Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Graham Allaway"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Chalcone derivatives are shown to possess excellent anti-inflammatory and anti-oxidant properties which are of great interest in treating respiratory diseases such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), chronic obstru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1147941c77077a0f4b27fd54f7c4213a
http://link.springer.com/article/10.1038/s41598-020-76585-2
http://link.springer.com/article/10.1038/s41598-020-76585-2
Autor:
Christiana N. Teijaro, Wayne E. Childers, Srinivas Papaiahgari, Magid Abou-Gharbia, Nicole Lounsbury, Min Ye, George Mateo, Rajash K. Thimmulappa, Kenneth R. Korzekwa, Shyam Biswal, Graham Allaway, Brielle Jones, John Gordon
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:5352-5359
Nrf2 activators represent a good drug target for designing agents to treat diseases associated with oxidative stress. Building upon previous work, we designed and prepared a series of heterocyclic chalcone-based Nrf2 activators with reduced lipophili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803033a2b45cc24d7af9187d0d6675fe
https://doi.org/10.1016/j.bmc.2015.07.056
https://doi.org/10.1016/j.bmc.2015.07.056
Autor:
Carl T. Wild, Donglei Yu, Lan Xie, Jim Turpin, Graham Allaway, Kuo Hsiung Lee, Philip C. Smith
Publikováno v:
Journal of Medicinal Chemistry. 47:756-760
To enhance the water solubility and oral bioavailability of DCK analogues, 12 new mono- and disubstituted (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogues were synthesized and evaluated for inhibition of HIV-1 replication in H9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6490069ca1481210b04abb55fdbc48
https://doi.org/10.1021/jm030416y
https://doi.org/10.1021/jm030416y
Autor:
Graham Allaway, Brielle Jones, Roberta Goncalves Marangoni, Hongyan Zhu, Mitra Bhattachayya, Warren G. Tourtellotte, Gabriel Lord, Shyam Biswal, Jun Wei, John Varga, Benjamin D. Korman
Publikováno v:
Transl Res
The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) governs antioxidant, innate immune and cytoprotective responses and its deregulation is prominent in chronic inflammatory conditions. To examine the hypothesis that Nrf2 migh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b6f00454fa20efd0a64049a4fe32f1
https://doi.org/10.1016/j.trsl.2016.12.002
https://doi.org/10.1016/j.trsl.2016.12.002
Autor:
Ting Zhou, Lan Xie, Chun Hong Zhao, Graham Allaway, Hai-Feng Chen, Chen Yang Zhao, Bo Tao Fan, Kuo Hsiung Lee
Publikováno v:
Journal of computer-aided molecular design. 19(4)
Molecular docking and molecular dynamics simulation were applied to study the binding mode of 3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs anti-HIV inhibitors with HIV-1 RT. The results suggest that there is a strong hydrogen bond betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6819ae5aacafb9f93c936ba5e765f5e
https://pubmed.ncbi.nlm.nih.gov/16163451
https://pubmed.ncbi.nlm.nih.gov/16163451