Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Graeme R. Polglase"'
Autor:
Nhi T. Tran, Tayla R. Penny, Kyra YY. Chan, Tanya Tang, Paris C. Papagianis, Tara Sepehrizadeh, Lakshmi Nekkanti, Valerie A. Zahra, Yen Pham, Tamara Yawno, Ilias Nitsos, Sharmony B. Kelly, Alison M. Thiel, Michael de Veer, Dhafer M. Alahmari, Michael C. Fahey, Graham Jenkin, Suzanne L. Miller, Robert Galinsky, Graeme R. Polglase, Courtney A. McDonald
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Background Umbilical cord blood (UCB) cells are a promising treatment for preterm brain injury. Access to allogeneic sources of UCB cells offer the potential for early administration to optimise their therapeutic capacities. As preterm infan
Externí odkaz:
https://doaj.org/article/63029373acc54afda5379e952d0ff53a
Autor:
Nhi T. Tran, Ainsley Somers, Kayla Vidinopoulos, Zahrah Azman, Yen Pham, Valerie A. Zahra, Kyra Y. Y. Chan, Stuart Hooper, Kelly Crossley, Beth J. Allison, Robert Galinsky, Graeme R. Polglase
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
BackgroundIntrauterine inflammation and the requirement for mechanical ventilation independently increase the risk of perinatal brain injury and adverse neurodevelopmental outcomes. We aimed to investigate the effects of mechanical ventilation for 24
Externí odkaz:
https://doaj.org/article/fce67349576d456e89f4d7172178fa66
Autor:
Amy E. Sutherland, Tegan A. White, Charmaine R. Rock, Beth R. Piscopo, Ingrid Dudink, Ishmael M. Inocencio, Zahrah Azman, Yen Pham, Ilias Nitsos, Atul Malhotra, Tamara Yawno, Graeme R. Polglase, Graham Jenkin, Emily J. Camm, Beth J. Allison, Suzanne L. Miller
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionFetal growth restriction (FGR) is a common pregnancy complication, caused by placental insufficiency, with serious adverse consequences for development in utero and postnatal wellbeing. There are no antenatal treatments to improve growth
Externí odkaz:
https://doaj.org/article/a7afa6dae9ba4286895b477cbdface19
Autor:
Sharmony B. Kelly, Nhi T. Tran, Graeme R. Polglase, Rodney W. Hunt, Marcel F. Nold, Claudia A. Nold-Petry, David M. Olson, Sylvain Chemtob, Gregory A. Lodygensky, Sarah A. Robertson, Alistair J. Gunn, Robert Galinsky
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-32 (2023)
Abstract Background Perinatal infection/inflammation is associated with a high risk for neurological injury and neurodevelopmental impairment after birth. Despite a growing preclinical evidence base, anti-inflammatory interventions have not been esta
Externí odkaz:
https://doaj.org/article/87c87a74a2394d7895a2c8b4332b8133
Autor:
Sharmony B. Kelly, Justin M. Dean, Valerie A. Zahra, Ingrid Dudink, Alison Thiel, Graeme R. Polglase, Suzanne L. Miller, Stuart B. Hooper, Laura Bennet, Alistair J. Gunn, Robert Galinsky
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Background Antenatal infection/inflammation is associated with disturbances in neuronal connectivity, impaired cortical growth and poor neurodevelopmental outcomes. The pathophysiological substrate that underpins these changes is poorly unde
Externí odkaz:
https://doaj.org/article/1f903e9009bd4f5ebe1ea75988b5b813
Autor:
Kayla Vidinopoulos, Zahrah Azman, Ainsley Somers, Valerie A. Zahra, Alison Thiel, Hui Lu, Yen Pham, Nhi Thao Tran, Beth J. Allison, Eric Herlenius, Stuart Hooper, Robert Galinsky, Graeme R. Polglase
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundPreterm infants have immature respiratory drive and often require prolonged periods of mechanical ventilation. Prolonged mechanical ventilation induces systemic inflammation resulting in ventilation-induced brain injury, however its effect
Externí odkaz:
https://doaj.org/article/68d582654d2f4ff98d19a48637566150
Autor:
Ronny Knol, Emma Brouwer, Thomas van den Akker, Philip L. J. DeKoninck, Enrico Lopriore, Wes Onland, Marijn J. Vermeulen, M. Elske van den Akker–van Marle, Leti van Bodegom–Vos, Willem P. de Boode, Anton H. van Kaam, Irwin K. M. Reiss, Graeme R. Polglase, G. Jeroen Hutten, Sandra A. Prins, Estelle E. M. Mulder, Christian V. Hulzebos, Sam J. van Sambeeck, Mayke E. van der Putten, Inge A. Zonnenberg, Stuart B. Hooper, Arjan B. te Pas
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background International guidelines recommend delayed umbilical cord clamping (DCC) up to 1 min in preterm infants, unless the condition of the infant requires immediate resuscitation. However, clamping the cord prior to lung aeration may se
Externí odkaz:
https://doaj.org/article/2fb64afd5a3448d788ba7e123007bfe5
Autor:
Douglas A. Blank, Kelly J. Crossley, Alison Thiel, Karyn A. Rodgers, Valerie Zahra, Martin Kluckow, Andrew W. Gill, Graeme R. Polglase, Stuart B. Hooper
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundUmbilical cord milking (UCM) at birth causes surges in arterial blood pressure and blood flow to the brain, which may explain the high risk of intraventricular haemorrhage (IVH) in extremely preterm infants receiving UCM. This high risk of
Externí odkaz:
https://doaj.org/article/5bb8cad6c704499384a4f54528361ea5
Autor:
Sharmony B. Kelly, Vanesa Stojanovska, Valerie A. Zahra, Alison Moxham, Suzanne L. Miller, Timothy J. M. Moss, Stuart B. Hooper, Marcel F. Nold, Claudia A. Nold-Petry, Justin M. Dean, Laura Bennet, Graeme R. Polglase, Alistair J. Gunn, Robert Galinsky
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Background Increased systemic and tissue levels of interleukin (IL)-1β are associated with greater risk of impaired neurodevelopment after birth. In this study, we tested the hypothesis that systemic IL-1 receptor antagonist (Ra) administra
Externí odkaz:
https://doaj.org/article/a2f347fac5804c11839aa4e5e942f790
Autor:
Kyra YY Chan, Nhi T. Tran, Paris C. Papagianis, Valerie A. Zahra, Ilias Nitsos, Alison M. Moxham, Domenic A. LaRosa, Courtney McDonald, Suzanne L. Miller, Robert Galinsky, Dhafer M. Alahmari, Vanesa Stojanovska, Graeme R. Polglase
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Initiation of respiratory support in the delivery room increases the risk and severity of brain injury in preterm neonates through two major pathways: an inflammatory pathway and a haemodynamic pathway. The relative contribution of each pathway on pr
Externí odkaz:
https://doaj.org/article/e2325f45e7b043978331bc6b943fff3a