Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Graeme Laver"'
Autor:
Gui-Rong Bai, Noriko Kishida, Hiroshi Kida, Norikazu Isoda, Ayato Takada, Mai Shiromoto, Yoshihiro Sakoda, Graeme Laver
Publikováno v:
Virus Genes. 37:16-21
To investigate the prevalence of influenza viruses in feral water birds in the Southern Hemisphere, fecal samples of terns were collected on Heron Island, Australia, in December 2004. Six H2N5 influenza viruses were isolated. This is the first report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade0af2ca1a2277c099fac9e50808464
https://doi.org/10.1007/s11262-008-0235-z
https://doi.org/10.1007/s11262-008-0235-z
Autor:
Graeme Laver
Publikováno v:
Future Virology. 1:577-586
Two antiviral drugs that are currently available for the treatment of influenza are effective against all strains of the virus, if used correctly. These are the neuraminidase inhibitors, zanamivir (Relenza®) and oseltamivir (Tamiflu®). These drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d26245d4cf2ddb0c9a4582f23e06ac0
https://doi.org/10.2217/17460794.1.5.577
https://doi.org/10.2217/17460794.1.5.577
Autor:
William Graeme Laver
Publikováno v:
Perspectives in Biology and Medicine. 47:590-596
How we discovered that sea birds on the Great Barrier Reef are riddled with influenza viruses, and how one of these led to a new drug now being used in the battle against the flu.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2db1449fe6cebb5d646198db964a3b8
https://doi.org/10.1353/pbm.2004.0066
https://doi.org/10.1353/pbm.2004.0066
Autor:
Thomas J. Sowin, Minghua Sun, April Kennedy, Steven W. Muchmore, Gary Wang, Vincent S. Stoll, Yu-Gui Y. Gu, Clarence J. Maring, Chen Zhao, Graeme Laver, Kent D. Stewart, Dale J. Kempf, Darold L. Madigan, Jonathan Greer, Yuanwei Chen, Vincent L. Giranda, Hing L. Sham, Warren M. Kati, Ayda Saldivar, Yibo Xu
Publikováno v:
Biochemistry. 42:718-727
Combinatorial and structure-based medicinal chemistry strategies were used together to advance a lead compound with an activity of K(i) = 58 microM via a potency enhancement of70 000-fold to an analogue with an activity of K(i) = 0.8 nM against influ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6dd1dc3801d8ac6e79e63ff7d23d563
https://doi.org/10.1021/bi0205449
https://doi.org/10.1021/bi0205449
Autor:
W. Graeme Laver, Dale J. Kempf, Stephen Hanessian, Debra Montgomery, Jianchio Wang, Kent D. Steward, Vincent S. Stoll, Clarence J. Maring, Warren M. Kati, Charles W. Hutchins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3425-3429
Structure-based design has led to the synthesis of a novel analogue of GS-4071, an influenza neuraminidase inhibitor, in which the basic amino group has been replaced by a hydrophobic vinyl group. An X-ray co-crystal structure of the new inhibitor (K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97093ed1753db7aafea6f1f9bfb8047b
https://doi.org/10.1016/s0960-894x(02)00732-1
https://doi.org/10.1016/s0960-894x(02)00732-1
Autor:
Elspeth F. Garman, Graeme Laver
Publikováno v:
Microbes and Infection. 4:1309-1316
A "new" influenza virus will appear at some time in the future. This virus will arise by natural processes, which we do not fully understand, or it might be created by some bioterrorist. The world's population will have no immunity to the new virus,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abe488ed4bd2b37028259ffccecb630
https://doi.org/10.1016/s1286-4579(02)00013-8
https://doi.org/10.1016/s1286-4579(02)00013-8
Autor:
L. L. Horn, Sandya L Ananth, P.L. Kotian, Pooran Chand, Shanta Bantia, A. Dehghani, A J Elliott, Graeme Laver, Y. El-Kattan, T. L. Hutchison, Yarlagadda S. Babu, John A. Montgomery, T H Lin, Cynthia Parker
Publikováno v:
Journal of Medicinal Chemistry. 43:3482-3486
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269ed4efec34e4581b86557566d821f2
https://doi.org/10.1021/jm0002679
https://doi.org/10.1021/jm0002679
Publikováno v:
Scientific American. 280:78-87
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1f120da75e74ada90f7f212e96c3da
https://doi.org/10.1038/scientificamerican0199-78
https://doi.org/10.1038/scientificamerican0199-78
Autor:
Kirk A. Staschke, Angela J. Baxter, Richard J Loncharich, K. Gopal Murti, W. Graeme Laver, Elspeth F. Garman, Joseph M. Colacino, Nickolay Y Chirgadze
Publikováno v:
Virology. 236:66-75
A single change (E119G) in the influenza A virus N9 neuraminidase (NA) results in resistance of the enzyme to the NA inhibitor 4-Guanidino-Neu5Ac2en (4-GuDANA). This change causes a salt link between Glu119, which sits in a pocket in the bottom of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e60a21714e84b8b503814460023f24
https://doi.org/10.1006/viro.1997.8709
https://doi.org/10.1006/viro.1997.8709
Autor:
Dirk B. Mendel, Matthew A. Williams, Paul A. Escarpe, W. Graeme Laver, Raymond C. Stevens, Choung U. Kim, Willard Lew, Chun Y. Tai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1837-1842
The structure-activity relationships (SAR) for a new class of potent inhibitors (1) of influenza neuraminidase are described. Systematic modifications of substituents at the C-3, C-4, and C-5 positions of the carbocyclic ring were performed to establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58e3c4b492456bd923804858041c9b69
https://doi.org/10.1016/s0960-894x(97)00333-8
https://doi.org/10.1016/s0960-894x(97)00333-8