Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Graeme L. Shaw"'
1
The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity
Autor: Graeme L. Shaw, Terrence D. Mulhern, Anthony J. Day, Iain D. Campbell, Craig J. Morton
Publikováno v: Structure. 5(10):1313-1323
Background: SH2 domains are found in a variety of signal transduction proteins; they bind phosphotyrosine-containing sequences, allowing them to both recognize target molecules and regulate intramolecular kinase activity. Fyn is a member of the Src f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091da0d00bcaa2b53d5f8589495bbc57
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3
[Untitled]
Autor: Glenn F. King, Andrew J. Dingley, Joel P. Mackay, Brett D. Hambly, Graeme L. Shaw
Publikováno v: Journal of Biomolecular NMR. 10:1-8
We have previously shown that 1H pulsed-field-gradient(PFG) NMR spectroscopy provides a facile method for monitoring proteinself-association and can be used, albeit with some caveats, to measure theapparent molecular mass of the diffusant [Dingley et
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1810861a455e31e30b6dca40322af597
https://doi.org/10.1023/a:1018339526108
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5
The solution structure and dynamics of the DNA-binding domain of HMG-D from Drosophila melanogaster
Autor: James Keeler, Mair E. A. Churchill, M. Alexandra Searles, Graeme L. Shaw, Sarbjit S. Ner, Andrew Travers, David Nm Jones, David Neuhaus
Publikováno v: Structure. 2:609-627
Background The HMG-box is a conserved DNA-binding motif that has been identified in many high mobility group (HMG) proteins. HMG-D is a non-histone chromosomal protein from Drosophila melanogaster that is closely related to the mammalian HMG-box prot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed6b44fce52b0ccc0ba06796d0f55bf
https://doi.org/10.1016/s0969-2126(00)00063-0
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6
Nuclear magnetic resonance relaxation studies of poly(hydroxybutyrate) in whole cells and in artificial granules
Autor: James Keeler, Jeremy K. M. Sanders, Daniel M. Horowitz, Graeme L. Shaw, Melissa K. Melby
Publikováno v: International Journal of Biological Macromolecules. 16:59-63
The physical state of poly(hydroxybutyrate) (PHB) in whole cells and in the form of artificial biomimetic granules has been probed using 13C nuclear magnetic resonance (NMR) spectroscopy. Studies on varying concentrations of whole cells of Alcaligene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf121984f70b7c09f9148cce3e5bce02
https://doi.org/10.1016/0141-8130(94)90015-9
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7
NMR studies of a viral protein that mimics the regulators of complement activation
Autor: Jeremy R. Bright, András Perczel, Alan P. Wiles, Graeme L. Shaw, Paul N. Barlow, Iain D. Campbell
Publikováno v: Journal of molecular biology. 272(2)
Vaccinia virus complement control protein (VCP) is a 243-residue protein that is similar in sequence to the regulators of complement activation; its role is to defend the virus against attack by the host complement system. A fragment of this protein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1962f0085b50da53ea9d1dfdd539c72
https://pubmed.ncbi.nlm.nih.gov/9299352
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8
Backbone dynamics of the c-Jun leucine zipper: 15N NMR relaxation studies
Autor: Glenn F. King, Graeme L. Shaw, Joel P. Mackay
Publikováno v: Biochemistry. 35(15)
The backbone dynamics of the coiled-coil leucine zipper domain of c-Jun have been studied using proton-detected two-dimensional 1H-15N NMR spectroscopy. Longitudinal (T1) and transverse (T2) 15N relaxation times, together with {1H}15N NOEs, were meas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a178312d68ae0c06f572bdcfebcc65a
https://pubmed.ncbi.nlm.nih.gov/8664278
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9
Backbone dynamics of chymotrypsin inhibitor 2: effect of breaking the active site bond and its implications for the mechanism of inhibition of serine proteases
Autor: Alan R. Fersht, Ben Davis, James Keeler, Graeme L. Shaw
Publikováno v: Biochemistry. 34(7)
The backbone dynamics of uniformly 15N-labeled chymotrypsin inhibitor 2 (CI2) and of the complex formed by the association of two fragments consisting of residues 20-59 and 60-83 have been studied. A data set consisting of 15N longitudinal (T1) and t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0909549ec708f26f88ec17e2fdc3c61a
https://pubmed.ncbi.nlm.nih.gov/7857934
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10
Minimisation of sensitivity losses due to the use of gradient pulses in triple-resonance NMR of proteins
Autor: Ernest D. Laue, Graeme L. Shaw, Jonathan Stonehouse, Robin T. Clowes, James Keeler
Publikováno v: Journal of biomolecular NMR. 5(3)
The use of pulsed field gradients in multiple-pulse NMR experiments has many advantages, including the possibility of obtaining excellent water suppression without the need for selective presaturation. In such gradient experiments the water magnetiza
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e4d3cf1f5a07dcad8b8f2c410d0f63
https://pubmed.ncbi.nlm.nih.gov/22911500
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