Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Graham C, Burdge"'
Autor:
Johanna von Gerichten, Annette L. West, Nicola A. Irvine, Elizabeth A. Miles, Philip C. Calder, Karen A. Lillycrop, Graham C. Burdge, Barbara A. Fielding
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immune function changes across the life stages; for example, senior adults exhibit a tendency towards a weaker cell-mediated immune response and a stronger inflammatory response than younger adults. This might be partly mediated by changes in oxylipi
Externí odkaz:
https://doaj.org/article/49889a51f4af4d36bcb198ad532c0087
Autor:
Annette L. West, Johanna von Gerichten, Nicola A. Irvine, Elizabeth A. Miles, Karen A. Lillycrop, Philip C. Calder, Barbara A. Fielding, Graham C. Burdge
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionImmune function changes across the life course; the fetal immune system is characterised by tolerance while that of seniors is less able to respond effectively to antigens and is more pro-inflammatory than in younger adults. Lipids are in
Externí odkaz:
https://doaj.org/article/adc829dcb3514a6e9c3b6ff1a052bb6a
Autor:
Johanna von Gerichten, Annette L. West, Nicola A. Irvine, Elizabeth A. Miles, Philip C. Calder, Karen A. Lillycrop, Barbara A. Fielding, Graham C. Burdge
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Longer-chain polyunsaturated fatty acids (LCPUFAs) ≥20 carbons long are required for leukocyte function. These can be obtained from the diet, but there is some evidence that leukocytes can convert essential fatty acids (EFAs) into LCPUFAs. We used
Externí odkaz:
https://doaj.org/article/b8a2cba2a0af44c8b88383c9394d7c7a
Autor:
Elie Antoun, Negusse T Kitaba, Philip Titcombe, Kathryn V Dalrymple, Emma S Garratt, Sheila J Barton, Robert Murray, Paul T Seed, Joanna D Holbrook, Michael S Kobor, David Ts Lin, Julia L MacIsaac, Graham C Burdge, Sara L White, Lucilla Poston, Keith M Godfrey, Karen A Lillycrop, UPBEAT Consortium
Publikováno v:
PLoS Medicine, Vol 17, Iss 11, p e1003229 (2020)
BackgroundHigher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with DNA methylation proposed as a mediating mechanism. Here, we examined the rel
Externí odkaz:
https://doaj.org/article/b2fe24c15dd443af8b059bf9123fd7ff
Autor:
Karen Lillycrop, Robert Murray, Clara Cheong, Ai Ling Teh, Rebecca Clarke-Harris, Sheila Barton, Paula Costello, Emma Garratt, Eloise Cook, Philip Titcombe, Bhuvaneshwari Shunmuganathan, Samantha J. Liew, Yong-Cai Chua, Xinyi Lin, Yonghui Wu, Graham C. Burdge, Cyrus Cooper, Hazel M. Inskip, Neerja Karnani, James C. Hopkins, Caroline E. Childs, Carolina Paras Chavez, Philip C. Calder, Fabian Yap, Yung Seng Lee, Yap Seng Chong, Philip E. Melton, Lawrie Beilin, Rae-Chi Huang, Peter D. Gluckman, Nick Harvey, Mark A. Hanson, Joanna D. Holbrook, Keith M. Godfrey
Publikováno v:
EBioMedicine, Vol 19, Iss C, Pp 60-72 (2017)
Experimental studies show a substantial contribution of early life environment to obesity risk through epigenetic processes. We examined inter-individual DNA methylation differences in human birth tissues associated with child's adiposity. We identif
Externí odkaz:
https://doaj.org/article/b50df7b8db9e47929bab8c7d7eb822c2
Autor:
Nicola A. Irvine, Annette L. West, Johanna Von Gerichten, Elizabeth A. Miles, Karen A. Lillycrop, Philip C. Calder, Barbara A. Fielding, Graham C. Burdge
Publikováno v:
Lipids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2865f07964dd9023e6979f1208466b6b
https://doi.org/10.1002/lipd.12372
https://doi.org/10.1002/lipd.12372
Autor:
Charlene M. Sibbons, Nicola A. Irvine, J. Eduardo Pérez-Mojica, Philip C. Calder, Karen A. Lillycrop, Barbara A. Fielding, Graham C. Burdge
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised. To address this, we measured metabolism of 18:3n-3
Externí odkaz:
https://doaj.org/article/a2774fddb8d8462ab9ce9cd70c2c5036
Autor:
Phillip E Melton, Mark A Burton, Karen Lillycrop, Keith M Godfrey, Sebastian Rauschert, Denise Anderson, Graham C Burdge, Trevor A Mori, Lawrence J Beilin, Oyekoya T Ayonrinde, Jeffery M Craig, John K Olynyk, Joanna D Holbrook, Craig E Pennell, Wendy H Oddy, Eric K Moses, Leon A Adams, Rae-Chi Huang
BACKGROUND AND AIMS: Epigenetic modifications are associated with hepatic fat accumulation and non-alcoholic fatty liver disease (NAFLD). However, few epigenetic modifications directly implicated in such processes have been identified during adolesce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff3be1c541cf31b93b30a6c7dc658a83
https://doi.org/10.21203/rs.3.rs-2114814/v1
https://doi.org/10.21203/rs.3.rs-2114814/v1
Autor:
Elie Antoun, Keith M. Godfrey, Graham C. Burdge, Charles Peebles, Julian Halcox, Jennifer Bryant, P A Mahon, Karen A. Lillycrop, Philip Titcombe, Elizabeth A Ellins, John E. Deanfield, Cyrus Cooper, Mark A. Hanson, Hazel Inskip, Robert Murray, Negusse T. Kitaba, Sheila J. Barton
Publikováno v:
Hypertension (Dallas, Tex. : 1979)
Supplemental Digital Content is available in the text.
Increases in aortic pulse wave velocity, a measure of arterial stiffness, can lead to elevated systolic blood pressure and increased cardiac afterload in adulthood. These changes are detecta
Increases in aortic pulse wave velocity, a measure of arterial stiffness, can lead to elevated systolic blood pressure and increased cardiac afterload in adulthood. These changes are detecta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e382fc065de5498b99fd7a67d9476417
http://europepmc.org/articles/PMC8357051
http://europepmc.org/articles/PMC8357051
Publikováno v:
Journal of Nutritional Science, Vol 6 (2017)
Vegetarian diets have been associated with health benefits, but paradoxically are low in EPA and DHA which are important for development, particularly of the central nervous system, and for health. Humans have limited capacity for synthesis of EPA an
Externí odkaz:
https://doaj.org/article/364311fe1d6d49c2a16b7d5f7d007418