externí odkaz:
https://doaj.org/article/ddf7ca4d96a74467b8edaf82bce9a49d
Autor:
Emma S Garratt, Mark H Vickers, Peter D Gluckman, Mark A Hanson, Graham C Burdge, Karen A Lillycrop
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67483 (2013)
The genes encoding nuclear receptors comprise multiple 5'untranslated exons, which give rise to several transcripts encoding the same protein, allowing tissue-specific regulation of expression. Both human and mouse peroxisome proliferator activated r
Externí odkaz:
https://doaj.org/article/9d5ac0576ac94c59b3a2599802ae6705
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81476 (2013)
This paper presents data from the English Channel area of Britain and Northern France on the spatial distribution of Lower to early Middle Palaeolithic pre-MIS5 interglacial sites which are used to test the contention that the pattern of the richest
Externí odkaz:
https://doaj.org/article/cd21c7cbd4a0426badec0ab32b0391e8
Autor:
Christopher J Kelsall, Samuel P Hoile, Nicola A Irvine, Mojgan Masoodi, Christopher Torrens, Karen A Lillycrop, Philip C Calder, Geraldine F Clough, Mark A Hanson, Graham C Burdge
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34492 (2012)
Nutrition during development affects risk of future cardiovascular disease. Relatively little is known about whether the amount and type of fat in the maternal diet affect vascular function in the offspring. To investigate this, pregnant and lactatin
Externí odkaz:
https://doaj.org/article/a0c577fd1fc54c9184075dc376e5c946
Autor:
Graham C Burdge, Samuel P Hoile, Tobias Uller, Nicola A Thomas, Peter D Gluckman, Mark A Hanson, Karen A Lillycrop
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28282 (2011)
Induction of altered phenotypes during development in response to environmental input involves epigenetic changes. Phenotypic traits can be passed between generations by a variety of mechanisms, including direct transmission of epigenetic states or b
Externí odkaz:
https://doaj.org/article/613b9b6dc8ed490b98b01b78106c67bf
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21668 (2011)
There is considerable evidence for non-genomic transmission between generations of phenotypes induced by environmental exposures during development, although the mechanism is poorly understood. We investigated whether alterations in expression of the
Externí odkaz:
https://doaj.org/article/b890200c793943f58e520c22c82a707e