Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Graeme M, Birdsey"'
Autor:
Rakshin Kharwadkar, Benjamin J. Ulrich, Michelle Chu, Byunghee Koh, Matthew M. Hufford, Yongyao Fu, Graeme M. Birdsey, Bo T. Porse, Anna M. Randi, Mark H. Kaplan
Publikováno v:
The Journal of Immunology. 210:537-546
CD4+ TH cells develop into subsets that are specialized in the secretion of particular cytokines to mediate restricted types of inflammation and immune responses. Among the subsets that promote development of allergic inflammatory responses, IL-9–p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b7d6c84c4170873d620b8d400d2304
https://doi.org/10.4049/jimmunol.2200113
https://doi.org/10.4049/jimmunol.2200113
Autor:
Jesus M. Gomez-Salinero, Tomer Itkin, Sean Houghton, Chaitanya Badwe, Yang Lin, Viktoria Kalna, Neil Dufton, Claire R. Peghaire, Masataka Yokoyama, Matthew Wingo, Tyler M. Lu, Ge Li, Jenny Zhaoying Xiang, Yen-Michael Sheng Hsu, David Redmond, Ryan Schreiner, Graeme M. Birdsey, Anna M. Randi, Shahin Rafii
Publikováno v:
Nat Cardiovasc Res
Current dogma dictates that, during adulthood, endothelial cells (ECs) are locked in an immutable stable homeostatic state. By contrast, herein we show that maintenance of EC fate and function are linked and active processes, which depend on the cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dc7f27b353db6352209a28670cb752
https://doi.org/10.1038/s44161-022-00128-3
https://doi.org/10.1038/s44161-022-00128-3
Autor:
Neil P. Dufton, Claire R. Peghaire, Lourdes Osuna-Almagro, Claudio Raimondi, Viktoria Kalna, Abhishek Chauhan, Gwilym Webb, Youwen Yang, Graeme M. Birdsey, Patricia Lalor, Justin C. Mason, David H. Adams, Anna M. Randi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The transcription factor ERG is key to endothelial lineage specification and vascular homeostasis. Here the authors show that ERG balances TGFβ signalling through the SMAD1 and SMAD3 pathways, protecting the endothelium from endothelial-to-mesenchym
Externí odkaz:
https://doaj.org/article/688d3e51bd6e4384bf9ccbf1181bb7d6
Autor:
Elena Garonna, Kathleen M Botham, Graeme M Birdsey, Anna M Randi, Ruben R Gonzalez-Perez, Caroline P D Wheeler-Jones
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0223400 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0018823.].
Externí odkaz:
https://doaj.org/article/6a3c8a93e9404fdc803d8b32072ab164
Autor:
Christopher M. Schafer, Silvia Martin-Almedina, Katarzyna Kurylowicz, Neil Dufton, Lourdes Osuna-Almagro, Meng-Ling Wu, Charmain F. Johnson, Aarti V. Shah, Dorian O. Haskard, Andrianna Buxton, Erika Willis, Kate Wheeler, Sean Turner, Magdalena Chlebicz, Rizaldy P. Scott, Susan Kovats, Audrey Cleuren, Graeme M. Birdsey, Anna M. Randi, Courtney T. Griffin
Publikováno v:
bioRxiv
BackgroundDuring infectious diseases, pro-inflammatory cytokines transiently destabilize interactions between adjacent vascular endothelial cells (ECs) to facilitate the passage of immune molecules and cells into tissues. However, in the lung the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526ae34af15f04eccb276895f65dccd1
https://doi.org/10.1101/2023.02.08.527788
https://doi.org/10.1101/2023.02.08.527788
Autor:
Neil P. Dufton, Claire R. Peghaire, Lourdes Osuna-Almagro, Claudio Raimondi, Viktoria Kalna, Abhishek Chauhan, Gwilym Webb, Youwen Yang, Graeme M. Birdsey, Patricia Lalor, Justin C. Mason, David H. Adams, Anna M. Randi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/09a0a6c4e2f844d885132da763c799de
Autor:
Gabriela D'Amico, Isabelle Fernandez, Jesús Gómez-Escudero, Hyojin Kim, Eleni Maniati, Muhammad Syahmi Azman, Faraz K. Mardakheh, Bryan Serrels, Alan Serrels, Maddy Parsons, Anthony Squire, Graeme M. Birdsey, Anna M. Randi, Alfonso Bolado-Carrancio, Rathi Gangeswaran, Louise E. Reynolds, Natalia Bodrug, Yaohe Wang, Jun Wang, Pascal Meier, Kairbaan M. Hodivala-Dilke
Publikováno v:
