Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Graeme L, Conn"'
Autor:
Janani Parameswaran, Nancy Zhang, Elke Braems, Kedamawit Tilahun, Devesh C Pant, Keena Yin, Seneshaw Asress, Kara Heeren, Anwesha Banerjee, Emma Davis, Samantha L Schwartz, Graeme L Conn, Gary J Bassell, Ludo Van Den Bosch, Jie Jiang
Publikováno v:
eLife, Vol 12 (2023)
GGGGCC (G4C2) hexanucleotide repeat expansion in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat is bidirectionally transcribed and confers gain of toxicity. Howev
Externí odkaz:
https://doaj.org/article/b5c4b7e784d04f559aa8ececa782ffe9
Autor:
Zane T. Laughlin, Graeme L. Conn
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The tuberactinomycins are a family of cyclic peptide ribosome-targeting antibiotics with a long history of use as essential second-line treatments for drug-resistant tuberculosis. Beginning with the identification of viomycin in the early 1950s, this
Externí odkaz:
https://doaj.org/article/de778e41ab674e82acdd2375e7d82cac
Publikováno v:
RSC Medicinal Chemistry. 14:624-643
The rise of multidrug-resistant bacterial infections is a cause of global concern.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::754fc0545b296faba7bc67c07d5c31c6
https://doi.org/10.1039/d2md00459c
https://doi.org/10.1039/d2md00459c
Autor:
Brenda M Calderon, Shamika Danzy, Gabrielle K Delima, Nathan T Jacobs, Ketaki Ganti, Megan R Hockman, Graeme L Conn, Anice C Lowen, John Steel
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007892 (2019)
The M segment of the 2009 pandemic influenza A virus (IAV) has been implicated in its emergence into human populations. To elucidate the genetic contributions of the M segment to host adaptation, and the underlying mechanisms, we examined a panel of
Externí odkaz:
https://doaj.org/article/8d1b51a008484550be7fee121c465810
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
Externí odkaz:
https://doaj.org/article/56700319373c4de4b9530d19d8b7a57d
Autor:
Janani Parameswaran, Nancy Zhang, Elke Braems, Kedamawit Tilahun, Devesh C Pant, Keena Yin, Seneshaw Asress, Kara Heeren, Anwesha Banerjee, Emma Davis, Samantha L Schwartz, Graeme L Conn, Gary J Bassell, Ludo Van Den Bosch, Jie Jiang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::711038c3720bbc1e8b5b669bbcb076db
https://doi.org/10.7554/elife.85902.sa2
https://doi.org/10.7554/elife.85902.sa2
The Resistance-Nodulation-Division (RND) efflux pump superfamily is pervasive among Gram-negative pathogens and contributes extensively to clinical antibiotic resistance. The opportunistic pathogenPseudomonas aeruginosacontains 12 RND-type efflux sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a3d441cb7f55b63210857a69ac6b025
https://doi.org/10.1101/2023.03.24.533986
https://doi.org/10.1101/2023.03.24.533986
Autor:
Pooja Srinivas, Meisam Nosrati, Natalia Zelinskaya, Debayan Dey, Lindsay R. Comstock, Christine M. Dunham, Graeme L. Conn
Publikováno v:
bioRxiv
Acquired ribosomal RNA (rRNA) methylation has emerged as a significant mechanism of aminoglycoside resistance in pathogenic bacterial infections. Modification of a single nucleotide in the ribosome decoding center by the aminoglycoside-resistance 16S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36a7687d6663ee93546431136a6f16f
https://europepmc.org/articles/PMC10054953/
https://europepmc.org/articles/PMC10054953/
Autor:
Sarah E. Strassler, Isobel E. Bowles, Aiswarya Krishnamohan, Hyejeong Kim, Emily G. Kuiper, Lindsay R. Comstock, Jane E. Jackman, Graeme L. Conn
Publikováno v:
bioRxiv
The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the 9th nucleotide in the tRNA core. Trm10 is conserved throughout Eukarya and Archaea, and mutations in the human gene (TRMT10A) have been linked to neurological disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77869d49271800f1881f022c07e6fa6
https://europepmc.org/articles/PMC9915607/
https://europepmc.org/articles/PMC9915607/
Publikováno v:
Journal of Chemical Information and Modeling. 61:4442-4454
The emergence of new viral infections and drug resistant bacteria urgently necessitates expedient therapeutic development. Repurposing and redesign of existing drugs against different targets is one potential way in which to accelerate this process.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de096e76ff3d8f511321ff905ab6fa6f
https://doi.org/10.1021/acs.jcim.1c00578
https://doi.org/10.1021/acs.jcim.1c00578