Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Graham, R. Scott"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract To better understand functional morphological adaptations to high elevation (> 3000 m above sea level) life in both North American and African mountain-associated rodents, we used microCT scanning to acquire 3D images and a 3D morphometric a
Externí odkaz:
https://doaj.org/article/133d5850e8cb4d1b97e46926b9fb931b
Publikováno v:
Current Research in Physiology, Vol 5, Iss , Pp 83-92 (2022)
Studies of animals native to high altitude can provide valuable insight into physiological mechanisms and evolution of performance in challenging environments. We investigated how mechanisms controlling cardiovascular function may have evolved in dee
Externí odkaz:
https://doaj.org/article/76d8fc8a322848ea9da90ea70736fed1
Autor:
James J. Yu, Amy L. Non, Erica C. Heinrich, Wanjun Gu, Joe Alcock, Esteban A. Moya, Elijah S. Lawrence, Michael S. Tift, Katie A. O'Brien, Jay F. Storz, Anthony V. Signore, Jane I. Khudyakov, William K. Milsom, Sean M. Wilson, Cynthia M. Beall, Francisco C. Villafuerte, Tsering Stobdan, Colleen G. Julian, Lorna G. Moore, Mark M. Fuster, Jennifer A. Stokes, Richard Milner, John B. West, Jiao Zhang, John Y. Shyy, Ainash Childebayeva, José Pablo Vázquez-Medina, Luu V. Pham, Omar A. Mesarwi, James E. Hall, Zachary A. Cheviron, Jeremy Sieker, Arlin B. Blood, Jason X. Yuan, Graham R. Scott, Brinda K. Rana, Paul J. Ponganis, Atul Malhotra, Frank L. Powell, Tatum S. Simonson
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypo
Externí odkaz:
https://doaj.org/article/ad6281793d794d10a1e325e2249296a9
Autor:
Oliver H. Wearing, Catherine M. Ivy, Natalia Gutiérrez-Pinto, Jonathan P. Velotta, Shane C. Campbell-Staton, Chandrasekhar Natarajan, Zachary A. Cheviron, Jay F. Storz, Graham R. Scott
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-15 (2021)
Abstract Background Complex organismal traits are often the result of multiple interacting genes and sub-organismal phenotypes, but how these interactions shape the evolutionary trajectories of adaptive traits is poorly understood. We examined how fu
Externí odkaz:
https://doaj.org/article/fbe09799084040bdac218fcb486a398c
Autor:
Fu, Thomas C., Ratcliffe, Toby, O'Shea, Thomas T., Brucker, Kyle A., Graham, R. Scott, Wyatt, Donald C.
In order to support development of computational fluid dynamics codes for high-speed, small-craft applications, laboratory experiments were performed on a representative of Deep-V planing craft model. The measurements included resistance, sinkage and
Externí odkaz:
http://arxiv.org/abs/1410.1818
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Developmental plasticity can elicit phenotypic adjustments that help organisms cope with environmental change, but the relationship between developmental plasticity and plasticity in adult life (e.g., acclimation) remains unresolved. We sought to exa
Externí odkaz:
https://doaj.org/article/b6e0fd198614413f98732db194c9470c
Publikováno v:
eLife, Vol 9 (2020)
High-altitude environments require that animals meet the metabolic O2 demands for locomotion and thermogenesis in O2-thin air, but the degree to which convergent metabolic changes have arisen across independent high-altitude lineages or the speed at
Externí odkaz:
https://doaj.org/article/794e9188d0404fd48dfdbf6c1c989f20
Publikováno v:
The Journal of Physiology. 600:4207-4225
The gene encoding HIF-2α, Epas1, has experienced a history of natural selection in many high-altitude taxa, but the functional role of mutations in this gene is still poorly understood. We investigated the influence of the high-altitude variant of E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5897f31189b1241407c550c6ebbe392
https://doi.org/10.1113/jp282798
https://doi.org/10.1113/jp282798
Autor:
Rena M Schweizer, Jonathan P Velotta, Catherine M Ivy, Matthew R Jones, Sarah M Muir, Gideon S Bradburd, Jay F Storz, Graham R Scott, Zachary A Cheviron
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008420 (2019)
Evolutionary adaptation to extreme environments often requires coordinated changes in multiple intersecting physiological pathways, but how such multi-trait adaptation occurs remains unresolved. Transcription factors, which regulate the expression of
Externí odkaz:
https://doaj.org/article/1101ce9a66604d08a7115ab8108773a7
Autor:
Hanley, Daniel F, Thompson, Richard E, Muschelli, John, Rosenblum, Michael, McBee, Nichol, Lane, Karen, Bistran-Hall, Amanda J, Mayo, Steven W, Keyl, Penelope, Gandhi, Dheeraj, Morgan, Tim C, Ullman, Natalie, Mould, W Andrew, Carhuapoma, J Ricardo, Kase, Carlos, Ziai, Wendy, Thompson, Carol B, Yenokyan, Gayane, Huang, Emily, Broaddus, William C, Graham, R Scott, Aldrich, E Francois, Dodd, Robert, Wijman, Cristanne, Caron, Jean-Louis, Huang, Judy, Camarata, Paul, Mendelow, A David, Gregson, Barbara, Janis, Scott, Vespa, Paul, Martin, Neil, Awad, Issam, Zuccarello, Mario
Publikováno v:
In The Lancet Neurology November 2016 15(12):1228-1237