Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Graham A. Hudson"'
Autor:
Xiaoyue Chen, Graham A. Hudson, Charlotte Mineo, Bashar Amer, Edward E. K. Baidoo, Samantha A. Crowe, Yuzhong Liu, Jay D. Keasling, Henrik V. Scheller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Methyl jasmonate (MeJA) is a known elicitor of plant specialized metabolism, including triterpenoid saponins. Saponaria vaccaria is an annual herb used in traditional Chinese medicine, containing large quantities of oleanane-type triterpenoi
Externí odkaz:
https://doaj.org/article/23753f5fb290452c9ffd93a7880a98f0
Autor:
Brandon J. Burkhart, Nidhi Kakkar, Graham A. Hudson, Wilfred A. van der Donk, Douglas A. Mitchell
Publikováno v:
ACS Central Science, Vol 3, Iss 6, Pp 629-638 (2017)
Externí odkaz:
https://doaj.org/article/016abb2db56b48568e2788557924e1a9
Autor:
Dinh T. Nguyen, Tung T. Le, Andrew J. Rice, Graham A. Hudson, Wilfred A. van der Donk, Douglas A. Mitchell
Publikováno v:
Journal of the American Chemical Society. 144:11263-11269
Macrocyclic peptides are sought-after molecular scaffolds for drug discovery, and new methods to access diverse libraries are of increasing interest. Here, we report the enzymatic synthesis of pyridine-based macrocyclic peptides (pyritides) from line
Publikováno v:
Org Lett
The structural and functional characterization of natural products is vastly outpaced by the bioinformatic identification of biosynthetic gene clusters (BGCs) that encode such molecules. Uniting our knowledge of bioinformatics and enzymology to predi
Publikováno v:
J Am Chem Soc
Lasso peptides are a class of ribosomally synthesized and post-translationally modified natural product which possess a unique lariat knot conformation. The low entropy "threaded" conformation endows lasso peptides with considerable resistance to hea
Autor:
Xiaorui Guo, Patricia M. B. Saint-Vincent, Douglas A. Mitchell, Lonnie A. Harris, Graham A. Hudson
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a family of natural products defined by a genetically encoded precursor peptide that is tailored by associated biosynthetic enzymes to form the mature product. Lasso pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59eff4f4540356532b40c2e1420234e9
https://doi.org/10.1101/2020.07.16.207027
https://doi.org/10.1101/2020.07.16.207027
Owing to advances in genomic sequencing and bioinformatics, the breadth of natural product biosynthetic gene clusters (BGCs) has meteorically risen. This remains true for ribosomally synthesized and post-translationally modified peptides (RiPPs), whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b00678fc0f03b8f551fbcde86b8364b
https://doi.org/10.26434/chemrxiv.11971950
https://doi.org/10.26434/chemrxiv.11971950
Autor:
Graham A. Hudson, Douglas A. Mitchell
Publikováno v:
Current Opinion in Microbiology. 45:61-69
The threat of antibiotic resistant bacterial infections continues to underscore the need for new treatment options. Historically, small molecule metabolites from microbes have provided a rich source of antibiotic compounds, and as a result, significa
Publikováno v:
Journal of the American Chemical Society. 140:9494-9501
Thiopeptides are members of the ribosomally synthesized and posttranslationally modified peptides (RiPP) family of natural products. Most characterized thiopeptides display nanomolar potency towards Gram-positive bacteria by blocking protein translat
Autor:
Zhengan Zhang, Graham A. Hudson, Wilfred A. van der Donk, Nilkamal Mahanta, Douglas A. Mitchell
Publikováno v:
Journal of the American Chemical Society
The past decade has seen the discovery of four different classes of radical S-adenosylmethionine (rSAM) methyltransferases that methylate unactivated carbon centers. Whereas the mechanism of class A is well understood, the molecular details of methyl