Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Graeme Winter"'
Autor:
Kamel El Omari, Ramona Duman, Vitaliy Mykhaylyk, Christian M. Orr, Merlyn Latimer-Smith, Graeme Winter, Vinay Grama, Feng Qu, Kiran Bountra, Hok Sau Kwong, Maria Romano, Rosana I. Reis, Lutz Vogeley, Luca Vecchia, C. David Owen, Sina Wittmann, Max Renner, Miki Senda, Naohiro Matsugaki, Yoshiaki Kawano, Thomas A. Bowden, Isabel Moraes, Jonathan M. Grimes, Erika J. Mancini, Martin A. Walsh, Cristiane R. Guzzo, Raymond J. Owens, E. Yvonne Jones, David G. Brown, Dave I. Stuart, Konstantinos Beis, Armin Wagner
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Despite recent advances in cryo-electron microscopy and artificial intelligence-based model predictions, a significant fraction of structure determinations by macromolecular crystallography still requires experimental phasing, usually by mea
Externí odkaz:
https://doaj.org/article/8684a241320c432f8b25757e0cf6d695
Autor:
Herbert J. Bernstein, Andreas Förster, Asmit Bhowmick, Aaron S. Brewster, Sandor Brockhauser, Luca Gelisio, David R. Hall, Filip Leonarski, Valerio Mariani, Gianluca Santoni, Clemens Vonrhein, Graeme Winter
Publikováno v:
IUCrJ, Vol 7, Iss 5, Pp 784-792 (2020)
Macromolecular crystallography (MX) is the dominant means of determining the three-dimensional structures of biological macromolecules. Over the last few decades, most MX data have been collected at synchrotron beamlines using a large number of diffe
Externí odkaz:
https://doaj.org/article/480c9cbf00654de3b0dd4bf579ed9f2e
Autor:
James M. Parkhurst, Andrea Thorn, Melanie Vollmar, Graeme Winter, David G. Waterman, Luis Fuentes-Montero, Richard J. Gildea, Garib N. Murshudov, Gwyndaf Evans
Publikováno v:
IUCrJ, Vol 4, Iss 5, Pp 626-638 (2017)
An algorithm for modelling the background for each Bragg reflection in a series of X-ray diffraction images containing Debye–Scherrer diffraction from ice in the sample is presented. The method involves the use of a global background model which is
Externí odkaz:
https://doaj.org/article/d34cbd0f1e4e45eeb904b3c52112dd06
Autor:
Rubén M. Buey, David Fernández-Justel, Íñigo Marcos-Alcalde, Graeme Winter, Paulino Gómez-Puertas, José María de Pereda, José Luis Revuelta
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Inosine-5′-monophosphate dehydrogenase (IMPDH) is an essential enzyme for nucleotide metabolism and cell proliferation. Despite IMPDH is the target of drugs with antiviral, immunosuppressive and antitumor activities, its physiological mech
Externí odkaz:
https://doaj.org/article/e25f495f01384a6dbd80c2e6b87dba31
Autor:
David . R Allan, Harriott Nowell, Sarah A. Barnett, Mark R. Warren, Adrian Wilcox, Jeppe Christensen, Lucy K. Saunders, Andrew Peach, Mark T. Hooper, Ljubo Zaja, Suren Patel, Leo Cahill, Russell Marshall, Steven Trimnell, Andrew J. Foster, Trevor Bates, Simon Lay, Mark A. Williams, Paul V. Hathaway, Graeme Winter, Markus Gerstel, Ron W. Wooley
Publikováno v:
Crystals, Vol 7, Iss 11, p 336 (2017)
Herein, we describe the development of a novel dual air-bearing fixed-χ diffractometer for beamline I19 at Diamond Light Source. The diffractometer is designed to facilitate the rapid data collections possible with a Dectris Pilatus 2M pixel-array p
Externí odkaz:
https://doaj.org/article/c99b1736e1fc47bbac385fa72ff8adfc
Autor:
Richard J. Gildea, James Beilsten-Edmands, Danny Axford, Sam Horrell, Pierre Aller, James Sandy, Juan Sanchez-Weatherby, C. David Owen, Petra Lukacik, Claire Strain-Damerell, Robin L. Owen, Martin A. Walsh, Graeme Winter
In macromolecular crystallography radiation damage limits the amount of data that can be collected from a single crystal. It is often necessary to merge data sets from multiple crystals, for example small-wedge data collections on micro-crystals, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ac3f4f9e771b864d8687b12c1e77e7
https://doi.org/10.1101/2022.01.17.476589
https://doi.org/10.1101/2022.01.17.476589
Autor:
Benjamin H. Williams, Richard J. Gildea, James Beilsten-Edmands, Gwyndaf Evans, David McDonagh, David G. Waterman, Elena Pascal, Graeme Winter, Markus Gerstel, Nicholas E. Devenish
Publikováno v:
Protein Science : A Publication of the Protein Society
The DIALS software for the processing of X‐ray diffraction data is presented, with an emphasis on how the suite may be used as a toolkit for data processing. The description starts with an overview of the history and intent of the toolkit, usage as
Autor:
Christine J. Cardin, Holly Abell, Thomas Sorensen, Kane McQuaid, John A. Brazier, James P. Hall, Graeme Winter, Sarah P. Gurung, David R. Allan, David J. Cardin
Publikováno v:
Angewandte Chemie International Edition. 58:9881-9885
Using X-ray crystallography, we show an enantiospecificity in DNA G-quadruplex binding, using the complexes Λ/∆-[Ru(TAP)2(dppz-11-CN)]2+ (TAP=1,4,5,8-tetraazaphenanthrene) containing the dppz (dipyridophenazine) ligand, paralleling the specificity
Autor:
Katherine McAuley, David R. Hall, Neil G. Paterson, Alun W. Ashton, Melanie Vollmar, John H. Beale, Danny Axford, Robin L. Owen, Graeme Winter, Markus Gerstel, Richard J. Gildea, Ralf Flaig
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
Different modes of data collection are explored, and the effect of flux and multiplicity on the resulting quality of the data set is discussed. Advice is offered on how to collect data in the absence of prior knowledge of the sample.
Strategies
Strategies
Autor:
Richard J. Gildea, James M. Parkhurst, James Beilsten-Edmands, Gwyndaf Evans, David G. Waterman, Graeme Winter
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
A new scaling program is presented with new features to support multi-sweep workflows and analysis within the DIALS software package.
In processing X-ray diffraction data, the intensities obtained from integration of the diffraction images must
In processing X-ray diffraction data, the intensities obtained from integration of the diffraction images must