Zobrazeno 1 - 10
of 616
pro vyhledávání: '"Graeme Milligan"'
Autor:
Mausam Kalita, Jun Hyung Park, Renesmee Chenting Kuo, Samira Hayee, Sara Marsango, Valentina Straniero, Israt S. Alam, Angelie Rivera-Rodriguez, Mallesh Pandrala, Mackenzie L. Carlson, Samantha T. Reyes, Isaac M. Jackson, Lorenzo Suigo, Audrey Luo, Sydney C. Nagy, Ermanno Valoti, Graeme Milligan, Frezghi Habte, Bin Shen, Michelle L. James
Publikováno v:
JACS Au, Vol 3, Iss 12, Pp 3297-3310 (2023)
Externí odkaz:
https://doaj.org/article/809eacb49e1c4dafa4e7d776f1a34874
Autor:
Xuan Zhang, Yujing Wang, Shreyas Supekar, Xu Cao, Jingkai Zhou, Jessica Dang, Siqi Chen, Laura Jenkins, Sara Marsango, Xiu Li, Guibing Liu, Graeme Milligan, Mingye Feng, Hao Fan, Weimin Gong, Cheng Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract GPR84 is a unique orphan G protein-coupled receptor (GPCR) that can be activated by endogenous medium-chain fatty acids (MCFAs). The signaling of GPR84 is largely pro-inflammatory, which can augment inflammatory response, and GPR84 also func
Externí odkaz:
https://doaj.org/article/f928a8c42c4f4cda90c65d67e6687d23
Autor:
Natasja Barki, Laura Jenkins, Sara Marsango, Domonkos Dedeo, Daniele Bolognini, Louis Dwomoh, Aisha M Abdelmalik, Margaret Nilsen, Manon Stoffels, Falko Nagel, Stefan Schulz, Andrew B Tobin, Graeme Milligan
Publikováno v:
eLife, Vol 12 (2023)
Free fatty acid receptor 2 (FFAR2) is activated by short-chain fatty acids and expressed widely, including in white adipocytes and various immune and enteroendocrine cells. Using both wild-type human FFAR2 and a designer receptor exclusively activate
Externí odkaz:
https://doaj.org/article/9b6b31128d5a4d21aaccb0f61f49509e
Autor:
Natasja Barki, Daniele Bolognini, Ulf Börjesson, Laura Jenkins, John Riddell, David I Hughes, Trond Ulven, Brian D Hudson, Elisabeth Rexen Ulven, Niek Dekker, Andrew B Tobin, Graeme Milligan
Publikováno v:
eLife, Vol 11 (2022)
Volatile small molecules, including the short-chain fatty acids (SCFAs), acetate and propionate, released by the gut microbiota from the catabolism of nondigestible starches, can act in a hormone-like fashion via specific G-protein-coupled receptors
Externí odkaz:
https://doaj.org/article/0b08f246bde34112a3c8bb4e1ef6d6fa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12237 (2022)
FFA1 and FFA4, two G protein-coupled receptors that are activated by long chain fatty acids, play crucial roles in mediating many biological functions in the body. As a result, these fatty acid receptors have gained considerable attention due to thei
Externí odkaz:
https://doaj.org/article/f6e4024084b44f5688d80cfbd6915407
Autor:
Valentin Sencio, Adeline Barthelemy, Luciana P. Tavares, Marina G. Machado, Daphnée Soulard, Céline Cuinat, Celso Martins Queiroz-Junior, Marie-Louise Noordine, Sophie Salomé-Desnoulez, Lucie Deryuter, Benoit Foligné, Céline Wahl, Benoit Frisch, Angelica T. Vieira, Christophe Paget, Graeme Milligan, Trond Ulven, Isabelle Wolowczuk, Christelle Faveeuw, Ronan Le Goffic, Muriel Thomas, Stéphanie Ferreira, Mauro M. Teixeira, François Trottein
Publikováno v:
Cell Reports, Vol 30, Iss 9, Pp 2934-2947.e6 (2020)
Summary: Secondary bacterial infections often complicate viral respiratory infections. We hypothesize that perturbation of the gut microbiota during influenza A virus (IAV) infection might favor respiratory bacterial superinfection. Sublethal infecti
Externí odkaz:
https://doaj.org/article/09663ef56a7e41888b718db1c3193a50
Autor:
Paulius Viskaitis, Elaine E. Irvine, Mark A. Smith, Agharul I. Choudhury, Elisa Alvarez-Curto, Justyna A. Glegola, Darran G. Hardy, Silvia M.A. Pedroni, Maria R. Paiva Pessoa, Anushka B.P. Fernando, Loukia Katsouri, Alessandro Sardini, Mark A. Ungless, Graeme Milligan, Dominic J. Withers
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3559-3572 (2017)
Summary: Feeding requires the integration of homeostatic drives with emotional states relevant to food procurement in potentially hostile environments. The ventromedial hypothalamus (VMH) regulates feeding and anxiety, but how these are controlled in
Externí odkaz:
https://doaj.org/article/81e3234bc5b2496cb0686f51772bf269
Autor:
Sara Marsango, Gianluigi Caltabiano, Mireia Jiménez-Rosés, Mark J. Millan, John D. Pediani, Richard J. Ward, Graeme Milligan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated
Externí odkaz:
https://doaj.org/article/3470a476fb0447e9a1e204628cce051b
Autor:
Vanessa Segura, Miguel Pérez-Aso, Fermí Montó, Elena Carceller, María Antonia Noguera, John Pediani, Graeme Milligan, Ian Christie McGrath, Pilar D'Ocon
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64996 (2013)
AIMS: To compare the constitutive and agonist-dependent endosomal trafficking of α(1A)- and α(1B)-adrenoceptors (ARs) and to establish if the internalization pattern determines the signaling pathways of each subtype. METHODS: Using CypHer5 technolo
Externí odkaz:
https://doaj.org/article/18a98db5f7dc479da6aaa518089cf63d
Autor:
Selim Terhzaz, Pablo Cabrero, Joris H Robben, Jonathan C Radford, Brian D Hudson, Graeme Milligan, Julian A T Dow, Shireen-A Davies
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29897 (2012)
The capa peptide receptor, capaR (CG14575), is a G-protein coupled receptor (GPCR) for the D. melanogaster capa neuropeptides, Drm-capa-1 and -2 (capa-1 and -2). To date, the capa peptide family constitutes the only known nitridergic peptides in inse
Externí odkaz:
https://doaj.org/article/699601c8b5a04899a2f4191f1060209b