Genome-Wide Gene Expression Analysis Shows AKAP13-Mediated PKD1 Signaling Regulates the Transcriptional Response to Cardiac Hypertrophy.

Autor: Keven R Johnson, Jessie Nicodemus-Johnson, Mathew J Spindler, Graeme K Carnegie

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132474 (2015)

In the heart, scaffolding proteins such as A-Kinase Anchoring Proteins (AKAPs) play a crucial role in normal cellular function by serving as a signaling hub for multiple protein kinases including protein kinase D1 (PKD1). Under cardiac hypertrophic c

Externí odkaz: https://doaj.org/article/9fe7c9ea9ab04da79d951301ae5e2d78

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

Autor: Katy A Wong, Jessica Wilson, Angela Russo, Li Wang, Mustafa Nazir Okur, Xuerong Wang, Negin P Martin, Erica Scappini, Graeme K Carnegie, John P O'Bryan

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e36023 (2012)

Members of the intersectin (ITSN) family of scaffold proteins consist of multiple modular domains, each with distinct ligand preferences. Although ITSNs were initially implicated in the regulation of endocytosis, subsequent studies have revealed a mo

Externí odkaz: https://doaj.org/article/83cd7a04befd4801a3e800de61643c21

Aurora Kinases

Autor: Esther E. Biswas-Fiss, Stephanie Affet, Malissa Ha, Takaya Satoh, Joe B. Blumer, Stephen M. Lanier, Ana Kasirer-Friede, Benjamin J. Gosney, Venkateswarlu Kanamarlapudi, Ferenc András Antoni, Carmen W. Dessauer, Rachna Sadana, Christiane Kirchhoff, Ben Davies, Nazanine Modjtahedi, Guido Kroemer, Graeme K. Carnegie, John D. Scott, Bryan A. Anthony, Gregg A. Hadley, Hatice Zeynep Kirli, Martina Tesikova, Fahri Saatcioglu, Søren Paludan Sheikh, Grégory Tufo, Lorenzo Galluzzi, Catherine Brenner, Andrew A. Peden, Shinji Matsuda, Michisuke Yuzaki, Luis Martinez-Lostao, Alberto Anel, Javier Naval, Jens Rauch, Walter Kolch, Siân-Eleri Owens, Joel Moss, Martha Vaughan, Moran Rawet-Slobodkin, Deike Hesse, Alexander Jaschke, Annette Schürmann, Katherine Figella, Brad Allen Bryan, Mingyao Liu, Aiysha Thompson, Tsonwin Hai, Johnna Dominick, Kun Huang, David Reboutier, Claude Prigent

Publikováno v: Encyclopedia of Signaling Molecules
Encyclopedia of Signaling Molecules, pp.177-183, 2012, ⟨10.1007/978-1-4419-0461-4_81⟩
Encyclopedia of Signaling Molecules ISBN: 9781461464389

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20badff01ff3a1671da54657afd5732
https://doi.org/10.1007/978-3-319-67199-4_81

Endothelial Barrier Protection by Local Anesthetics

Autor: Graeme K. Carnegie, E. Gina Votta-Velis, Tobias Piegeler, Mao Mao, Alain Borgeat, David E. Schwartz, Beatrice Beck-Schimmer, Richard D. Minshall, Marcelo G. Bonini, Farnaz R. Bakhshi

Publikováno v: Anesthesiology. 120:1414-1428

Background: Pulmonary endothelial barrier dysfunction mediated in part by Src-kinase activation plays a crucial role in acute inflammatory disease. Proinflammatory cytokines, such as tumor necrosis factor-α (TNFα), activate Src via phosphatidylinos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e823cd3fa7e35fd1561de28d8b3a24d7
https://doi.org/10.1097/aln.0000000000000174

AKAP-Lbc Mobilizes a Cardiac Hypertrophy Signaling Pathway

Autor: Fang Zhang, F. Donelson Smith, Alexandra C. Newton, Dario Diviani, Lorene K. Langeberg, John D. Scott, Joseph Soughayer, Michael R. Bristow, Maya T. Kunkel, Graeme K. Carnegie, Benjamin S. Pedroja

Publikováno v: Molecular Cell, vol. 32, no. 2, pp. 169-179

Elevated catecholamines in the heart evoke transcriptional activation of the Myocyte Enhancer Factor (MEF) pathway to induce a cellular response known as pathological myocardial hypertrophy. We have discovered that the A-Kinase Anchoring Protein (AKA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784529f321a20f89764ff93eefc37bb5