Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Graham Andrew Showell"'
Publikováno v:
Lead Generation
Autor:
Ian N. Fleming, Graham Andrew Showell, Claudine Gaudon, Christian Burschka, Jürgen O. Daiss, Diana Ivanova, Hinrich Gronemeyer, John S. Mills, Reinhold Tacke, John Gary Montana
Publikováno v:
Organometallics. 24:3192-3199
Twofold sila-substitution (C/Si exchange) in the saturated ring of the tetrahydronaphthalene skeleton of the RXR-selective retinoid agonist bexarotene (1a) leads to disila-bexarotene (1b). Compound 1b was synthesized in a multistep synthesis, startin
Autor:
Hiroaki Ueno, Robert Apaya, Tomonori Arai, Robert George Boyle, Etsuko Wada, Toshiro Sakaki, Yoshihiro Usui, Tim Mitchell, Hiroaki Iijima, Keiji Wada, Graham Andrew Showell, Hiroshi Shimada, John Humphries
Publikováno v:
Journal of Peptide Science. 11:136-141
Extensive SAR studies on the unselective BRS3 agonist, [H-D-Phe6,β-Ala11,Phe13,Nle14]-bombesin-(6-14)-nonapeptide amide, have highlighted structural features important for BRS3 activity and have provided guidance as to the design of selective agonis
Autor:
Graham Andrew Showell, John S. Mills
Publikováno v:
Expert Opinion on Investigational Drugs. 13:1149-1157
There remains considerable pressure on the pharmaceutical industry to increase productivity and reduce the attrition of drug candidates. Genomics, parallel chemistry and high-throughput biology have not yielded the anticipated benefits, resulting in
Autor:
John S. Mills, Graham Andrew Showell
Publikováno v:
Drug Discovery Today. 8:551-556
During the lead optimization phase of drug discovery projects, the factors contributing to subsequent failure might include poor portfolio decision-making and a sub-optimal intellectual property (IP) position. The pharmaceutical industry has an ongoi
Autor:
Graham Andrew Showell, Sylvie Bourrain
Publikováno v:
Synthesis. 1994:505-508
A mild reduction method of C3-oximido-1,4-benzodiazepines to afford the C3-amino derivatives is described. The key step involves the formation of a carbamate oxime intermediate. The greater reactivity of the C3-(ethylaminocarbonyl)oximido-1,4-benzodi
Autor:
Raymond Baker, C. Kneen, John Saunders, Kevin John Merchant, Tracey L. Gibbons, Graham Andrew Showell, Stephen B. Freedman, Shailendra Patel, Angus Murray Macleod
Publikováno v:
ChemInform. 22
Recent studies have described novel azabicycle-based muscarinic agonists which readily penetrate into the central nervous system and are capable of displaying high efficacy at cortical sites. The current paper describes the synthesis and biochemical
Autor:
Graham Andrew Showell, R. Baker, Richard Hargreaves, K. Woodford, Shil Patel, Timothy M. Willson, Ian Stansfield, R. J. Snow, S. Connolly, Stephen B. Freedman
Publikováno v:
ChemInform. 25
Autor:
Graham Andrew Showell, Sylvie Bourrain
Publikováno v:
ChemInform. 25
A mild reduction method of C3-oximido-1,4-benzodiazepines to afford the C3-amino derivatives is described. The key step involves the formation of a carbamate oxime intermediate. The greater reactivity of the C3-(ethylaminocarbonyl)oximido-1,4-benzodi
Autor:
Robert Edward Mackenzie, Christopher Higgs, Steve Price, Graham Andrew Showell, Tina J. Wilkinson, Hazel J. Hunt, Jenny A. Chadwick, John Gary Montana
Publikováno v:
ChemInform. 40