Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Graham, Duddy"'
Autor:
Rinako Nakagawa, Miriam Llorian, Sunita Varsani-Brown, Probir Chakravarty, Jeannie M. Camarillo, David Barry, Roger George, Neil P. Blackledge, Graham Duddy, Neil L. Kelleher, Robert J. Klose, Martin Turner, Dinis P. Calado
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract To increase antibody affinity against pathogens, positively selected GC-B cells initiate cell division in the light zone (LZ) of germinal centers (GCs). Among these, higher-affinity clones migrate to the dark zone (DZ) and vigorously prolife
Externí odkaz:
https://doaj.org/article/84234ec349554abfa6f1048d4cadc502
Autor:
Morag A. Lewis, Maria Lachgar-Ruiz, Francesca Di Domenico, Graham Duddy, Jing Chen, Sergio Fernandez, Matias Morin, Gareth Williams, Miguel Angel Moreno Pelayo, Karen P. Steel
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Progressive hearing loss is a common problem in the human population with no effective therapeutics currently available. However, it has a strong genetic contribution, and investigating the genes and regulatory interactions underl
Externí odkaz:
https://doaj.org/article/18ebda7be878464080ab6f75b1462e0e
Autor:
Hillary Elrick, Kevin A. Peterson, Brandon J. Willis, Denise G. Lanza, Elif F. Acar, Edward J. Ryder, Lydia Teboul, Petr Kasparek, Marie-Christine Birling, David J. Adams, Allan Bradley, Robert E. Braun, Steve D. Brown, Adam Caulder, Gemma F. Codner, Francesco J. DeMayo, Mary E. Dickinson, Brendan Doe, Graham Duddy, Marina Gertsenstein, Leslie O. Goodwin, Yann Hérault, Lauri G. Lintott, K. C. Kent Lloyd, Isabel Lorenzo, Matthew Mackenzie, Ann-Marie Mallon, Colin McKerlie, Helen Parkinson, Ramiro Ramirez-Solis, John R. Seavitt, Radislav Sedlacek, William C. Skarnes, Damien Smedley, Sara Wells, Jacqueline K. White, Joshua A. Wood, International Mouse Phenotyping Consortium, Stephen A. Murray, Jason D. Heaney, Lauryl M. J. Nutter
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight into gene function. The IMPC now uses the programmable RNA-guided nuclease Cas9 for i
Externí odkaz:
https://doaj.org/article/0788cc9d0e59472c90243baecc221f96
Autor:
Graham Duddy, Katherine Courtis, Juliette Horwood, Jessica Olsen, Helen Horsler, Tina Hodgson, Sunita Varsani-Brown, Abdullah Abdullah, Laura Denti, Hollie Lane, Fabio Delaqua, Julia Janzen, Molly Strom, Ian Rosewell, Katharine Crawley, Benjamin Davies
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background The ability of recombinant adeno-associated virus to transduce preimplantation mouse embryos has led to the use of this delivery method for the production of genetically altered knock-in mice via CRISPR-Cas9. The potential exists
Externí odkaz:
https://doaj.org/article/95b5ec7dd7854bb08b37eb55094b38d8
Autor:
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Multiple mechanisms of immune evasion exploited by cancer cells have been described. Here, the authors show that genetic inactivation or pharmacological inhibition of tumor-induced Th2-mediated de novo steroidogenesis are sufficient to restore an eff
Externí odkaz:
https://doaj.org/article/3d1388c6f86c4110af3e985cacb07322
Autor:
Martin Steger, Francesca Tonelli, Genta Ito, Paul Davies, Matthias Trost, Melanie Vetter, Stefanie Wachter, Esben Lorentzen, Graham Duddy, Stephen Wilson, Marco AS Baptista, Brian K Fiske, Matthew J Fell, John A Morrow, Alastair D Reith, Dario R Alessi, Matthias Mann
Publikováno v:
eLife, Vol 5 (2016)
Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein, comprise the predominant genetic cause of Parkinson's disease (PD). G2019S, the most common amino acid substitution activates the kinase two- to threefold.
