Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Graham A. McGibbon"'
Publikováno v:
Drug Discovery Today. 19:1691-1695
Within the pharmaceutical industry, the rapid identification, elucidation and characterization of synthetic or process impurities or degradants form an intense and a comprehensive undertaking. Advances in laboratory hardware and software are changing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4687ddd7d3fbc1da0e7d9e29972f4e45
https://doi.org/10.1016/j.drudis.2014.07.003
https://doi.org/10.1016/j.drudis.2014.07.003
Autor:
Steven M. Musser, Timothy R. Croley, John H. Callahan, Margaret Antler, Vitaly Lashin, Kevin D. White, Graham A. McGibbon, Jon W. Wong
Publikováno v:
Journal of Separation Science. 36:971-979
Increasing importation of food and the diversity of potential contaminants have necessitated more analytical testing of these foods. Historically, mass spectrometric methods for testing foods were confined to monitoring selected ions (SIM or MRM), ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0622b9f3dac0ea54295064758edde09d
https://doi.org/10.1002/jssc.201200348
https://doi.org/10.1002/jssc.201200348
Publikováno v:
European Journal of Mass Spectrometry, 18(2), 149-159. I M Publications
Early combined computational and experimental studies by J.K. Terlouw and colleagues propose that low-energy methyl carbamate ions, NH2COOCH3•+ (MC-1), rearrange into distonic ions NH2C(OH)OCH2•+ and hydrogen-bridged radical cations [NH2C=O–H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382062129183c80ed9fc9894441f3711
https://doi.org/10.1255/ejms.1164
https://doi.org/10.1255/ejms.1164
Publikováno v:
Genetic Engineering & Biotechnology News. 37:26-27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1d0364378f6d6083544a843cb14a0d2
https://doi.org/10.1089/gen.37.20.14
https://doi.org/10.1089/gen.37.20.14
Publikováno v:
Rapid Communications in Mass Spectrometry. 21:1546-1554
Phosphorylation is one of the key events in signal transduction and zinc plays an important catalytic and/or structural role in many biological systems. The binding of Zn to a phosphopeptide will alter the physiological functions of a peptide. The bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e93a4c9350018f13c34d9e42c412e0
https://doi.org/10.1002/rcm.2992
https://doi.org/10.1002/rcm.2992
Autor:
David M Hambly, Christiane Yoakim, Peter W. White, Jerry L. Hopkins, Jacques Archambault, Graham A. McGibbon, William W. Ogilvie, Ingrid Guse, Walter Davidson, Lee Frego, Pierre Lavallee
Publikováno v:
Analytical Chemistry. 76:2095-2102
An indandione-containing class of inhibitors abrogates DNA replication of human papillomavirus (HPV) types 6 and 11 by binding reversibly to the transactivation domain (TAD) of the viral E2 protein and inhibiting its interaction with the viral E1 hel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1875149eded3b7f2d1b40b1dcf6aaa
https://doi.org/10.1021/ac035335o
https://doi.org/10.1021/ac035335o
Autor:
Jeff A. O'Meara, Peter W. White, Christiane Yoakim, Nathalie Goudreau, Graham A. McGibbon, William W. Ogilvie
Publikováno v:
Helvetica Chimica Acta. 86:3427-3444
A novel series of inhibitors of the HPV11 E1E2 proteinprotein interaction was identified. These inhibitors, which were discovered as a result of high-throughput screening, feature an indandione system spiro-fused onto an appropriately substituted tet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be893f4802f1cb9d4a4c21242fceed5d
https://doi.org/10.1002/hlca.200390287
https://doi.org/10.1002/hlca.200390287
Autor:
Johan K. Terlouw, Wolfram Koch, Helmut Schwarz, Thomas K. Dargel, David J. Lavorato, Graham A. McGibbon
Publikováno v:
International Journal of Mass Spectrometry. :43-57
The potential energy surface comprising ionized pyrimidine, 1 ·+ , and eight of its hydrogen-shift isomers, as well as that of the corresponding neutrals was explored at a level of theory (B3LYP/TZVP) that has proven adequate for related species. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e28b7b69dfc8476a6d6449d771d53be
https://doi.org/10.1016/s1387-3806(01)00410-9
https://doi.org/10.1016/s1387-3806(01)00410-9
Publikováno v:
Biochemistry. 40:1196-1204
The E6 Zn(2+)-binding protein of high-risk human papillomaviruses (HPVs) is one of the major transforming proteins encoded by these tumor viruses. A bacterial system was used to express wild type and truncated forms of HPV-16 E6 linked to GST. The re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc6058a13a5288c480d3497ae7554bbf
https://doi.org/10.1021/bi001837+
https://doi.org/10.1021/bi001837+
Autor:
Lorne M. Fell, Graham A. McGibbon, David J. Lavorato, Helmut Schwarz, Johan K. Terlouw, Semia Sen
Publikováno v:
International Journal of Mass Spectrometry. :71-83
The decarbonylation reactions of ionized 2-acetylpyridine, 2-acetylpyrazine, and 2-acetylthiazole have been investigated using the multiple collision technique of neutralization–reionization/collision-induced dissociation mass spectrometry and rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ec03b2272076d43757306326facb644
https://doi.org/10.1016/s1387-3806(99)00147-5
https://doi.org/10.1016/s1387-3806(99)00147-5