D'amico, G, Fernandez, I, Gómez-escudero, J, Kim, H, Maniati, E, Azman, M S, Mardakheh, F K, Serrels, B, Serrels, A, Parsons, M, Squire, A, Birdsey, G M, Randi, A M, Bolado-carrancio, A, Gangeswaran, R, Reynolds, L E, Bodrug, N, Wang, Y, Wang, J, Meier, P & Hodivala-dilke, K M 2022, ' ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning ', Development, vol. 149, no. 13, dev200528 . https://doi.org/10.1242/dev.200528
Precise vascular patterning is crucial for normal growth and development. The ERG transcription factor drives Delta-like ligand 4 (DLL4)/Notch signalling and is thought to act as a pivotal regulator of endothelial cell (EC) dynamics and developmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8d1df014fcaf9eb06716278dbabc54
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85134426448
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85134426448
Autor:
Lars Muhl, Viktoria Kalna, Christine Tait-Burkard, Christer Betsholtz, Urban Lendahl, Samantha J. Griffiths, Liqun He, Maarja Andaloussi-Mäe, Jürgen Haas, Nicky M. Craig, Michela Noseda, Andrew H. Baker, Graeme M. Birdsey, Anna M. Randi, Alik Huseynov, Ian R McCracken, Claire Peghaire, Sarah Fletcher, Alison Daniels, Gaye Saginc
Publikováno v:
Mccracken, I R, Saginc, G, He, L, Huseynov, A, Daniels, A, Fletcher, S, Peghaire, C, Kalna, V, Andaloussi-mäe, M, Muhl, L, Craig, N M, Griffiths, S J, Haas, J G, Tait-burkard, C, Lendahl, U, Birdsey, G M, Betsholtz, C, Noseda, M, Baker, A H & Randi, A M 2021, ' Lack of Evidence of ACE2 Expression and Replicative Infection by SARSCoV-2 in Human Endothelial Cells ', Circulation . https://doi.org/10.1161/CIRCULATIONAHA.120.052824
McCracken, I, Saginc, G, He, L, Huseynov, A, Daniels, A, Fletcher, S, Peghaire, C, Kalna, V, Andaloussi-mäe, M, Muhl, L, Craig, N, Griffiths, S, Haas, J G, Tait-Burkard, C, Lendahl, U, Birdsey, G M, Betsholtz, C, Noseda, M, Baker, A H & Randi, AM 2021, ' Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells ', Circulation, vol. 143, no. 8, pp. 865–868 . https://doi.org/10.1101/2020.12.02.391664, https://doi.org/10.1161/CIRCULATIONAHA.120.052824
McCracken, I, Saginc, G, He, L, Huseynov, A, Daniels, A, Fletcher, S, Peghaire, C, Kalna, V, Andaloussi-mäe, M, Muhl, L, Craig, N, Griffiths, S, Haas, J G, Tait-Burkard, C, Lendahl, U, Birdsey, G M, Betsholtz, C, Noseda, M, Baker, A H & Randi, AM 2021, ' Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells ', Circulation, vol. 143, no. 8, pp. 865–868 . https://doi.org/10.1101/2020.12.02.391664, https://doi.org/10.1161/CIRCULATIONAHA.120.052824
A striking feature of severe COVID-19 is thrombosis in large as well as small vessels of multiple organs. This has led to the assumption that SARS-CoV-2 virus directly infects and damages the vascular endothelium. However, endothelial expression of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24aa94feee0c5342e43995e3943c7a0e
https://hdl.handle.net/20.500.11820/3bc7226a-64ab-47ee-a209-60b325542bf6
https://hdl.handle.net/20.500.11820/3bc7226a-64ab-47ee-a209-60b325542bf6
Autor:
Sarah Fletcher, Michela Noseda, Gaye Saginc, Christine Tait-Burkard, Claire Peghaire, Maarja Andaloussi-Mäe, Ian R McCracken, Alik Huseynov, Graeme M. Birdsey, Urban Lendahl, Alison Daniels, Andy Baker, Liqun He, Samantha J. Griffiths, Jürgen Haas, Nicky M. Craig, Anna M. Randi, Christer Betsholtz, Viktoria Kalna, Lars Muhl
Publikováno v:
Circulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dae7d3e586f8b353705554872fe67e
Autor:
Patricia F. Lalor, Anna M. Randi, Neil Dufton, Abhishek Chauhan, Gwilym J. Webb, Justin C. Mason, Youwen Yang, Viktoria Kalna, Claire Peghaire, David H. Adams, Claudio Raimondi, Lourdes Osuna-Almagro, Graeme M. Birdsey
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
The role of the endothelium in protecting from chronic liver disease and TGFβ-mediated fibrosis remains unclear. Here we describe how the endothelial transcription factor ETS-related gene (ERG) promotes liver homoeostasis by controlling canonical TG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5ecf529b794e568c2738b7c3814677
http://europepmc.org/articles/PMC7058024
http://europepmc.org/articles/PMC7058024