Externí odkaz:
https://doaj.org/article/409b18202ccc444788ac40f61b9a7b0c
Autor:
Elif F. Acar, Luis Santos, Graham Duddy, Adam Caulder, Yann Herault, Joshua A. Wood, Jing Zhao, John R. Seavitt, Masaru Tamura, Martin Hrabĕ de Angelis, Gemma F. Codner, Helen Parkinson, Marie-Christine Birling, Lauryl M. J. Nutter, Jason D. Heaney, Radislav Sedlacek, Brandon J. Willis, Susan Marschall, Kevin A. Peterson, Marina Gertsenstein, Alba Gomez-Segura, Allan Bradley, Je Kyung Seong, Lydia Teboul, Kevin C K Lloyd, Fabio Mammano, Jacqueline K. White, Mary E. Dickinson, Francesco Chiani, Matthew Mackenzie, Robert Braun, Isabel Lorenzo, Colin McKerlie, Wolfgang Wurst, Edward Ryder, Cunxiang Ju, Denise G. Lanza, Ruairidh King, Alessia Gambadoro, Ho Lee, Zhiwei Liu, Ramiro Ramirez-Solis, Ann-Marie Mallon, William C. Skarnes, Xiang Gao, Stephen A. Murray, Francesco J. DeMayo, Lauri G. Lintott, Terrence F. Meehan, Fei Zhou, Hannah Wardle-Jones, Shinya Ayabe, Mark T. Ruhe, Atsushi Yoshiki, Brendan Doe, Peter Matthews, Sara Wells, Hillary Elrick, Claudia Seisenberger, David J. Adams, Jie Zhang, Damien Smedley, Petr Kasparek, Daekee Lee, Leslie O. Goodwin
The International Mouse Phenotyping Consortium (IMPC) is generating and phenotyping null mutations for every protein-coding gene in the mouse1,2. The IMPC now uses Cas9, a programmable RNA-guided nuclease that has revolutionized mouse genome editing3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a11a6fcaf64d723a4f023abdfe162834
https://doi.org/10.1101/2021.10.06.463037
https://doi.org/10.1101/2021.10.06.463037
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e107437 (2014)
Apoptosis signal-regulating kinase-1 (ASK1) is a mitogen-activated protein 3 kinase (MAPKKK/MAP3K) which lies upstream of the stress-activated MAPKs, JNK and p38. ASK1 may be activated by a variety of extracellular and intracellular stimuli. MAP kina
Externí odkaz:
https://doaj.org/article/47cb404664bc4db785d05a4d7dc70f58
Autor:
Angela Deakin, Graham Duddy, Steve Wilson, Steve Harrison, Judi Latcham, Mick Fulleylove, Sylvia Fung, Jason Smith, Mike Pedrick, Tom McKevitt, Leigh Felton, Joanne Morley, Diana Quint, Dilniya Fattah, Brian Hayes, Jade Gough, Roberto Solari
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107490 (2014)
Interleukin-2 inducible tyrosine kinase (ITK) is expressed in T cells and plays a critical role in signalling through the T cell receptor. Evidence, mainly from knockout mice, has suggested that ITK plays a particularly important function in Th2 cell
Externí odkaz:
https://doaj.org/article/d1d949c2f0704f36a96334e7c5b4b83c
Autor:
Klaus Okkenhaug, Edward Ryder, Izabela Walczak, Sarah A. Teichmann, Lia S. Campos, Jacqueline D. Shields, Nuno A. Fonseca, Bidesh Mahata, Angela Riedel, David J. Adams, Xi Chen, Jhuma Pramanik, Krzysztof Polanski, Gozde Kar, Louise van der Weyden, Kousik Kundu, Graham Duddy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
bioRxiv
Nature Communications
bioRxiv
Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to evade anti-tumor immunity. Using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11aa4b3c8b61151e053e9deb0002f2f
https://www.repository.cam.ac.uk/handle/1810/308612
https://www.repository.cam.ac.uk/handle/1810/308612