Multidimensional separation methods

Autor: Graeme T Clark

Publikováno v: Advanced LC-MS Applications in Bioanalysis. :100-114

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::253896f2b1c0a13e3bcd16ebf9640b92
https://doi.org/10.4155/fseb2013.14.2

A validated bioanalytical method in mouse, rat, rabbit and human plasma for the quantification of one of the steroid glycosides found in Hoodia gordonii extract

Autor: Graeme T Clark, Kun Nang Cheng, Paul J. Russell, Weijun Wang, Derek Lewis

Publikováno v: Food and Chemical Toxicology. 50:S14-S19

Hoodia gordonii extract contains steroid glycosides, fatty acids, plant sterols and polar organic material. Certain steroid glycosides show appetite suppressant activities following oral ingestion. This study describes the validation of a bioanalytic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da8a5b9a95620400197e3cca6c09fc7
https://doi.org/10.1016/j.fct.2010.08.014

Utilization of DBS within drug discovery: development of a serial microsampling pharmacokinetic study in mice

Autor: Graeme T Clark, Lisa Burrows, Mark A.J. Bayliss, Julian J Haynes

Publikováno v: Bioanalysis. 2:1477-1488

Background: Dried blood spots (DBS) are rapidly gaining a foothold in the pharmaceutical industry. However, applications in exploratory drug discovery are limited mainly owing to method development time. The development of a generic DBS assay is pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adffa2f4e185f27a7bd637d84d1ee6b
https://doi.org/10.4155/bio.10.91

DNA sequence and analysis of human chromosome 9

Autor: L K Colman, S S White, R Heathcott, K D Ambrose, C Griffiths, C L Bagguley, Christine Lloyd, Jim Davies, James G. R. Gilbert, Richard Durbin, Carol Scott, Rebekah Hall, Graeme Bethel, Adrienne Hunt, C Carder, A Tromans, G Tamlyn-Hall, Jane Rogers, J Garnett, L M Faulkner, J C Chapman, Benjamin Phillimore, M Grant, A Wild, Christopher J. Gillson, S Hammond, A K Babbage, Sophie Palmer, C. D. Skuce, V. Cobley, Margaret A. Leversha, Robert W. Plumb, J. M. Wallis, Lucy Matthews, Sarah E. Smith, Mark Griffiths, Karen Oliver, J Tester, Christopher M. Johnson, M Earthrowl, K L Novik, Graeme T Clark, Kirsten McLay, Michelle Smith, R M Younger, T Nickerson, K F Barlow, A. King, S. M. Clegg, Mark T. Ross, K M Culley, R. E. Collier, K Bates, Nigel P. Carter, Sarah E. Hunt, Matthew Humphries, Kevin L. Howe, R Ainscough, Matthew Jones, J P Almeida, Laurens G. Wilming, R Patel, C M Clee, A M Kimberley, David Niblett, Gareth Maslen, Jane E. Loveland, Pawandeep Dhami, J C Wyatt, Philip Howden, Harminder Sehra, N Corby, Stephan Beck, Andrew J. Mungall, Cordelia Langford, Mohammed J. R. Ghori, O. T. McCann, Sarah Milne, Ian Dunham, C A Edwards, J Y Brown, Matthew Dunn, A J Theaker, Darren Grafham, Alan Tracey, S. Searle, Anne Parker, John Burton, Amanda McMurray, H Whittaker, R I S Ashwell, M Mashreghi-Mohammadi, P Garner, A J Brown, O. Beasley, Michele Clamp, A Thorpe, Daniel Leongamornlert, Alan Coulson, Y. Ramsey, Paul Wray, N Sycamore, Helen Beasley, M. J F Moore, Dave Willey, K M Porter, S Y Clark, A I Peck, Tim Hubbard, D. M. Lloyd, David R. Bentley, A Joy, Joanna Harley, L Spraggon, J Lovell, Anthony P. West, E. Hart, Adam Frankish, M. Kay, Catherine M. Rice, Matthew D. Francis, S A Ranby, Duncan W. Thomas, Elizabeth J. Huckle, T. E. Wilmer, Sean Humphray, L Young, W Burrill, David Beare, B Tubby, S Lawlor, E Sheridan, Susan M. Gribble, J Frankland, A E Ellington, Charles A. Steward, K S Halls, Roger Horton, Melanie M. Wall, James C. Mullikin, D C Burford, S. Holmes, L M Gilby, T D Andrews, Christine P. Bird, Gareth R. Howell, Stephen Keenan, Joanna Collins, S. Squares, Ruby Banerjee, Jennifer L. Ashurst, Sarah Sims, S Bray-Allen, Lisa French, G. J. Coville, Paul Heath, A. V. Pearce, S. Whitehead, Sancha Martin, J Bailey, J Brook, Darren Barker, Rebecca Glithero, Jonathan Wood, E K Overton-Larty, K A Evans, S. Blakey, John Sulston, Gavin K. Laird, Sam Phillips, S J McLaren

Publikováno v: Nature. 429:369-374

Chromosome 9 is highly structurally polymorphic. It contains the largest autosomal block of heterochromatin, which is heteromorphic in 6–8% of humans, whereas pericentric inversions occur in more than 1% of the population. The finished euchromatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb4a5947796c48eccf8e948aa91b0c7
https://doi.org/10.1038/nature02465

Molecular Species Compositions of Lung and Pancreas Phospholipids in the cftrtm1HGU/tm1HGU Cystic Fibrosis Mouse

Autor: Gunnar A. Rau, Graeme T Clark, Wolfgang Bernhard, Heike Dombrowsky, Anthony D. Postle

Publikováno v: Pediatric Research. 53:447-454

Fatty acid analysis of phospholipid compositions of lung and pancreas cells from a cystic fibrosis transmembrane regulator (CFTR) negative mouse (cftr(-/-))suggested that a decreased concentration of docosahexaenoate (22:6(n-3)) and increased arachid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a33d7cf8bf417b23ea34bae4fbb8ecc
https://doi.org/10.1203/01.pdr.0000049937.30305.8a